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MULTIMOT SIGNED

Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MULTIMOT project word cloud

Explore the words cloud of the MULTIMOT project. It provides you a very rough idea of what is the project "MULTIMOT" about.

collects node annotates morphogenesis 2014 wound elixir infrastructure meet benefited enormously 32 unmet standardized peripheral cancer community methodology content exchange bioinformatics throughput ecosystem function extensible treatment guiding fundamental motility integrative proof clinical free urgent post science data leukocyte diagnosis advancing direct regarding healing cell immune lab standardization source submission algorithms blood medically phc disseminates standards form tools largely instrumentation migration extraction foundation central repository few de last multiplexing metastasis inter patient biomedical facto personalized formats organoids emerged solutions meta construct

Project "MULTIMOT" data sheet

The following table provides information about the project.

Coordinator	VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://multimot.org/
Total cost	2˙999˙354 €
EC max contribution	2˙999˙354 € (100%)
Programme	1. H2020-EU.3.1.6. (Health care provision and integrated care)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VIB VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	coordinator	576˙750.00
2	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	490˙680.00
3	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	420˙812.00
4	UNIVERSITY OF DUNDEE UNIVERSITY OF DUNDEE Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN website: www.dundee.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (DUNDEE)	participant	364˙520.00
5	UNIVERSITAETSKLINIKUM ESSEN UNIVERSITAETSKLINIKUM ESSEN Organization address address: HUFELANDSTRASSE 55 city: ESSEN postcode: 45147 website: www.uk-essen.de/frauenklinik/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ESSEN)	participant	347˙038.00
6	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	340˙750.00
7	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	144˙052.00
8	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	133˙750.00
9	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	118˙375.00
10	Idea Bio-Medical Ltd. Idea Bio-Medical Ltd. Organization address address: Prof. Bergman St. 2 city: Rehovot postcode: 76705 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (Rehovot)	participant	62˙625.00

Map

Project objective

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.

Deliverables

List of deliverables.
Implementation of REST and BioMart services	Documents, reports	2019-03-22 09:53:17
Report on the development of multiscale analysis algorithms for complex multivariate data	Documents, reports	2019-03-22 09:54:01
Standardized procedures and data sets from patient-derived tumor and immune cell models	Documents, reports	2019-03-22 09:54:20
Report on the development of meta-scale analysis algorithms	Documents, reports	2019-03-22 09:53:48
Submission of the second position paper	Documents, reports	2019-03-22 09:54:14
Implementation of a discussion forum module	Documents, reports	2019-03-22 09:53:36
Release of an open semantic validation framework for MIACME compliance verification	Documents, reports	2019-03-22 09:52:31
Report on the two CMSO workshops and proceedings manuscripts in year 2	Documents, reports	2019-03-22 09:54:08
Release of a medical-oriented knowledgebase	Documents, reports	2019-03-22 09:53:43
Support for the CMSO standards in IBâ€™s relevant commercial software	Documents, reports	2019-03-21 16:29:15
Implementation of automated MIACME compliance validation	Documents, reports	2019-03-22 09:53:30
Release of a version of CellMissy that can import data from the public repository	Documents, reports	2019-03-22 09:52:37
Report on the maintenance and updates carried out on the standard, and the plans for further support beyond project end	Documents, reports	2019-03-21 16:29:33
Creation of project website	Documents, reports	2019-03-22 17:18:30
Release of the standard format for cell migration data	Documents, reports	2019-03-22 17:18:22
Release of standards compliant CellMissy version	Documents, reports	2019-03-25 10:00:11
Report on the structures and approaches set up for maintenance and updates to the standards	Documents, reports	2019-03-25 10:00:30
Submission of the first position paper	Documents, reports	2019-03-25 10:00:21
Project progress report for Year 1	Documents, reports	2019-03-22 17:18:28
Report on the development of quality control algorithms	Documents, reports	2019-03-25 10:00:21
Creation of the Cell Migration Standardization Organization (CMSO)	Documents, reports	2019-03-22 17:18:28
Release of software libraries for the standard format	Documents, reports	2019-03-25 10:00:07
First release of the functional repository	Documents, reports	2019-03-22 17:18:32
Release of the MIACME minimal reporting requirements	Documents, reports	2019-03-25 10:00:31
Report on the two CMSO workshops and proceedings manuscripts in year 1	Documents, reports	2019-03-25 10:00:21
Report on experimental procedures and multi-parameter analysis from tumor and immune cell models for computational multiscale analysis	Documents, reports	2019-03-25 10:00:16
Report on the development of dedicated cell migration feature extraction algorithms	Documents, reports	2019-03-22 17:18:29
Project progress report for Year 2	Documents, reports	2019-03-25 10:00:23
Report on the creation of a CV	Documents, reports	2019-03-22 17:18:27
Requirements analysis for the cell migration repository	Documents, reports	2019-03-25 10:00:21
Standardized, refined procedures and data sets from tumor and immune cell models for computational multi-scale analysis	Documents, reports	2019-03-25 10:00:25
Report on the two CMSO workshops and proceedings manuscripts in year 3	Documents, reports	2019-03-21 16:29:17
Project progress report for Year 3	Documents, reports	2019-03-21 16:29:27

