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ALEC SIGNED

Aging Lungs in European Cohorts

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ALEC project word cloud

Explore the words cloud of the ALEC project. It provides you a very rough idea of what is the project "ALEC" about.

disability respiratory generate statistical decline preventive prediction risk policies score stratification fill excess patients disease 1990 adult poor health interactive 25000 underpin takes followed life genetic lung determinants identification exposure tool function course patterns strategies determinant population nutritional epigenetic cohort techniques integration cohorts occurrence adults biobanks occupational predictive methylation transgenerational modifiable lifestyle providers environmental validation appropriate combined children conception care copd disseminated online status base child generation day personalised dna examination cover gaps individual disciplines therapeutic data behavioural

Project "ALEC" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.alecstudy.org/
Twitter	http://www.twitter.com/AlecStudy
Total cost	7˙271˙433 €
EC max contribution	5˙534˙094 € (76%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2019-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙567˙232.00
2	UNIVERSITETET I BERGEN UNIVERSITETET I BERGEN Organization address address: MUSEPLASSEN 1 city: BERGEN postcode: 5020 website: www.uib.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (BERGEN)	participant	550˙000.00
3	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	496˙026.00
4	UNIVERSITA DEGLI STUDI DI VERONA UNIVERSITA DEGLI STUDI DI VERONA Organization address address: VIA DELL ARTIGLIERE 8 city: VERONA postcode: 37129 website: www.univr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VERONA)	participant	405˙000.00
5	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	401˙243.00
6	UNIVERSITY OF SOUTHAMPTON UNIVERSITY OF SOUTHAMPTON Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ website: http://www.southampton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHAMPTON)	participant	394˙712.00
7	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	379˙000.00
8	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	215˙880.00
9	LANDSPITALI UNIVERSITY HOSPITAL LANDSPITALI UNIVERSITY HOSPITAL Organization address address: Eiriksgata 5 city: REYKJAVIK postcode: 101 website: www.landspitali.is contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IS (REYKJAVIK)	participant	125˙000.00
10	FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL Organization address address: Calle Doctor Aiguader 88 city: BARCELONA postcode: 8003 website: www.creal.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	0.00
11	SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT Organization address address: SOCINSTRASSE 57 city: Basel postcode: CH-4002 website: www.swisstph.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Basel)	participant	0.00
12	UNIVERSITY OF MELBOURNE UNIVERSITY OF MELBOURNE Organization address address: PARKVILLEOFFICE OF THE VICE CHANCELLOR city: MELBOURNE postcode: 3010 website: www.unimelb.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (MELBOURNE)	participant	0.00

Map

Project objective

This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day. Following a comprehensive programme of risk factor identification we will generate a predictive risk score. The programme includes 1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors 5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health care providers. The work will provide an evidence base for risk identification at individual and population level that can underpin future preventive and therapeutic strategies and policies.

Deliverables

List of deliverables.
Study Website	Websites, patent fillings, videos etc.	2019-05-07 09:31:26
Pamphlet describing study aims and objectives available to partners for disemination	Documents, reports	2019-05-07 09:31:26
Data Managment Plan (early)	Documents, reports	2019-05-07 09:31:26
Consortium Publication Policy	Documents, reports	2019-05-07 09:31:26
Directory of stakeholders	Documents, reports	2019-05-07 09:31:26

