NEPHSTROM SIGNED
Novel Stromal Cell Therapy for Diabetic Kidney Disease
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0NEPHSTROM project word cloud
Explore the words cloud of the NEPHSTROM project. It provides you a very rough idea of what is the project "NEPHSTROM" about.
Project "NEPHSTROM" data sheet
The following table provides information about the project.
| Coordinator |
NATIONAL UNIVERSITY OF IRELAND GALWAY
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Project website | http://nephstrom.eu |
| Total cost | 5˙994˙373 € |
| EC max contribution | 5˙994˙373 € (100%) |
| Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
| Code Call | H2020-PHC-2014-two-stage |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-05-01 to 2020-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | NATIONAL UNIVERSITY OF IRELAND GALWAY | IE (Galway) | coordinator | 1˙367˙830.00 |
| 2 | TERUMO BCT EUROPE NV | BE (ZAVENTEM) | participant | 599˙812.00 |
| 3 | ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI | IT (MILANO) | participant | 547˙902.00 |
| 4 | AZIENDA OSPEDALIERA PAPA GIOVANNI XXIII | IT (BERGAMO) | participant | 546˙472.00 |
| 5 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 523˙568.00 |
| 6 | NHS BLOOD AND TRANSPLANT | UK (WATFORD) | participant | 450˙000.00 |
| 7 | UNIVERSITY HOSPITAL BIRMINGHAM NHS FOUNDATION TRUST | UK (BIRMINGHAM) | participant | 431˙875.00 |
| 8 | BELFAST HEALTH AND SOCIAL CARE TRUST | UK (BELFAST) | participant | 415˙000.00 |
| 9 | ORBSEN THERAPEUTICS LIMITED | IE (Galway) | participant | 396˙912.00 |
| 10 | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN | DE (MUENCHEN) | participant | 365˙000.00 |
| 11 | PINTAIL LTD | IE (Blackrock) | participant | 200˙000.00 |
| 12 | THE QUEEN'S UNIVERSITY OF BELFAST | UK (BELFAST) | participant | 150˙000.00 |
Map
Project objective
Type 2 diabetes will affect >500 million adults by 2040 and its secondary complications will generate enormous socioeconomic costs - in particular, diabetic kidney disease (DKD), which is already the most common cause of chronic kidney disease. DKD is associated with greatly increased mortality and frequently progresses to end stage renal failure. Pharmacotherapy, dialysis and transplantation represent the mainstay treatments for DKD but are costly and provide only limited protection against adverse outcomes. Mesenchymal Stromal Cell (MSC) therapy is a promising approach to halting the progression of DKD toward end-stage renal failure and may also have ancillary benefits in Type 2 diabetes. In preliminary research, we have demonstrated that a single dose of MSC simultaneously improves kidney function (glomerular filtration rate and albuminuria) as well as hyperglycaemia in animals with DKD. NEPHSTROM will conduct a multi-centre, placebo-controlled clinical trial of a novel MSC therapy for stabilization of progressive DKD, leading to superior clinical outcomes and long-term socioeconomic benefit. A key enabler for this trial is a novel MSC population (CD362MSC, trade name ORBCEL-M) which delivers higher purity and improved characterisation compared to conventional plastic-adherent MSC. The NEPHSTROM Phase 1b/2a clinical trial will investigate the safety, tolerability and preliminary efficacy of a single intravenous infusion of allogeneic ORBCEL-M versus placebo in adults with progressive DKD. NEPHSTROM investigators will also determine the bio-distribution, mechanisms of action, immunological effects and economic impacts associated with ORBCEL-M therapy for DKD. This research will critically inform the optimal design of subsequent Phase 3 trials of ORBCEL-M. Stabilising progressive DKD through NEPHSTROM’s next-generation MSC therapy will reduce the high all-cause mortality and end-stage renal failure risk in people with this chronic non-communicable disease
Deliverables
| Website | Websites, patent fillings, videos etc. | 2020-01-24 09:01:41 |
| Dissemination materials | Websites, patent fillings, videos etc. | 2020-01-24 09:01:41 |
Take a look to the deliverables list in detail: detailed list of NEPHSTROM deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Manuel Alfredo Podestà , Giuseppe Remuzzi, Federica Casiraghi Mesenchymal Stromal Cells for Transplant Tolerance published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01287 |
Frontiers in Immunology 10 | 2020-01-24 |
| 2018 |
