FUSIMO
Patient specific modelling and simulation of focused ultrasound in moving organs
| Coordinatore | FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Organization address
address: Hansastrasse 27C contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 4˙684˙688 € |
| EC contributo | 3˙471˙679 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2009-6 |
| Funding Scheme | CP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-01-01 - 2014-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Organization address
address: Hansastrasse 27C contact info |
DE (MUENCHEN) | coordinator | 0.00 |
| 2 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | participant | 0.00 |
| 3 |
Fundatia Medis
Organization address
address: STRADA NICOLAE BALCESCU 53 contact info |
RO (CAMPINA) | participant | 0.00 |
| 4 |
GE MEDICAL SYSTEMS ISRAEL LTD
Organization address
address: ETGAR 4 contact info |
IL (TIRAT CARMEL) | participant | 0.00 |
| 5 |
IBSmm Engineering spol. s r. o.
Organization address
address: Hybesova 42 contact info |
CZ (Brno) | participant | 0.00 |
| 6 |
INSIGHTEC LTD
Organization address
address: Nachum Heth Street 5 contact info |
IL (TIRAT CARMEL) | participant | 0.00 |
| 7 |
Medical Imaging Research Institute
Organization address
address: Vangerowstr. 18 contact info |
DE (Heidelberg) | participant | 0.00 |
| 8 |
STIFTELSEN SINTEF
Organization address
address: STRINDVEIEN 4 contact info |
NO (TRONDHEIM) | participant | 0.00 |
| 9 |
TECHNISCHE UNIVERSITEIT DELFT
Organization address
address: Stevinweg 1 contact info |
NL (DELFT) | participant | 0.00 |
| 10 |
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Organization address
address: Piazzale Aldo Moro 5 contact info |
IT (ROMA) | participant | 0.00 |
| 11 |
UNIVERSITY OF DUNDEE
Organization address
address: Nethergate contact info |
UK (DUNDEE) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. Applications in the treatment of fibroadenoma of uterus has become commercial and passed FDA clearance in 2004 and sonication of bone metastasis has obtained a CE mark. Other tumours are under preclinical (prostate, kidney) and clinical (breast, brain and liver) evaluation. However, treating tumours with focused ultrasound is still challenging in terms of reliable therapy planning, monitoring and outcome prediction especially in moving organs with a complex blood supply. It is important to understand that the processes involved in FUS therapy are multi-level ranging from organ morphology, perfusion and motion, down to microscopic and cellular level. The relation within and between these levels is not well understood.nFUSIMO will develop, implement and validate a multi-level model for moving abdominal organs for use with FUS and Magnetic resonance-guided focused ultrasound surgery. The overall model will consist of several sub-models, which interact and describe aspects in a hierarchical manner. The integrated model will consist of;n- Abdominal organ model to simulate motion and the influence on ultrasound applicationn- Target organ/tumour model to capture organ/tumour physiology, and organ/tumour reaction to therapyn- Microscopic tissue model to simulate direct heat ablation, model energy distribution, tissue heating and coolingn- Model to evaluate first steps to simulate drug delivery, microbubble distribution and dynamicsnThe FUSIMO developments in the field of hardware and software will be combined into an integrated system, which will allow both abdominal FUS application to moving organs, and also other treatment modalities such as radio frequency, laser or cryotherapy or other types of interventions based on particles or fields in radiation therapy.