RADICALS 2009

The Development of a Novel Tin-Free Radical Methodology and its Application to the Asymmetric Total Synthesis of (+)-Ineleganolide

Coordinatore	ECOLE POLYTECHNIQUE    more  Organization address address: ROUTE DE SACLAY city: PALAISEAU postcode: 91128 contact info Titolo: Ms. Nome: Aurélie Cognome: Eray Email: send email Telefono: +33 1 69 33 32 54
Nazionalità Coordinatore	France [FR]
Totale costo	166˙645 €
EC contributo	166˙645 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IIF
Funding Scheme	MC-IIF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE  Organization address address: ROUTE DE SACLAY city: PALAISEAU postcode: 91128 contact info Titolo: Ms. Nome: Aurélie Cognome: Eray Email: send email Telefono: +33 1 69 33 32 54	FR (PALAISEAU)	coordinator	166˙645.60

Mappa

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 Obiettivo del progetto (Objective)

'Preliminary work in the Zard's group has shown that cyclopropylacyl radicals can be generated from the corresponding xanthates. These unique species do not easily undergo decarbonylation or ring opening processes. These features can be exploited because the products, cyclopropyl ketones, have been found to be exceptional substrates in organic synthesis. Additionally, control of the decarbonylation and/or ring-opening processes can be combined with the powerful nature of the xanthate transfer technology in a synergistic way to provide complex skeletal diversity. The first part of the project will not only exploit the observed reactivity pattern for cyclopropylacyl radicals but will expand significantly their chemical reactivity and scope. The second part of the project will apply these findings to the asymmetric total synthesis of the natural product ()-Ineleganolide.'

Introduzione (Teaser)

Researchers have identified a new precursor molecule for the simple production of cyclopropylketones, important intermediate compounds in the synthesis of pharmaceuticals.