SYT ACTIVITY

Modulation of synaptic plasticity and circuit function by regulation of neurotrophin exocytosis

Coordinatore	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙484˙000 €
EC contributo	1˙484˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2016-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS  Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 contact info Titolo: Dr. Nome: Camin Cognome: Dean Email: send email Telefono: +49 551 39 13903	DE (GOETTINGEN)	hostInstitution	1˙484˙000.00
2	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS  Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 contact info Titolo: Ms. Nome: Christiane Cognome: Hennecke Email: send email Telefono: 49551398770 Fax: 495514000000	DE (GOETTINGEN)	hostInstitution	1˙484˙000.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'A fundamental question in neuroscience is how individual synapses and neurons act in concert to create functional circuits. While the basic mechanisms of synaptic transmission between neurons are well understood, much less is known about how individual synapses, neurons, and circuits dynamically adjust their transmission properties in response to perturbations in network activity. During the past few years I have begun a new line of research: the regulation of neurotrophin vesicle release and its effect on synaptic plasticity and learning and memory. These discoveries come at a crucial time, given mounting evidence that BDNF and other neurotrophins and neuropeptides affect synaptic plasticity, while at the same virtually nothing is known about the regulation of their release and the mechanisms by which they affect synapse and circuit function. To continue this research I would like to form my own research group. I am interested in the mechanisms by which individual synapses and neurons respond to changes in activity to modify circuit function and ultimately behavior. I investigate the mechanisms of activity-dependent plasticity at three different levels: single synapses, single cells and neuronal networks, using a combination of manipulation of protein expression and function, biochemistry, electrophysiology and live imaging approaches in neuron cultures and brain slices. My overall goal is to understand how neurons communicate changes in activity to affect circuit function.'