diXa

Data Infrastructure for Chemical Safety

Coordinatore	UNIVERSITEIT MAASTRICHT    more  Organization address address: Universiteitssingel 50 city: Maastricht postcode: 6229ER contact info Titolo: Prof. Nome: Jos Cognome: Kleinjans Email: send email Telefono: 31433881845 Fax: 31433884146
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	3˙678˙746 €
EC contributo	2˙800˙000 €
Programma	FP7-INFRASTRUCTURES Specific Programme "Capacities": Research infrastructures
Code Call	FP7-INFRASTRUCTURES-2011-2
Funding Scheme	CPCSA
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2014-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT  Organization address address: Universiteitssingel 50 city: Maastricht postcode: 6229ER contact info Titolo: Prof. Nome: Jos Cognome: Kleinjans Email: send email Telefono: 31433881845 Fax: 31433884146	NL (Maastricht)	coordinator	0.00
2	EUROPEAN MOLECULAR BIOLOGY LABORATORY  Organization address address: Meyerhofstrasse city: HEIDELBERG postcode: 69117 contact info Titolo: Dr. Nome: Gabriele Cognome: Picarella Email: send email Telefono: +44 1223 492 520 Fax: +44 1223 494 470	DE (HEIDELBERG)	participant	0.00
3	GENEDATA AG  Organization address address: MARGARETHENSTRASSE city: BASEL postcode: 4053 contact info Titolo: Dr. Nome: Timo Cognome: Wittenberger Email: send email Telefono: +41 61 5118 443 Fax: +41 61 5118 585	CH (BASEL)	participant	0.00
4	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: Exhibition Road, South Kensington Campus city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Palalic Email: send email Telefono: +44 207 59 43161 Fax: +44 207 594 3868	UK (LONDON)	participant	0.00
5	JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION  Organization address address: Rue de la Loi city: BRUSSELS postcode: 1049 contact info Titolo: Mr. Nome: Eric Cognome: Cremer Email: send email Telefono: +39 0332789717 Fax: +39 0332786210	BE (BRUSSELS)	participant	0.00
6	KLINIKUM DER UNIVERSITAET ZU KOELN  Organization address address: Kerpener Strasse city: KOELN postcode: 50937 contact info Nome: Jutta Cognome: Landvogt Email: send email Telefono: +49 221 478 5204 Fax: +49 221 478 87752	DE (KOELN)	participant	0.00
7	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Anke Cognome: Badrow Email: send email Telefono: +49 30 84131422	DE (MUENCHEN)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially better acceptable. Consumer's and patient's health will benefit and competitiveness of EU's chemical manufacturing industry will be increased. For developing such assays, FP6/FP7 Research Programmes are exploiting the revenues of data-dense genomics technologies. However, till date, there is no infrastructure foreseen which aims at capturing all data produced by toxicogenomics (TGX) projects, in a standardized, harmonized and sustainable manner. Data may thus evaporate. The lack of such an infrastructure also prevents innovative breakthroughs from meta-analyses of joint databases and systems modeling.nDriven by these needs of the TGX research community, diXa will focus on networking activities, for building a web-based, openly accessible and sustainable e-infrastructure for capturing TGX data, and for linking this to available data bases holding chemico/physico/toxicological information, and to data bases on molecular medicine, thus crossing traditional borders between scientific disciplines and reaching out to other research communities. To advance data sharing, diXa will ensure clear communication channels with and deliver commonly agreed core service support to the TGX research community, by providing SOPs for seamless data sharing, and by offering quality assessments and newly developed tools and techniques for data management, all supported by hands-on training. Through its joint research initiative, by using data available from its data infrastructure, diXa will demonstrate the feasibility of its approach by performing cross-platform integrative statistical analyses, and cross-study meta-analyses, to create a systems model for predicting chemical-induced liver injury.