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EDC-MixRisk SIGNED

Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EDC-MixRisk project word cloud

Explore the words cloud of the EDC-MixRisk project. It provides you a very rough idea of what is the project "EDC-MixRisk" about.

health decision doubt exposure endocrine experts documentation approached molecular risks mechanisms meet chemical edcs human chemicals urgent tools life designed cooperation systematic epidemiological regarding models multiple mixrisk biology metabolism humans neurodevelopment disrupting safe scientific integrating pose disruptive experimental body generation refinement epidemiology mixtures single societal risk effort anthropogenic domains handled identification supports toxicology combined underlying sexual interdisciplinary outcomes framework adverse associations disorders wildlife transparent edc

Project "EDC-MixRisk" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://edcmixrisk.ki.se/
Total cost	6˙223˙330 €
EC max contribution	6˙223˙330 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2019-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙089˙181.00
2	KARLSTADS UNIVERSITET KARLSTADS UNIVERSITET Organization address address: UNIVERSITETSGATAN 2 city: KARLSTAD postcode: 651 88 website: www.kau.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (KARLSTAD)	participant	1˙194˙481.00
3	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	585˙000.00
4	ISTITUTO EUROPEO DI ONCOLOGIA SRL ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 website: www.ieo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	489˙000.00
5	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	450˙061.00
6	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	428˙436.00
7	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	418˙532.00
8	TERVEYDEN JA HYVINVOINNIN LAITOS TERVEYDEN JA HYVINVOINNIN LAITOS Organization address address: MANNERHEIMINTIE 166 city: HELSINKI postcode: 271 website: www.thl.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	350˙537.00
9	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	321˙250.00
10	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	316˙750.00
11	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Organization address address: ONE GUSTAVE L LEVY PLACE BOX 1075 city: NEW YORK postcode: 10029 6574 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	265˙570.00
12	OREBRO UNIVERSITY OREBRO UNIVERSITY Organization address address: FAKULTETSGATAN 1 city: OREBRO postcode: 70182 website: www.oru.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (OREBRO)	participant	252˙030.00
13	UNIVERSITAET LEIPZIG UNIVERSITAET LEIPZIG Organization address address: RITTERSTRASSE 26 city: LEIPZIG postcode: 4109 website: www.uni-Ieipzig.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LEIPZIG)	participant	62˙500.00

Map

Project objective

A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns, there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particular in mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management. This project is designed to promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need for improved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risks for multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDC mixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimental toxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identification of EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth and metabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanisms and pathways underlying the associations between exposure and adverse health outcomes by the use and development of state-of-the-art experimental models and iii) Development of a transparent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societal impact, thus promoting better risk management for EDCs and their mixtures.

Deliverables

List of deliverables.
Report on how to ensure workability of the IPCS definition of EDCs	Documents, reports	2019-11-20 11:44:50
Report on a novel framework for risk assessment of mixtures	Documents, reports	2019-11-20 11:44:50
4th Report from the Scientific Advisory Board meeting	Documents, reports	2019-11-20 11:44:50
Report EDC mixtures III	Documents, reports	2019-11-20 11:44:50
Report on inclusive strategies for the regulatory implementation of risk assessment tools for EDC mixtures	Documents, reports	2019-11-20 11:44:50
3rd Report from the Scientific Advisory Board meeting	Documents, reports	2019-11-20 11:44:50
Data management plan document	Open Research Data Pilot	2019-11-20 11:44:50
Report on chemical levels in SELMA and Life Child.	Documents, reports	2019-11-20 11:44:50
Internal communication plan document	Documents, reports	2019-11-20 11:44:50
1st Dissemination activity and quality report	Documents, reports	2019-11-20 11:44:50
Report on critical EDC mixtures I	Documents, reports	2019-11-20 11:44:50
Comprehensive information about ECD-MixRisk in EN, SE, FR, DE, FI, GR, IT	Websites, patent fillings, videos etc.	2019-11-20 11:44:49
2nd Dissemination activity and quality report	Documents, reports	2019-11-20 11:44:50
Whitepaper on EDCs and health risks	Documents, reports	2019-11-20 11:44:50
2nd Report from the Scientific Advisory Board meeting	Documents, reports	2019-11-20 11:44:50
Meeting report of the WHO Chemical Risk Assessment Network	Documents, reports	2019-11-20 11:44:50
1st Report from Scientific Advisory Board meeting	Documents, reports	2019-11-20 11:44:50
Project guideline document	Documents, reports	2019-11-20 11:44:49
Launch of webpage	Websites, patent fillings, videos etc.	2019-11-20 11:44:49
Dissemination guideline	Documents, reports	2019-11-20 11:44:50
Report on doses and exposure regiments for experimental studies with mixtures I	Documents, reports	2019-11-20 11:44:49
Report on doses and exposure regiments for experimental studies with mixtures 0	Documents, reports	2019-11-20 11:44:49

