Explore the words cloud of the EuroMix project. It provides you a very rough idea of what is the project "EuroMix" about.
The following table provides information about the project.
Coordinator |
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | https://www.euromixproject.eu |
Total cost | 8˙821˙295 € |
EC max contribution | 7˙999˙097 € (91%) |
Programme |
1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy) |
Code Call | H2020-SFS-2014-2 |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-15 to 2019-05-14 |
Take a look of project's partnership.
Euromix aim to develop an experimentally verified, tiered strategy for the risk assessment of mixtures of multiple chemicals derived from multiple sources across different life stages. The project takes account of the gender dimension and balances the risk of chemicals present in foods against the benefits of those foods. Important concepts for this new strategy are prioritisation criteria for chemicals based on their exposure and hazard characteristics and evaluation of the role of mode of action in grouping chemicals into cumulative assessment groups. In-silico and in-vitro tools will be developed and verified against in-vivo experiments, with focus on four selected endpoints (liver, hormones, development and immunology) to provide a full proof-of-principle. The EuroMix project will result in an innovative platform of bioassays for mixture testing and refined categorisation of chemicals in cumulative assessment groups. New hazard and exposure models will be embedded in a model toolbox, made available for stakeholders through an openly accessible web-based platform. Access to the web-based tools will be facilitated by training. Criteria will be set and guidance will be written on how to use and implement the tiered test strategy. Dissemination and harmonisation of the approach within EU, Codex Alimentarius, and WHO will be achieved by involving a.o. WHO and US-EPA in the project and by the participation of experts playing a key role in helping establish international food safety policies. It is expected that the new mechanism-based strategy, the bioassay platform, the openly accessible web-based model toolbox, and clear guidance on a tiered hazard and exposure test and risk assessment strategy will boost innovation in the public and private sector, provide a sound scientific basis for managing risks to public health from chemical mixtures, ultimately reduce the use of laboratory animals, and support the global discussion of risk assessment policies for mixtures.
Specific recommendations regarding implementation of a mechanism-based test strategy for liver, developmental and endocrine for OECD | Documents, reports | 2020-04-22 09:35:07 |
Report on the comparative outcome of using new mechanism-based testing and consequences for animal testing and uncertainties in risk assessment | Documents, reports | 2020-04-22 09:35:07 |
Report of WHO consultation workshop and feasibility study | Documents, reports | 2020-04-22 09:35:07 |
Minutes of meetings with External Advisory Board | Documents, reports | 2020-04-22 09:35:07 |
Scientific paper ready for submission describing the PB-PK/D model approach | Documents, reports | 2020-04-22 09:35:07 |
Scientific article ready for publication describing the method to identify mixtures | Documents, reports | 2020-04-22 09:35:06 |
Report with recommendation for OECD and other international organisations | Documents, reports | 2020-04-22 09:35:07 |
Scientific article describing the PB-PK model for combined exposures | Documents, reports | 2020-04-22 09:35:06 |
Scientific paper ready for submission describing biomarker study | Documents, reports | 2020-04-22 09:35:07 |
Final version of EuroMix model toolbox including hazard and PB-PK/D models | Other | 2020-04-22 09:35:07 |
PB-PK/D modelling for the index compound of the chosen endpoints | Other | 2020-04-22 09:35:06 |
Minutes of meetings with Scientific Advisory Board | Documents, reports | 2020-04-22 09:35:07 |
Scientific article ready for submission describing the results of the in vitro testing of mixtures | Documents, reports | 2020-04-22 09:35:07 |
Report on stakeholder workshop 1 | Documents, reports | 2020-04-22 09:35:07 |
Report describing the methodology and results of the refine and retain approach | Documents, reports | 2020-04-22 09:35:07 |
