I-MIRNOME

Lymphocyte microRNAs in health and disease: Understanding lymphocyte functions through the identification of microRNA target genes and exploiting serum microRNA signatures to monitor immune responses

Coordinatore	FONDAZIONE ISTITUTO NAZIONALE DI GENETICA MOLECOLARE INGM    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Italy [IT]
Totale costo	2˙496˙000 €
EC contributo	2˙496˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100317
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-06-01   -   2016-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE ISTITUTO NAZIONALE DI GENETICA MOLECOLARE INGM  Organization address address: Via Francesco Sforza 35 city: MILANO postcode: 20122 contact info Titolo: Mr. Nome: Stefano Cognome: Apollonio Email: send email Telefono: +39 2 00660209 Fax: +39 2 00660216	IT (MILANO)	hostInstitution	2˙496˙000.00
2	FONDAZIONE ISTITUTO NAZIONALE DI GENETICA MOLECOLARE INGM  Organization address address: Via Francesco Sforza 35 city: MILANO postcode: 20122 contact info Titolo: Prof. Nome: Sergio Cognome: Abrignani Email: send email Telefono: +39 2 00660211 Fax: +39 2 00660216	IT (MILANO)	hostInstitution	2˙496˙000.00

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 Obiettivo del progetto (Objective)

'Background: CD4 T lymphocyte subsets orchestrate immune responses in health and disease. Little is known on control of T cell differentiation exerted by microRNA that affect mRNA translation. The identification of microRNA and their targets that regulate differentiation of T cell subsets may provide new therapeutic targets for immune-mediated diseases. Since microRNA are released in exosomes and circulate in blood, activities of tissue-derived lymphocytes could be assessed by microRNA signatures in the serum. We have defined microRNAs present in resting lymphocyte subsets from peripheral blood and measured lymphocyte-derived microRNAs in the serum. We have also solved important challenges for the identification of microRNA targets, the definition of signatures of activated T cells and their monitoring in the serum, which form the key topics of this application. Advancing State-of-the-Art and objectives: We will identify microRNA of CD4 T cell subsets purified from inflamed organs and investigate microRNA target network that regulates T cell differentiation. We will exploit this knowledge to profile signatures of in vivo activated T cells and to map genes that could improve understanding of T cell commitment. We will also develop quantitative assays to monitor microRNA signatures in the serum and provide functional evidence of key genes targeted by microRNA which could be targets of immunomodulatory drugs. Significance: This application addresses important challenges at the frontiers of immunology and could lead to significant advances in immunotherapies and diagnostic tools for patients with immune mediated diseases. New ways of identifying microRNA targets and techniques to quantify microRNA signatures in the serum, could be widely applicable in biomedical research.'