Take a look to the deliverables list in detail: detailed list of ALEC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Toril MÃ¸rkve Knudsen, Faisal I. Rezwan, Yu Jiang, Wilfried Karmaus, Cecilie Svanes, John W. Holloway Transgenerational and intergenerational epigenetic inheritance in allergic diseases published pages: 765-772, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.07.007	Journal of Allergy and Clinical Immunology 142/3	2019-08-05
2019	Imboden, M Epigenome-wide association study of lung function level and its change published pages: , ISSN: 0903-1936, DOI:	European Respiratory Journal	2019-08-05
2019	Gabriela P Peralta, Elaine Fuertes, Raquel Granell, Osama Mahmoud, CÃ©lina Roda, Ignasi Serra, Deborah Jarvis, John Henderson, Judith Garcia-Aymerich Childhood Body Composition Trajectories and Adolescent Lung Function: Findings from the ALSPAC Study published pages: , ISSN: 1073-449X, DOI: 10.1164/rccm.201806-1168oc	American Journal of Respiratory and Critical Care Medicine	2019-07-30
2019	Ayoung Jeong, Medea Imboden, Akram Ghantous, Alexei Novoloaca, Anne-Elie Carsin, Manolis Kogevinas, Christian Schindler, Gianfranco Lovison, Zdenko Herceg, Cyrille Cuenin, Roel Vermeulen, Deborah Jarvis, AndrÃ© Amaral, Florian Kronenberg, Paolo Vineis, Nicole Probst-Hensch DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma published pages: 600, ISSN: 1660-4601, DOI: 10.3390/ijerph16040600	International Journal of Environmental Research and Public Health 16/4	2019-06-07
2019	Kai Triebner, Simone Accordini, Lucia Calciano, Ane Johannessen, BryndÃs BenediktsdÃ³ttir, Ersilia Bifulco, Pascal Demoly, Shyamali C. Dharmage, Karl A. Franklin, Judith Garcia-Aymerich, JosÃ© Antonio GullÃ³n Blanco, Joachim Heinrich, Mathias Holm, Debbie Jarvis, Rain JÃµgi, Eva Lindberg, JesÃºs MartÃnez-Moratalla, Nerea Muniozguren Agirre, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison, Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS) published pages: 29-34, ISSN: 0378-5122, DOI: 10.1016/j.maturitas.2018.11.007	Maturitas 120	2019-07-30
2019	Anne-Elie Carsin, Elaine Fuertes, Emmanuel Schaffner, Debbie Jarvis, Josep M. AntÃ³, Joachim Heinrich, Valeria Bellisario, Cecilie Svanes, Dirk Keidel, Medea Imboden, Joost Weyler, Dennis Nowak, Jesus Martinez-Moratalla, JosÃ©-Antonio GullÃ³n, JosÃ© Luis Sanchez Ramos, Seraina Caviezel, Anna Beckmeyer-Borowko, Chantal Raherison, Isabelle Pin, Pascal Demoly, Isa Cerveri, Simone Accordini, Thorarinn Restrictive spirometry pattern is associated with low physical activity levels. A population based international study published pages: 116-123, ISSN: 0954-6111, DOI: 10.1016/j.rmed.2018.11.017	Respiratory Medicine 146	2019-07-30
2018	Dinh S. Bui, Haydn E. Walters, John A. Burgess, Jennifer L. Perret, Minh Q. Bui, Gayan Bowatte, Adrian J. Lowe, Melissa A. Russell, Bruce R. Thompson, Garun S. Hamilton, Alan L. James, Graham G. Giles, Paul S. Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A. Frith, Katrina J. Allen, Michael J. Abramson, Caroline J. Lodge, Shyamali C. Dharmage Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade published pages: 1057-1066, ISSN: 2325-6621, DOI: 10.1513/annalsats.201806-374oc	Annals of the American Thoracic Society 15/9	2019-06-07
2018	Alessandro Marcon, Giancarlo Pesce, Lucia Calciano, Valeria Bellisario, Shyamali C. Dharmage, Judith Garcia-Aymerich, Thorarinn Gislasson, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, BÃ©nÃ©dicte Leynaert, Melanie C. Matheson, Pietro Pirina, Cecilie Svanes, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini Trends in smoking initiation in Europe over 40 years: A retrospective cohort study published pages: e0201881, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0201881	PLOS ONE 13/8	2019-07-30