Demonstration tool cumulative exposure assessment | Demonstrators, pilots, prototypes | 2020-04-22 09:35:06 |
Scientific paper ready for submission on models and software for QIVIVE and AOP | Documents, reports | 2020-04-22 09:35:07 |
Scientific article ready for submission describing the in vitro testing strategy for immune toxicity | Documents, reports | 2020-04-22 09:35:06 |
Validation of the aggregated model and comparison with USA software | Documents, reports | 2020-04-22 09:35:07 |
Scientific article ready for submission describing the case study for aggregated exposure assessment | Documents, reports | 2020-04-22 09:35:06 |
Report on stakeholder workshop 2 | Documents, reports | 2020-04-22 09:35:07 |
Guidance on the use of the new strategy for tiered testing and assessment | Documents, reports | 2020-04-22 09:35:07 |
Plan for the dissemination and exploitation of the results from EuroMix | Documents, reports | 2020-04-22 09:35:07 |
Scientific article ready for publication balancing risk of mixtures against benefits | Documents, reports | 2020-04-22 09:35:07 |
Proceedings and training material from first training session for stakeholders | Demonstrators, pilots, prototypes | 2020-04-22 09:35:07 |
Scientific article ready for publication describing the in vivo studies | Documents, reports | 2020-04-22 09:35:06 |
Scientific paper ready for submission on the EuroMix toolbox and software | Documents, reports | 2020-04-22 09:35:07 |
The use of QSAR and TTC approaches to prioritise chemicals for mixtures | Documents, reports | 2020-04-22 09:35:07 |
Scientific article ready for submission describing the in vitro testing strategy for developmental/endocrine toxicity | Documents, reports | 2020-04-22 09:35:07 |
Minutes of meetings discussing harmonisation between Europe, EPA and WHO | Documents, reports | 2020-04-22 09:35:07 |
Proceedings and training material from second training session for stakeholders | Demonstrators, pilots, prototypes | 2020-04-22 09:35:07 |
Scientific article rady for submission on cumulative assessment of mixtures of several chemical classes | Documents, reports | 2020-04-22 09:35:07 |
Report on the needs and attitudes of stakeholders to the test strategy | Documents, reports | 2020-04-22 09:35:07 |
Position paper on gaps to be filled in existing legislation | Documents, reports | 2020-04-22 09:35:04 |
Demonstration prototype of EuroMix model toolbox (module priority setting). | Demonstrators, pilots, prototypes | 2020-04-22 09:35:04 |
Informative posters and booklets/brochures | Websites, patent fillings, videos etc. | 2020-04-22 09:35:04 |
CAG-specific PCR arrays | Other | 2020-04-22 09:35:04 |
Pan for managing and releasing open data | Open Research Data Pilot | 2020-04-22 09:35:04 |
Report usefulness of the TTC concept for risk assessment of mixtures | Documents, reports | 2020-04-22 09:35:04 |
Gender Plan | Documents, reports | 2020-04-22 09:35:04 |
Report describing cumulative assessment groups for a broad range of chemicals, based on information extracted from (literature) databases | Documents, reports | 2020-04-22 09:35:04 |
Report on the use of in-silico methods for the prioritisation of mixtures thereof | Documents, reports | 2020-04-22 09:35:04 |
Website for EuroMix project | Websites, patent fillings, videos etc. | 2020-04-22 09:35:04 |
Scientific article ready for submission describing the in vitro testing strategy for liver toxicity | Documents, reports | 2020-04-22 09:35:04 |
Take a look to the deliverables list in detail: detailed list of EuroMix deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Marc C. Kennedy, David G. Garthwaite, Waldo J. de Boer, Johannes W. Kruisselbrink Modelling aggregate exposure to pesticides from dietary and crop spray sources in UK residents published pages: 9892-9907, ISSN: 0944-1344, DOI: 10.1007/s11356-019-04440-7 |
Environmental Science and Pollution Research 26/10 | 2020-04-22 |
2018 |
Charles Laroche, Manoj Aggarwal, Hans Bender, Paul Benndorf, Barbara Birk, Jonathan Crozier, Gianni Dal Negro, Federica De Gaetano, Christian Desaintes, Iain Gardner, Bruno Hubesch, Amaia Irizar, David John, Vikas Kumar, Alfonso Lostia, Irene Manou, Mario Monshouwer, Boris P. Müller, Alicia Paini, Kirsty Reid, Timothy Rowan, Magdalini Sachana, Katrin Schutte, Catrina Stirling, Rob Taalman, Leon v Finding synergies for 3Rs – Toxicokinetics and read-across: Report from an EPAA partners\' Forum published pages: 5-21, ISSN: 0273-2300, DOI: 10.1016/j.yrtph.2018.08.006 |
