BIO-MAPS

Bio-mimetic Multi-functional Active Porous Structures

Coordinatore	Sabanci University    more  Organization address address: Orhanli Tuzla city: ISTANBUL postcode: 34956 contact info Titolo: Mrs. Nome: Aslihan Cognome: Eran Email: send email Telefono: +90 216 483 9110 Fax: +90 216 483 9118
Nazionalità Coordinatore	Turkey [TR]
Totale costo	75˙000 €
EC contributo	75˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-09-01   -   2014-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Sabanci University  Organization address address: Orhanli Tuzla city: ISTANBUL postcode: 34956 contact info Titolo: Mrs. Nome: Aslihan Cognome: Eran Email: send email Telefono: +90 216 483 9110 Fax: +90 216 483 9118	TR (ISTANBUL)	coordinator	75˙000.00

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 Obiettivo del progetto (Objective)

'The objective of this research plan is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures with controlled material composition and distribution. The proposed work will be used to model active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements.

First, computational algorithms are proposed to optimally design multi-material with bio-active molecules spatially in porous structures. A new design methodology is proposed to relate material and bioactive distribution to 3D shape (geometry). The internal micro-architecture of porous structures is also optimized based on biological and mechanical requirements. Second, a novel bio-fabrication processed is proposed to fabricate designed multi-functional active porous structures with various biodegradable materials embedded with active bio-molecules directly from the computer models. The proposed methodologies will be applied to 3D tissue scaffolds. Cell migration into design 3D scaffold will be tested in-vitro to assess and optimize the proposed methodologies. The proposed methods will make more advanced active scaffold systems possible. These active multi-functional porous structures could be used to arrange cells in an appropriate 3D configuration and present molecular signals in a spatial and temporal fashion so that the individual cells will grow and form the desired tissue structures.

The results from this research would enable use of active implants, tissue/organ substitutes and micro-scale bio-sensors in many new applications in medicine and biomedical engineering. This project will also advance the knowledge in heterogeneous object modelling in computer-aided design, layered-based fabrication methodologies and biomaterials.'