MESENDOT

Regulation of mesenchymal stem cells by vasculature and enhancement of their regenerative potential for the treatment of acute myocardial infarction

Coordinatore	SERVICIO MADRILENO DE SALUD    more  Organization address address: PLAZA CARLOS TRIAS BERTRAN 7 city: MADRID postcode: 28020 contact info Titolo: Mr. Nome: Luis J. Cognome: Fernandez Vera Email: send email Telefono: 34915868698 Fax: 34914008156
Nazionalità Coordinatore	Spain [ES]
Totale costo	230˙980 €
EC contributo	230˙980 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SERVICIO MADRILENO DE SALUD  Organization address address: PLAZA CARLOS TRIAS BERTRAN 7 city: MADRID postcode: 28020 contact info Titolo: Mr. Nome: Luis J. Cognome: Fernandez Vera Email: send email Telefono: 34915868698 Fax: 34914008156	ES (MADRID)	coordinator	230˙980.00

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 Obiettivo del progetto (Objective)

'Mesenchymal stem cells (MSCs) can contribute to the regeneration of different tissues by differentiating into a wide variety of cell types, including cardiomyocytes, adipocytes and endothelial cells among others. MSCs represent a reliable source of adult stem cells in humans. A recent report suggests that MSCs concentrate around blood vessels, although the MSC natural microenvironment (niche) is not completely understood. In this project, we aim to study the biology of Bone Marrow derived stem cells (BM-MSCs) and Adipose tissue-derived mesenchymal stem cells (ASCs) in their niche and exploit this knowledge for the treatment of myocardial infarction. We will analyze the interaction of these two types of MSCs with blood vessels, identify the molecules involved and compare which one is more effective for cardiac regeneration. Objectives: 1) Determine the effect of blood vessel-derived cells on human and mouse MSCs; 2) Define the interactions between MSCs and blood vessel-derived cells in the human and mouse MSC niche, including the identification of the molecules mediating direct cell contact and the soluble factors mediating the paracrine effect of blood vessels; 3) Determine the role of the identified factors in the MSC niche in vitro and in vivo by using recombinant proteins and neutralizing antibodies; 4) Compare the potential of BM-MSCs versus ASCs for myocardial regeneration and repair, and investigate the capacity of the identified factor s to enhance this potential. The results will contribute to the development of novel therapeutic strategies for the treatment of myocardial infarction. The project will provide specific training for the researcher in the field of human stem cells, cardiovascular research and general issues related to clinical as well as basic human research that will help the transition of her career into translational research.'