Regulatory Toxicology and Pharmacology 99 | 2020-04-22 |
2016 |
van der Voet, H; de Boer, W; Kruisselbrink, J; van Lenthe, M; Crépet, A; Kennedy, M; Sprong, C; van Klaveren, J Deliverable 6.1 - Demonstration prototype of the EuroMix model toolbox published pages: , ISSN: , DOI: 10.5281/zenodo.1066087 |
1 | 2020-04-22 |
2016 |
van Klaveren, J; Sprong, C; Jongenelen, J; Husøy, T; Dirven, H; Peijnenburg, A Deliverable 1.2 - Data management plan published pages: , ISSN: , DOI: 10.5281/zenodo.1064629 |
1 | 2020-04-22 |
2016 |
Gunnlaugsdóttir, H; Jensen, S; Gylfadóttir, K; van Klaveren, J; Sporing, C; Hart, A; Nadal, M; Torrente, M; Garcia, T Deliverable 10.2 - Informative poster and booklet/brochure published pages: , ISSN: , DOI: 10.5281/zenodo.1066863 |
1 | 2020-04-22 |
2016 |
Rotter, S; Beronius, A; Hanberg, A; Zilliacus, J; Nikolopoulou, D; Machera, K; Solecki, R Deliverable 9.1 - Report on mixtures and implementation strategy in Europe – Assessment of chemical mixtures under consideration of current and future regulatory requirements and scientific approaches published pages: , ISSN: , DOI: 10.5281/zenodo.1067585 |
1 | 2020-04-22 |
2016 |
Kyriakopoulou, K; Nikolopoulou, D; Machera, K; Peijnenburg, A; Louca†Christodoulou, D; Hadjiloizou, P; Beronius, A; Håkansson, H; Hanberg, A; Eberini, I; Rorije, E Deliverable 2.1 - Report describing cumulative assessment groups for a broad range of chemicals, based on information extracted from (literature) databases published pages: , ISSN: , DOI: 10.5281/zenodo.1065327 |
1 | 2020-04-22 |
2016 |
van Klaveren, J; Sprong, C Deliverable 1.1 – Gender Plan published pages: , ISSN: , DOI: 10.5281/zenodo.1064620 |
1 | 2020-04-22 |
2018 |
Kennedy, Marc; Hart, Andrew; Roelofs, Victoria; Roelofs, Willem Elicitation Tool 3 published pages: , ISSN: , DOI: 10.5281/zenodo.1243619 |
2020-04-22 | |
2018 |
Elena Menegola, Francesca Metruccio, Maria Battistoni, Francesca Di Renzo, Angelo Moretto Concentration-response analysis of data obtained in mouse foetuses exposed in utero at E8 to azole antifungals (cyproconazole and triadimefon) alone or in mixture published pages: 21, ISSN: 0890-6238, DOI: 10.1016/j.reprotox.2018.06.080 |
Reproductive Toxicology 80 | 2020-04-22 |
2016 |
Gunnlaugsdóttir, H; Jensen, S; van Klaveren, J; Zilliacus, J; Durinck, S Deliverable 10.3 - Plan for the dissemination and exploitation of the results from EuroMix published pages: , ISSN: , DOI: 10.5281/zenodo.1066887 |
1 | 2020-04-22 |
2017 |
Sharon Compeer Effects of chemical mixtures on the development of the head skeleton of zebrafish embryos and on sexual development of the zebrafish published pages: , ISSN: , DOI: |
2020-04-22 | |
2016 |
Remco van der Kris Skeletal malformations in zebrafish embryos to assess mixture effects published pages: , ISSN: , DOI: |
2020-04-22 | |
2017 |
Ananditya Nugraha Analysis of Head Skeletal Malformation in Zebrafish Embryos for Chemical Mixture Assessment: phenotype and Mode of Action published pages: , ISSN: , DOI: |
2020-04-22 | |
2018 |
N. González, E. Schreiber, M. Torrente, V. Kumar, J.L. Domingo, M.M. Gómez Assessment of reproductive toxicity of male rats through maternal exposure to dienestrol published pages: S133, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.701 |
Toxicology Letters 295 | 2020-04-22 |
2018 |
S. Rotter, A. Beronius, A. R. Boobis, A. Hanberg, J. van Klaveren, M. Luijten, K. Machera, D. Nikolopoulou, H. van der Voet, J. Zilliacus, R. Solecki Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution published pages: 796-814, ISSN: 1040-8444, DOI: 10.1080/10408444.2018.1541964 |
Critical Reviews in Toxicology 48/9 | 2020-04-22 |
2019 |
Francesca Di Renzo, Francesca Metruccio, Maria Battistoni, Angelo Moretto, Elena Menegola Relative potency ranking of azoles altering craniofacial morphogenesis in rats: An in vitro data modelling approach published pages: 553-560, ISSN: 0278-6915, DOI: 10.1016/j.fct.2018.12.004 |
Food and Chemical Toxicology 123 | 2020-04-22 |
2018 |
