PRONEURODEG

Regulation of cellular proliferation in chronic neurodegenerative disease: Microglial proliferation and neurogenesis in prion disease

Coordinatore	UNIVERSITY OF SOUTHAMPTON    more  Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ contact info Titolo: Mr. Nome: Simon Cognome: Mason Email: send email Telefono: +44 23 8059 8160 Fax: +44 23 8059 2195
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	200˙549 €
EC contributo	200˙549 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-09-01   -   2013-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF SOUTHAMPTON  Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ contact info Titolo: Mr. Nome: Simon Cognome: Mason Email: send email Telefono: +44 23 8059 8160 Fax: +44 23 8059 2195	UK (SOUTHAMPTON)	coordinator	200˙549.60

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 Obiettivo del progetto (Objective)

'An important aspect of chronic neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s or prion disease, is the generation of an innate inflammatory reaction within the central nervous system. Microglial cells play a leading role in the development and maintenance of this inflammatory reaction, showing enhanced proliferation and morphological activation. Moreover, during neurodegeneration and inflammation, the mechanisms that control neural stem cell biology are altered and may also affect disease progression, causing impaired neural stem cell renewal, migration and differentiation. Since these proliferative responses are both involved in neurodegeneration they may share common or perhaps antagonistic regulatory pathways. In this project, using a tractable laboratory model of neurodegeneration (murine prion disease), we will study the time-course and molecular regulation of microglial and neural stem cell proliferative responses. Moreover, we will analyze the role of the inflammatory milieu in the regulation of the proliferative responses, in order to throw light on the progression of chronic neurodegeneration. These objectives will be addressed using a multidisciplinary technical approach, combining the use of transgenic animal models with cell culture systems, analyzed by cellular and molecular biology techniques. Furthermore, we will cross-validate our studies with the analysis of the microglial and neural stem cell proliferative responses in post-mortem brain samples from Alzheimer’s disease patients. This powerful combined approach would permit us to obtain results that will contribute to the understanding of mechanisms that drive progression of chronic neurodegeneration.'

Introduzione (Teaser)

Prion diseases are a group of progressive neurodegenerative disorders that were initially reported in the 1980's. Thirty years later, scientists are beginning to understand the events that take place during neurodegeneration.