THPLAST

The molecular regulation of T helper cell subtype plasticity

 Coordinatore GENOME RESEARCH LIMITED 

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Mr.
Nome: David
Cognome: Davison
Email: send email
Telefono: +44 1223 834244

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 211˙092 €
 EC contributo 211˙092 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2010-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-08-08   -   2014-02-04

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    GENOME RESEARCH LIMITED

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Mr.
Nome: David
Cognome: Davison
Email: send email
Telefono: +44 1223 834244

UK (LONDON) coordinator 211˙092.80
2    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Ms.
Nome: Elizabeth
Cognome: Cutler
Email: send email
Telefono: +44 122 340 2357

UK (SWINDON) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cells    regulation    expression    effector    molecular    subset    cytokines    dynamics    interactions    plasticity    rna    cell    transcription    biology   

 Obiettivo del progetto (Objective)

'Naïve CD4 T cell differentiate into distinct lineages to achieve successful adaptive immune responses to diverse categories of pathogens. The development of these effector cells is controlled by cytokines, transcription factor interactions and chromatin modifications. In addition, several of the differentiated subtypes can interconvert, a property known as plasticity. However, the molecular regulation of flexibility of this subset cells is still unresolved. I propose to explore the molecular machinery of the T helper (Th) effector cells’ plasticity, specifically of Th subset 2 plasticity to Th1, as understanding of this reprogramming is a key target of autoimmune- and allergen-specific immunotherapy. I plan to study the regulation of Th2-Th1 cell plasticity both experimentally and computationally. I will identify the gene expression level dynamics as well as the epigenetic events during plasticity using RNA- and ChIP-deep sequencing. These results will be processed by computational tools to define the hierarchy and dynamics of molecular regulators, and to predict key molecular players (transcription factors, microRNAs) responsible for expression of the specific cytokines. I will also monitor specific RNA and protein expression at a single cell level, and identify specific regulatory interactions, including the nucleic acid motifs involved. This research will reveal insights into the balance between lineage commitment and plasticity, which is a key question in developmental biology, and in general will impact a wide range of areas in biology from stem cell biology to cancer.'

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