Claudia Luckert, Albert Braeuning, Georges de Sousa, Sigrid Durinck, Efrosini S. Katsanou, Parthena Konstantinidou, Kyriaki Machera, Emanuela S. Milani, Ad A. C. M. Peijnenburg, Roger Rahmani, Andreja Rajkovic, Deborah Rijkers, Anastasia Spyropoulou, Marianna Stamou, Geert Stoopen, Shana Sturla, Bernd Wollscheid, Nathalie Zucchini-Pascal, Alfonso Lampen Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro : A Case Study with Cyproconazole published pages: 784-798, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.8b00112 |
Chemical Research in Toxicology 31/8 | 2020-04-22 |
2019 |
Amélie Crépet, Marie Vanacker, Corinne Sprong, Waldo de Boer, Urska Blaznik, Marc Kennedy, Chris Anagnostopoulos, Despo Louca Christodoulou, Jiřà Ruprich, Irena Rehurkova, José Luis Domingo, Bodil Hamborg Jensen, Francesca Metruccio, Angelo Moretto, Liesbeth Jacxsens, Pieter Spanoghe, David Senaeve, Hilko van der Voet, Jacob van Klaveren Selecting mixtures on the basis of dietary exposure and hazard data: application to pesticide exposure in the European population in relation to steatosis published pages: 291-306, ISSN: 1438-4639, DOI: 10.1016/j.ijheh.2018.12.002 |
International Journal of Hygiene and Environmental Health 222/2 | 2020-04-22 |
2016 |
Jeroen Meijer A method to evaluate skeletal malformations in zebrafish embryos (in view of mixture toxicity assessment) published pages: , ISSN: , DOI: |
2020-04-22 | |
2019 |
Maria Battistoni, Francesca Di Renzo, Elena Menegola, Frederic Yves Bois Quantitative AOP based teratogenicity prediction for mixtures of azole fungicides published pages: 72-81, ISSN: 2468-1113, DOI: 10.1016/j.comtox.2019.03.004 |
Computational Toxicology 11 | 2020-04-22 |
2018 |
M. Battistoni, F. Di Renzo, F. Metruccio, A. Moretto, E. Menegola Relative potency ranking of azoles altering cranio-facial morphogenesis in rat: an in vitro data modelling approach published pages: S193, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.868 |
Toxicology Letters 295 | 2020-04-22 |
2018 |
R.P. Sharma, M. Schuhmacher, V. Kumar PBPK/PD coupled HPG SB model to analyze the reproductive toxicity of EDs: Case study on mixture effects of DEHP and TCDD published pages: S249, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.1023 |
Toxicology Letters 295 | 2020-04-22 |
2016 |
Anke Boersma The effect of mixtures on the development of the zebrafish published pages: , ISSN: , DOI: |
2020-04-22 | |
2018 |
Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach published pages: 152-162, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.1217 |
Toxicology Letters 296 | 2020-04-22 |
2018 |
Jan-Jaap Sirks Mode of action definition in the context of mixture effects on skeletal development in zebrafish embryos published pages: , ISSN: , DOI: |
2020-04-22 | |
2015 |
Gunnlaugsdóttir, H; Jensen, S Deliverable 10.1 – Website for EuroMix project published pages: , ISSN: , DOI: 10.5281/zenodo.1066786 |
1 | 2020-04-22 |
2019 |
Paul van Ommeren Application of the dose addition model in complex mixture risk assessment published pages: , ISSN: , DOI: |
2020-04-22 | |
2019 |
Carina Sujan Gene expression patterns in zebrafish as an endpoint for the development of craniofacial aberrations caused by (environmental) pollutants published pages: , ISSN: , DOI: |
2020-04-22 | |
2018 |
Vivianne Veenma Analysis of the Mode of Action of chemicals inducing head skeletal malformations in zebrafish embryos published pages: , ISSN: , DOI: |
2020-04-22 | |
2019 |
Karrer, Cecile Consumer Exposure to Bisphenolic Compounds: Advancing Exposure and Pharmacokinetic Modeling published pages: , ISSN: , DOI: 10.3929/ethz-b-000336637 |
2020-04-22 | |
2019 |
Karrer, Cecile; von Goetz, Natalie; Hungerbühler, Konrad; Bokkers, Bas; Delmaar, Christiaan PACEM. Shiny beta version 0.9. published pages: , ISSN: , DOI: |
2020-04-22 | |
2018 |
Yvonne C. M. Staal, Jeroen Meijer, Remco J. C. van der Kris, Annamaria C. de Bruijn, Anke Y. Boersma, Eric R. Gremmer, Edwin P. Zwart, Piet K. Beekhof, Wout Slob, Leo T. M. van der Ven Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds published pages: 3549-3564, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2320-y |
Archives of Toxicology 92/12 | 2020-04-22 |
2017 |
Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar Developing integrated PBPK/PD coupled mechanistic pathway model (miRNA-BDNF): An approach towards system toxicology published pages: 79-91, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.08.003 |
