Coordinatore | Sabanci University
Organization address
address: Orhanli Tuzla contact info |
Nazionalità Coordinatore | Turkey [TR] |
Totale costo | 75˙000 € |
EC contributo | 75˙000 € |
Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
Code Call | FP7-PEOPLE-2011-CIG |
Funding Scheme | MC-CIG |
Anno di inizio | 2011 |
Periodo (anno-mese-giorno) | 2011-09-01 - 2014-08-31 |
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1 |
Sabanci University
Organization address
address: Orhanli Tuzla contact info |
TR (ISTANBUL) | coordinator | 75˙000.00 |
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
'The objective of this research plan is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures with controlled material composition and distribution. The proposed work will be used to model active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements.
First, computational algorithms are proposed to optimally design multi-material with bio-active molecules spatially in porous structures. A new design methodology is proposed to relate material and bioactive distribution to 3D shape (geometry). The internal micro-architecture of porous structures is also optimized based on biological and mechanical requirements. Second, a novel bio-fabrication processed is proposed to fabricate designed multi-functional active porous structures with various biodegradable materials embedded with active bio-molecules directly from the computer models. The proposed methodologies will be applied to 3D tissue scaffolds. Cell migration into design 3D scaffold will be tested in-vitro to assess and optimize the proposed methodologies. The proposed methods will make more advanced active scaffold systems possible. These active multi-functional porous structures could be used to arrange cells in an appropriate 3D configuration and present molecular signals in a spatial and temporal fashion so that the individual cells will grow and form the desired tissue structures.
The results from this research would enable use of active implants, tissue/organ substitutes and micro-scale bio-sensors in many new applications in medicine and biomedical engineering. This project will also advance the knowledge in heterogeneous object modelling in computer-aided design, layered-based fabrication methodologies and biomaterials.'
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