THC-ASKID

T Helper cell lineages and their Cytokines in Autoimmune SKin Disease

Coordinatore	UNIVERSITAETSKLINIKUM HEIDELBERG    more  Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 contact info Nome: Thorsten Cognome: Brietz Email: send email Telefono: +49 6221 56 7086
Nazionalità Coordinatore	Germany [DE]
Totale costo	75˙000 €
EC contributo	75˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-06-01   -   2014-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAETSKLINIKUM HEIDELBERG  Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 contact info Nome: Thorsten Cognome: Brietz Email: send email Telefono: +49 6221 56 7086	DE (HEIDELBERG)	coordinator	75˙000.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated. After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles. While in atopic dermatitis for example skin infiltrating T cells mainly show a Th2-polarization, in psoriasis, which is mediated by autoreactive T cells of the Th1-phenotype, recent evidence indicates an important pathogenic role for Th17 cells. However, it is not fully understood why a particular disease setting leads to a certain predominant T helper cell polarization and the consecutive skin phenotype. Given the high prevalence of psoriasis and atopic dermatitis in western countries, it is of great interest to elucidate the mechanisms of disease development and how they can be manipulated therapeutically. Previously I have shown that Scurfy mice harbor autoreactive T cells recognizing antigens in the skin and developed the “Scurfy Transfer Model”. In this model autoreactive CD4 T cells from Scurfy mice are transferred into RAG-/- recipients and induce skin disease within 4 weeks. Thus I am now able to transfer either naive or different types of pre-differentiated CD4 T helper cells and to analyse the resulting skin phenotype. The following questions will be addressed: Which T helper cell polarization will spontaneously occur after transfer of naïve auto-reactive T cells into RAG-/- recipients? Which factors lead to that particular development? Which skin phenotype is induced after transfer of pre-differentiated Th1, Th2, Th9 and Th17 T helper cells? Are there shared phenotypic features of the induced skin phenotype and human autoimmune skin diseases? How can T helper cell polarization be manipulated in vivo? In conclusion, the general objective of this research proposal is to evaluate the distinct skin pathologies induced by different T helper cell lineages derived from skin-autoreactive CD4 T cells in the “Scurfy Transfer Model”.'