Toxicology Letters 280 | 2020-04-22 |
2018 |
Monica Andreassen, Hege Hjertholm, Hubert Dirven and Trine Husøy Real-Life Exposure to Mixtures of Chemicals in the Euromix Human Biomonitoring Study: Results from Repeated 24-Hour Diaries Reporting the Use of Personal Care Products published pages: Society of Toxic, ISSN: , DOI: |
Toxicologist Database Toxicologist Database | 2020-04-22 |
2016 |
Thomas Roiss PBPK Modelling of BPA & BPF published pages: , ISSN: , DOI: |
2020-04-22 | |
2016 |
Nicole Cramer Physiologically based pharmacokinetic modelling of Bisphenol A in humans published pages: , ISSN: , DOI: |
2020-04-22 | |
2016 |
Sharma, R. P., Schuhmacher. M. Kumar V., Developing PBPK/PD model to characterize the mixture effect of TCDD and DEHP altering estradiol kinetic in ovary via crosstalk mechanism published pages: , ISSN: , DOI: |
2020-04-22 | |
2018 |
Charles Laroche, Manoj Aggarwal, Hans Bender, Paul Benndorf, Barbara Birk, Jonathan Crozier, Gianni Dal Negro, Federica De Gaetano, Christian Desaintes, Iain Gardner, Bruno Hubesch, Amaia Irizar, David John, Vikas Kumar, Alfonso Lostia, Irene Manou, Mario Monshouwer, Boris P. Müller, Alicia Paini, Kirsty Reid, Timothy Rowan, Magdalini Sachana, Katrin Schutte, Catrina Stirling, Rob Taalman, Leon van Aerts, Renate Weissenhorn, Ursula G. Sauer Finding synergies for 3Rs – Toxicokinetics and read-across: Report from an EPAA partners\' Forum published pages: 5-21, ISSN: 0273-2300, DOI: 10.1016/j.yrtph.2018.08.006 |
Regulatory Toxicology and Pharmacology 99 | 2020-04-22 |
2018 |
Monica Andreassen, Cecile Karrer, Natalie von Goetz, Amrit K. Sakhi, Hubert Dirven and Trine Husøy S01.04.07. Verification of Aggregated Exposure to Bisphenols from Diet and Cosmetics - The Human Biomonitoring Study from the EU Project Euromix published pages: , ISSN: , DOI: |
2020-04-22 | |
2016 |
Yaping Cai Exposure assessments of bisphenol S and F published pages: , ISSN: , DOI: |
2020-04-22 | |
2017 |
Patrick Fitzgerald Aggregate and cumulative exposure assessment of the endocrine disrupting chemicals 4-nonylphenol and bis(2-ethylhexyl)-phthalate published pages: , ISSN: , DOI: |
2020-04-22 | |
2018 |
H. Dirven, M. Andreassen, C. Karrer, N. von Goetz, A.K. Sakhi, T. Husøy Case study: Exposure to mixtures of chemicals in a human study and verification of aggregated exposure models with real-life data published pages: S2, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.011 |
Toxicology Letters 295 | 2020-04-22 |
2017 |
Frederic Y. Bois, Nazanin Golbamaki-Bakhtyari, Simona Kovarich, Cleo Tebby, Henry A. Gabb, Emmanuel Lemazurier High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors published pages: 77012, ISSN: 0091-6765, DOI: 10.1289/ehp742 |
Environmental Health Perspectives 125/7 | 2020-04-22 |
2018 |
Zhehui Chen Review on Cumulative Risk Assessments of Endocrine Disrupting Chemicals published pages: , ISSN: , DOI: |
2020-04-22 | |
2017 |
Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar Development and validation of PBPK model for DEHP and its metabolites: Application to cohort and case–control studies published pages: S284, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.07.796 |
Toxicology Letters 280 | 2020-04-22 |
2016 |
Klara Hauser Chemical-induced steatosis in an in vitro human liver cell model published pages: 1-36, ISSN: , DOI: |
Bachelor’s Thesis ETH Zurich, Department D-HEST | 2020-04-22 |
2016 |
Pascale Folini Cellular and molecular correlates of cyproconazole-induced steatosis and inflammation in an in vitro model of human liver cells published pages: 1-98, ISSN: , DOI: |
Master’s Thesis ETH Zurich, Department D-HEST | 2020-04-22 |
2017 |
Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar Review on crosstalk and common mechanisms of endocrine disruptors: Scaffolding to improve PBPK/PD model of EDC mixture published pages: 1-14, ISSN: 0160-4120, DOI: 10.1016/j.envint.2016.09.016 |
Environment International 99 | 2020-04-22 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EUROMIX" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "EUROMIX" are provided by the European Opendata Portal: CORDIS opendata.
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