INTERIMPACT

Impact of identified interneurons on cellular network mechanisms in the human and rodent neocortex

Coordinatore	more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Non specificata
Totale costo	2˙391˙694 €
EC contributo	2˙391˙694 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100317
Funding Scheme	ERC-A
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-06-01   -   2016-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SZEGEDI TUDOMANYEGYETEM  Organization address address: DUGONICS TER 13 city: SZEGED postcode: 6720 contact info Titolo: Ms. Nome: Eszter Cognome: Kocsis Email: send email Telefono: 3662544896 Fax: 3662544897	HU (SZEGED)	hostInstitution	2˙391˙694.80
2	SZEGEDI TUDOMANYEGYETEM  Organization address address: DUGONICS TER 13 city: SZEGED postcode: 6720 contact info Titolo: Prof. Nome: Gábor Cognome: Tamás Email: send email Telefono: 3662544851 Fax: 3662544291	HU (SZEGED)	hostInstitution	2˙391˙694.80

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 Obiettivo del progetto (Objective)

'This application addresses mechanisms linking the activity of single neurons with network events by defining the function of identified cell types in the cerebral cortex. The key hypotheses emerged from our experiments and propose that neurogliaform cells and axo-axonic cells achieve their function in the cortex through extreme forms of unspecificity and specificity, respectively. The project capitalizes on our discovery that neurogliaform cells reach GABAA and GABAB receptors on target cells through unitary volume transmission going beyond the classical theory which states that single cortical neurons act in or around synaptic junctions. We propose that the spatial unspecificity of neurotransmitter action leads to unprecedented functional capabilities for a single neuron simultaneously acting on neuronal, glial and vascular components of the surrounding area allowing neurogliaform cells to synchronize metabolic demand and supply in microcircuits. In contrast, axo-axonic cells represent extreme spatial specificity in the brain: terminals of axo-axonic cells exclusively target the axon initial segment of pyramidal neurons. Axo-axonic cells were considered as the most potent inhibitory neurons of the cortex. However, our experiments suggested that axo-axonic cells can be the most powerful excitatory neurons known to date by triggering complex network events. Our unprecedented recordings in the human cortex show that axo-axonic cells are crucial in activating functional assemblies which were implicated in higher order cognitive representations. We aim to define interactions between active cortical networks and axo-axonic cell triggered assemblies with an emphasis on mechanisms modulated by neurogliaform cells and commonly prescribed drugs.'