Take a look to the deliverables list in detail: detailed list of EDC-MixRisk deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R. Tuck, Marcus O. D. SjÃ¶din, Johan Lindberg, Evangelos Bozas, JoÃ«lle RÃ¼egg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42377-6	Scientific Reports 9/1	2019-11-20
2019	Carlâ€Gustaf Bornehag, Efthymia Kitraki, Antonios Stamatakis, Emily Panagiotidou, Christina RudÃ©n, Huan Shu, Christian Lindh, Joelle Ruegg, Chris Gennings A Novel Approach to Chemical Mixture Risk Assessmentâ€”Linking Data from Populationâ€Based Epidemiology and Experimental Animal Tests published pages: , ISSN: 0272-4332, DOI: 10.1111/risa.13323	Risk Analysis	2019-11-20
2019	Petra Spirhanzlova, Michelle Leemans, Barbara A. Demeneix, Jean-Baptiste Fini Following Endocrine-Disrupting Effects on Gene Expression in Xenopus laevis published pages: pdb.prot098301, ISSN: 1559-6095, DOI: 10.1101/pdb.prot098301	Cold Spring Harbor Protocols 2019/7	2019-11-20
2018	Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie NÃ¸rager, JoÃ«lle RÃ¼egg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Ã…ke Bergman Current EU research activities on combined exposure to multiple chemicals published pages: 544-562, ISSN: 0160-4120, DOI: 10.1016/j.envint.2018.07.037	Environment International 120	2019-11-20
2018	Bilal B Mughal, Jean-Baptiste Fini, Barbara A Demeneix Thyroid-disrupting chemicals and brain development: an update published pages: R160-R186, ISSN: 2049-3614, DOI: 10.1530/EC-18-0029	Endocrine Connections 7/4	2019-11-20
2018	Ali Alavian-Ghavanini, Ping-I Lin, P. Monica Lind, Sabina RisÃ©n Rimfors, Margareta Halin Lejonklou, Linda Dunder, Mandy Tang, Christian Lindh, Carl-Gustaf Bornehag, JoÃ«lle RÃ¼egg Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29732-9	Scientific Reports 8/1	2019-11-20
2017	Jean-Baptiste Fini, Bilal B. Mughal, SÃ©bastien Le MÃ©vel, Michelle Leemans, MÃ©lodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A. Demeneix Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos published pages: 43786, ISSN: 2045-2322, DOI: 10.1038/srep43786	Scientific Reports 7	2019-11-20
2018	Ali Alavian-Ghavanini, JoÃ«lle RÃ¼egg Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods published pages: 38-45, ISSN: 1742-7835, DOI: 10.1111/bcpt.12878	Basic & Clinical Pharmacology & Toxicology 122/1	2019-11-20
2017	M. Hoffmann, S. Gebauer, M. NÃ¼chter, R. Baber, J. Ried, M. von Bergen, W. Kiess Endokrine Modulatoren published pages: 640-648, ISSN: 1436-9990, DOI: 10.1007/s00103-017-2551-8	Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 60/6	2019-11-20
2017	I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O SÃ¶der, K Svechnikov Androgenic potential of human fetal adrenals at the end of the first trimester published pages: 348-359, ISSN: 2049-3614, DOI: 10.1530/EC-17-0085	Endocrine Connections 6/6	2019-11-20
2017	Miriam N. Jacobs, Emma L. Marczylo, Carlos Guerrero-Bosagna, JoÃ«lle RÃ¼egg Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals published pages: 105-160, ISSN: 1543-5938, DOI: 10.1146/annurev-environ-102016-061111	Annual Review of Environment and Resources 42/1	2019-11-20
2016	Roland Solecki, Andreas Kortenkamp, Ã…ke Bergman, Ibrahim Chahoud, Gisela H. Degen, Daniel Dietrich, Helmut Greim, Helen HÃ¥kansson, Ulla Hass, Trine Husoy, Miriam Jacobs, Susan Jobling, Alberto Mantovani, Philip Marx-Stoelting, Aldert Piersma, Vera Ritz, Remy Slama, Ralf Stahlmann, Martin van den Berg, R. Thomas Zoeller, Alan R. Boobis Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement published pages: , ISSN: 0340-5761, DOI: 10.1007/s00204-016-1866-9	Archives of Toxicology	2019-11-20
2016	E. Kitraki, I. Nalvarte, A. Alavian-Ghavanini, J. RÃ¼egg Effects of pre- and post-natal exposure to bisphenol A on the stress system published pages: e1184775, ISSN: 2327-3747, DOI: 10.1080/23273747.2016.1184775	Endocrine Disruptors 4/1	2019-11-20
2016	Lars Lind, P. Monica Lind, Margareta H. Lejonklou, Linda Dunder, Ã…ke Bergman, Carlos Guerrero-Bosagna, Erik Lampa, Hong Kyu Lee, Juliette Legler, Angel Nadal, Youngmi Kim Pak, Richard P. Phipps, Laura N. Vandenberg, Daniel Zalko, Marlene Ã…gerstrand, Mattias Ã–berg, Bruce Blumberg, Jerrold J. Heindel, Linda S. Birnbaum Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic published pages: , ISSN: 0091-6765, DOI: 10.1289/ehp.1511115	Environmental Health Perspectives 124/5	2019-11-20

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