Nga T. Q. Nguyen, Paul Cockwell, Alexander P. Maxwell, Matthew Griffin, Timothy O’Brien, Ciaran O’Neill Chronic kidney disease, health-related quality of life and their associated economic burden among a nationally representative sample of community dwelling adults in England published pages: e0207960, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0207960 |
PLOS ONE 13/11 | 2020-01-24 |
| 2018 |
Siobhan M. Hamon, Tomás P. Griffin, Md Nahidul Islam, Deirdre Wall, Matthew D. Griffin, Paula M. O’Shea Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD) published pages: , ISSN: 1434-6621, DOI: 10.1515/cclm-2018-0534 |
Clinical Chemistry and Laboratory Medicine (CCLM) 0/0 | 2020-01-24 |
| 2018 |
A. Liew, C. Baustian, D. Thomas, E. Vaughan, C. Sanz-Nogués, M. Creane, X. Chen, S. Alagesan, P. Owens, J. Horan, P. Dockery, M. D. Griffin, A. Duffy, T. O’Brien Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody published pages: 96368971878486, ISSN: 0963-6897, DOI: 10.1177/0963689718784862 |
Cell Transplantation | 2020-01-24 |
| 2019 |
Tomás Griffin, Md Islam, Liam Blake, Marcia Bell, Matthew Griffin, Paula O’Shea Effect of Sodium Glucose Co-Transporter-2 Inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus published pages: 91-99, ISSN: 0018-5043, DOI: 10.1055/a-0794-7026 |
Hormone and Metabolic Research 51/02 | 2020-01-24 |
| 2018 |
Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology published pages: 362-375, ISSN: 1046-6673, DOI: 10.1681/ASN.2017070781 |
Journal of the American Society of Nephrology 29/2 | 2020-01-24 |
| 2018 |
Muhammad Mosaraf Hossain, David Barua, Vahid Arabkari, Nahidul Islam, Ananya Gupta, Sanjeev Gupta Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24451 |
Oncotarget 9/14 | 2020-01-24 |
| 2018 |
Eanna P Connaughton, Serika Naicker, Shirley A Hanley, Stephanie M Slevin, John K Eykelenboom, Noel F Lowndes, Timothy O\'Brien, Rhodri Ceredig, Matthew D Griffin, Michael C Dennedy Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression published pages: , ISSN: 0818-9641, DOI: 10.1111/imcb.12032 |
Immunology and Cell Biology | 2020-01-24 |
| 2018 |
Paul Lohan, Oliver Treacy, Maurice Morcos, Ellen Donohoe, Yvonne O\'donoghue, Aideen E. Ryan, Stephen J. Elliman, Thomas Ritter, Matthew D. Griffin Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat published pages: , ISSN: 1066-5099, DOI: 10.1002/stem.2840 |
STEM CELLS | 2020-01-24 |
| 2017 |
William P. Martin, Tomás P. Griffin, David W. Lappin, Damian G. Griffin, John P. Ferguson, Timothy O\'Brien, Matthew D. Griffin Influence of Referral to a Combined Diabetology and Nephrology Clinic on Renal Functional Trends and Metabolic Parameters in Adults With Diabetic Kidney Disease published pages: 150-160, ISSN: 2542-4548, DOI: 10.1016/j.mayocpiqo.2017.07.003 |
Mayo Clinic Proceedings: Innovations, Quality & Outcomes 1/2 | 2020-01-24 |
| 2018 |
Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi Mesenchymal Stromal Cells for AKI after Cardiac Surgery published pages: ASN.2017111207, ISSN: 1046-6673, DOI: 10.1681/ASN.2017111207 |
Journal of the American Society of Nephrology | 2020-01-24 |
| 2018 |
Senthilkumar Alagesan, Clara Sanz-Nogués, Xizhe Chen, Michael Creane, Thomas Ritter, Rhodri Ceredig, Timothy O\'Brien, Matthew D Griffin Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells published pages: 536-548, ISSN: 0818-9641, DOI: 10.1111/imcb.12024 |
Immunology and Cell Biology 96/5 | 2020-01-24 |
| 2016 |
Onkar P. Kulkarni, Julia Lichtnekert, Hans-Joachim Anders, Shrikant R. Mulay The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is “Inflammation†Always Inflammation? published pages: 1-9, ISSN: 0962-9351, DOI: 10.1155/2016/2856213 |
Mediators of Inflammation 2016 | 2020-01-24 |
| 2017 |
Paola Romagnani, Giuseppe Remuzzi, Richard Glassock, Adeera Levin, Kitty J. Jager, Marcello Tonelli, Ziad Massy, Christoph Wanner, Hans-Joachim Anders Chronic kidney disease published pages: 17088, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.88 |
Nature Reviews Disease Primers 3 | 2020-01-24 |
| 2016 |
Tomás P. Griffin, William Patrick Martin, Nahidul Islam, Timothy O’Brien, Matthew D. Griffin The Promise of Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-016-0734-6 |
Current Diabetes Reports 16/5 | 2020-01-24 |
| 2017 |
Paul Lohan, Oliver Treacy, Matthew D. Griffin, Thomas Ritter, Aideen E. Ryan Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning? published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01626 |
Frontiers in Immunology 8 | 2020-01-24 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NEPHSTROM" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "NEPHSTROM" are provided by the European Opendata Portal: CORDIS opendata.