2019	Giancarlo Pesce, Alessandro Marcon, Lucia Calciano, Jennifer L. Perret, Michael J. Abramson, Roberto Bono, Jean Bousquet, Alessandro G. Fois, Christer Janson, Deborah Jarvis, Rain JÃµgi, BÃ©nÃ©dicte Leynaert, Dennis Nowak, Vivi SchlÃ¼nssen, Isabel Urrutia-Landa, Giuseppe Verlato, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini Time and age trends in smoking cessation in Europe published pages: e0211976, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0211976	PLOS ONE 14/2	2019-07-30
2019	Ã–ssur Ingi Emilsson, Shadi Amid HÃ¤gg, Eva Lindberg, Karl A. Franklin, Kjell Toren, Bryndis Benediktsdottir, Thor Aspelund, Francisco GÃ³mez Real, BÃ©nÃ©dicte Leynaert, Pascal Demoly, Torben Sigsgaard, Jennifer Perret, Andrei Malinovschi, Deborah Jarvis, Judith Garcia-Aymerich, Thorarinn Gislason, Christer Janson Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms published pages: 00010-2019, ISSN: 2312-0541, DOI: 10.1183/23120541.00010-2019	ERJ Open Research 5/2	2019-07-30
2018	Osama Mahmoud, Raquel Granell, Kate Tilling, Cosetta Minelli, Judith Garcia-Aymerich, John W. Holloway, Adnan Custovic, Deborah Jarvis, Jonathan Sterne, John Henderson Association of Height Growth in Puberty with Lung Function. A Longitudinal Study published pages: 1539-1548, ISSN: 1073-449X, DOI: 10.1164/rccm.201802-0274oc	American Journal of Respiratory and Critical Care Medicine 198/12	2019-07-30
2019	Sheikh M Alif, Shyamali Dharmage, Geza Benke, Martine Dennekamp, John Burgess, Jennifer L Perret, Caroline Lodge, Stephen Morrison, David Peter Johns, Graham Giles, Lyle Gurrin, Paul S Thomas, John Llewelyn Hopper, Richard Wood-Baker, Bruce Thompson, Iain Feather, Roel Vermeulen, Hans Kromhout, Debbie Jarvis, Judith Garcia Aymerich, E Haydn Walters, Michael J Abramson, Melanie Claire Matheson Occupational exposure to solvents and lung function decline: A population based study published pages: thoraxjnl-2018-2, ISSN: 0040-6376, DOI: 10.1136/thoraxjnl-2018-212267	Thorax	2019-06-06
2018	Marianne LÃ¸nnebotn, Cecilie Svanes, Jannicke Igland, Karl A. Franklin, Simone Accordini, BryndÃs BenediktsdÃ³ttir, Hayat Bentouhami, JosÃ© A. G. Blanco, Roberto Bono, Angelo Corsico, Pascal Demoly, Shyamali Dharmage, Sandra Dorado Arenas, Judith Garcia, Joachim Heinrich, Mathias Holm, Christer Janson, Debbie Jarvis, BÃ©nÃ©dicte Leynaert, JesÃºs Martinez-Moratalla, Dennis Nowak, Isabelle Pin, Chantal Raherison-Semjen, Jose Luis SÃ¡nchez-Ramos, Vivi SchlÃ¼nssen, Svein Magne Skulstad, Julia Dratva, Francisco GÃ³mez Real Body silhouettes as a tool to reflect obesity in the past published pages: e0195697, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0195697	PLOS ONE 13/4	2019-05-24
2017	Dipender Gill, Nuala A. Sheehan, Matthias Wielscher, Nick Shrine, Andre F. S. Amaral, John R. Thompson, Raquel Granell, BÃ©nÃ©dicte Leynaert, Francisco GÃ³mez Real, Ian P. Hall, Martin D. Tobin, Juha Auvinen, Susan M. Ring, Marjo-Riitta Jarvelin, Louise V. Wain, John Henderson, Deborah Jarvis, Cosetta Minelli Age at menarche and lung function: a Mendelian randomization study published pages: 701-710, ISSN: 0393-2990, DOI: 10.1007/s10654-017-0272-9	European Journal of Epidemiology 32/8	2019-05-24
2017	Erla BjÃ¶rnsdÃ³ttir, Christer Janson, Eva Lindberg, Erna Sif Arnardottir, BryndÃs BenediktsdÃ³ttir, Judith Garcia-Aymerich, Anne Elie Carsin, Francisco GÃ³mez Real, Kjell TorÃ©n, Joachim Heinrich, Dennis Nowak, JosÃ© Luis SÃ¡nchez-Ramos, Pascal Demoly, Sandra Dorado Arenas, Ramon Coloma Navarro, Vivi SchlÃ¼nssen, Chantal Raherison, Debbie L Jarvis, Thorarinn Gislason Respiratory symptoms are more common among short sleepers independent of obesity published pages: e000206, ISSN: 2052-4439, DOI: 10.1136/bmjresp-2017-000206	BMJ Open Respiratory Research 4/1	2019-05-24
