MOLECULARDOCTORS
RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer
| Coordinatore | HUMBOLDT-UNIVERSITAT ZU BERLIN
Organization address
address: UNTER DEN LINDEN 6 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 163˙242 € |
| EC contributo | 163˙242 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-04-01 - 2013-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
HUMBOLDT-UNIVERSITAT ZU BERLIN
Organization address
address: UNTER DEN LINDEN 6 contact info |
DE (BERLIN) | coordinator | 163˙242.40 |
Mappa
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Obiettivo del progetto (Objective)
'In this proposal we intend to develop a new medicinal chemistry concept base on cell-personalized delivery of tailored drugs. Relying on basic chemical tools such as proximity-induced acyl transfer reactions and catalytic turnover- we will use RNA biomarkers of cancer cells to trigger the specific expression of cytotoxic drugs. This approach, in addition to contribute to basic science in chemistry and chemical and cell biology and suggest new therapeutic strategies, might allow to overcome the most important observed complications in cancer treatment: selectivity and resistance.'
Introduzione (Teaser)
Modern sequencing technologies create data that link diseases such as cancer to personal genetic information. Can we use this genetic information in the development of new therapeutic principles?
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