GENEFOREST

Integrating Pattern and Process to Reconstruct the Phylogeny of Genomes

Coordinatore	UNIVERSITE LYON 1 CLAUDE BERNARD    more  Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 contact info Titolo: Dr. Nome: Vincent Cognome: Daubin Email: send email Telefono: +33 4 26 23 44 74 Fax: +33 4 72 43 13 88
Nazionalità Coordinatore	France [FR]
Totale costo	173˙662 €
EC contributo	173˙662 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-01   -   2013-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE LYON 1 CLAUDE BERNARD  Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 contact info Titolo: Dr. Nome: Vincent Cognome: Daubin Email: send email Telefono: +33 4 26 23 44 74 Fax: +33 4 72 43 13 88	FR (VILLEURBANNE CEDEX)	coordinator	173˙662.40

Mappa

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 Obiettivo del progetto (Objective)

'Darwin in the Origin of Species laid the foundations of modern evolutionary biology on two central ideas: (i) all species are related to each other through a history of common descent, and (ii) the delicate match between a species and its environment is explained by natural selection. These two ideas embody the duality of pattern and process that is a fundamental feature of the evolution of life on earth: the unique historic pattern of descent and the interplay of population genetic and genomic processes that have generated it.

In the proposed research I plan to undertake the reconstruction of the historic pattern of genome evolution across a broad phylogenetic range encompassing the three domains of life. I aim to reconstruct the prevailing trend of genomic descent (the tree of genomes) together with inference of the genomic process that relate it to the histories of its constituent parts (the forest of gene trees). Explicitly considering these processes, i.e. the history of gene transfers, duplications and losses will permit the use of complete genomes, instead of a handful of genes. The proposed large scale reconstruction will also enable the development of a valuable database of gene transfer, duplication and loss events that could potentially benefit a wide range of biological research. I will use this database to investigate the role of horizontal gene transfer (HGT) in genomic innovation, and ask questions about the biochemical, regulatory and ecological opportunities and constraints that govern the process of gene acquisition and loss that gave rise to the observed phylogenetic pattern of HGT.

During the course of the fellowships I will be able to use my experience in developing quantitative evolutionary models and preforming Monte Carlo simulations in an entirely new setting. I expect to obtain extensive experience at both the theoretical level, in evolutionary genomics and phylogenetic inference, as well as at the methodological level, in handling la'

Introduzione (Teaser)

EU-funded scientists developed large-scale mathematical models of evolutionary biology that promise to shed light on the history of life and the processes of genome evolution.