2017	R. J. Bertelsen, M. Rava, A. E. Carsin, S. Accordini, B. BenediktsdÃ³ttir, J. Dratva, K. A. Franklin, J. Heinrich, M. Holm, C. Janson, A. Johannessen, D. L. Jarvis, R. Jogi, B. Leynaert, D. Norback, E. R. Omenaas, C. Raherison, J. L. SÃ¡nchez-Ramos, V. SchlÃ¼nssen, T. Sigsgaard, S. C. Dharmage, C. Svanes Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring published pages: 627-638, ISSN: 0954-7894, DOI: 10.1111/cea.12906	Clinical & Experimental Allergy 47/5	2019-05-24
2017	Dinh S. Bui, John A. Burgess, Adrian J. Lowe, Jennifer L. Perret, Caroline J. Lodge, Minh Bui, Stephen Morrison, Bruce R. Thompson, Paul S. Thomas, Graham G. Giles, Judith Garcia-Aymerich, Debbie Jarvis, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthmaâ€“Chronic Obstructive Pulmonary Disease Overlap Syndrome published pages: 39-46, ISSN: 1073-449X, DOI: 10.1164/rccm.201606-1272oc	American Journal of Respiratory and Critical Care Medicine 196/1	2019-05-24
2018	Melanie Matheson, Gayan Bowatte, Jennifer Perret, Adrian Lowe, Chamara Senaratna, Graham Hall, Nick de Klerk, Louise Keogh, Christine McDonald, Nilakshi T Waidyatillake, Peter Sly, Deborah Jarvis, Michael Abramson, Caroline Lodge, Shyamali Dharmage Prediction models for the development of COPD: a systematic review published pages: 1927-1935, ISSN: 1178-2005, DOI: 10.2147/COPD.S155675	International Journal of Chronic Obstructive Pulmonary Disease Volume 13	2019-05-14
2017	Vanessa Garcia-Larsen, James F. Potts, Ernst Omenaas, Joachim Heinrich, Cecilie Svanes, Judith Garcia-Aymerich, Peter G. Burney, DeborahÂ L. Jarvis Dietary antioxidants and 10-year lung function decline in adults from the ECRHS survey published pages: 1602286, ISSN: 0903-1936, DOI: 10.1183/13993003.02286-2016	European Respiratory Journal 50/6	2019-05-16
2017	Matthew Machin, AndrÃ© F. S. Amaral, Matthias Wielscher, Faisal I. Rezwan, Medea Imboden, Marjo-Riitta Jarvelin, Ian M. Adcock, Nicole Probst-Hensch, John W. Holloway, Deborah L. Jarvis Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies published pages: , ISSN: 1471-2466, DOI: 10.1186/s12890-017-0397-3	BMC Pulmonary Medicine 17/1	2019-05-16
2018	Cosetta Minelli, Diana A. van der Plaat, BÃ©nÃ©dicte Leynaert, Raquel Granell, Andre F. S. Amaral, Miguel Pereira, Osama Mahmoud, James Potts, Nuala A. Sheehan, Jack Bowden, John Thompson, Debbie Jarvis, George Davey Smith, John Henderson Age at puberty and risk of asthma: A Mendelian randomisation study published pages: e1002634, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002634	PLOS Medicine 15/8	2019-05-14
2018	Elaine Fuertes, Anne-Elie Carsin, Josep M AntÃ³, Roberto Bono, Angelo Guido Corsico, Pascal Demoly, Thorarinn Gislason, JosÃ©-Antonio GullÃ³n, Christer Janson, Deborah Jarvis, Joachim Heinrich, Mathias Holm, BÃ©nÃ©dicte Leynaert, Alessandro Marcon, JesÃºs Martinez-Moratalla, Dennis Nowak, Silvia Pascual Erquicia, Nicole M Probst-Hensch, Chantal Raherison, Wasif Raza, Francisco GÃ³mez Real, Melissa Russell, JosÃ© Luis SÃ¡nchez-Ramos, Joost Weyler, Judith Garcia Aymerich Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study published pages: 376-384, ISSN: 0040-6376, DOI: 10.1136/thoraxjnl-2017-210947	Thorax 73/4	2019-05-16
2015	Cosetta Minelli, Gianluca Baio Value of Information: A Tool to Improve Research Prioritization and Reduce Waste published pages: e1001882, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1001882	PLOS Medicine 12/9	2019-05-24

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