Take a look to the deliverables list in detail: detailed list of MULTIMOT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Gwendolien Sergeant, Lennart Martens, Marleen Van Troys, Paola Masuzzo DoRes within CellMissy: dose-response analysis on cell migration and related data published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty634	Bioinformatics	2019-05-24
2017	Peter Friedl, Roberto Mayor Tuning Collective Cell Migration by Cellâ€“Cell Junction Regulation published pages: a029199, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a029199	Cold Spring Harbor Perspectives in Biology 9/4	2019-05-24
2017	Eleanor Williams, Josh Moore, Simon W Li, Gabriella Rustici, Aleksandra Tarkowska, Anatole Chessel, Simone Leo, BÃ¡lint Antal, Richard K Ferguson, Ugis Sarkans, Alvis Brazma, Rafael E Carazo Salas, Jason R Swedlow Image Data Resource: a bioimage data integration and publication platform published pages: 775-781, ISSN: 1548-7091, DOI: 10.1038/nmeth.4326	Nature Methods 14/8	2019-05-24
2016	Whetzel, Patricia L; Overton, James A.; Phillip Lord; Yu Lin; Jennifer Fostel; Monnie McGee; Anita Bandrowski; Ryan Brinkman; Stoeckert, Christian J.; Chibucos, Marcus C.; Bjoern Peters; Helen Parkinson; Soldatova, Larisa N; James Malone; Taylor, Chris F; Mathias Brochhausen; Lister, Allyson L; Kevin Clancy; Philippe Rocca-Serra; Mark Jensen; Susanna-Assunta Sansone; Carlo Torniai; Michel Dumontier; Haendel, Melissa A.; Barry Smith; Tina Hernandez-Boussard; Alejandra Gonzalez-Beltran; Daniel Schober; Elisabetta Manduchi; Randi Vita; Jessica A Turner; Brush, Matthew H; Dirk Derom; Bill Bug; MÃ©lanie Courtot; Jie Zheng; Mervi Heiskanen; Norman Morrison; Scheuermann, Richard H; Yongqun He; Gilberto Fragoso; Frank Gibson; Alan Ruttenberg; Liju Fan The ontology for biomedical investigations published pages: p e0154556, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0154556	PLoS ONE 11	2019-05-24
2017	Paola Masuzzo, Lynn Huyck, Aleksandra Simiczyjew, Christophe Ampe, Lennart Martens, Marleen Van Troys An end-to-end software solution for the analysis of high-throughput single-cell migration data published pages: 42383, ISSN: 2045-2322, DOI: 10.1038/srep42383	Scientific Reports 7	2019-05-24
2016	Jonathan P. Tennant, FranÃ§ois Waldner, Damien C. Jacques, Paola Masuzzo, Lauren B. Collister, Chris. H. J. Hartgerink The academic, economic and societal impacts of Open Access: an evidence-based review published pages: 632, ISSN: 2046-1402, DOI: 10.12688/f1000research.8460.1	F1000Research 5	2019-05-24
2017	Anika Klingberg, Anja Hasenberg, Isis Ludwig-Portugall, Anna Medyukhina, Linda MÃ¤nn, Alexandra Brenzel, Daniel R. Engel, Marc Thilo Figge, Christian Kurts, Matthias Gunzer Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy published pages: 452-459, ISSN: 1046-6673, DOI: 10.1681/ASN.2016020232	Journal of the American Society of Nephrology 28/2	2019-05-24

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