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ROBOX SIGNED

Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols (ROBOX)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ROBOX project word cloud

Explore the words cloud of the ROBOX project. It provides you a very rough idea of what is the project "ROBOX" about.

adh lab chemicals ktons catalytic screening industrial highest broad platform oxidative segment monooxygenases gt 16 routes kg types innovative functional reactions nutrition materials reductions ambient baeyer technologies economic markets pharma bio emissions temperature benign air raw monooxygenase plants enzymatic efficient limitations enzyme villiger introduction efficiency oxygen chemical oxidation substantial dehydrogenase economics viability catalyzed p450s ph 11 commercial sme mainly fine validated players alcohol molecular 60 enzymes functionalities price computational bvmos segments joint expression transformations industry plug lower aox 50 techno groups energy specialty ghg bug pressure added 1000 bulk larger optimal sustainability mild replication widening oxidase robox volume p450 justifies prepare

Project "ROBOX" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.h2020robox.eu/
Total cost	11˙159˙493 €
EC max contribution	8˙181˙676 € (73%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-LEIT-BIO-2014-1
Funding Scheme	IA
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	1˙062˙896.00
2	DSM CHEMICAL TECHNOLOGY R & D BV DSM CHEMICAL TECHNOLOGY R & D BV Organization address address: POSTSTRAAT 1 city: SITTARD postcode: 6135 KR website: www.dsm.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (SITTARD)	participant	762˙832.00
3	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Organization address address: TEMPLERGRABEN 55 city: AACHEN postcode: 52062 website: www.rwth-aachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	741˙418.00
4	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	705˙258.00
5	TECHNISCHE UNIVERSITAET GRAZ TECHNISCHE UNIVERSITAET GRAZ Organization address address: RECHBAUERSTRASSE 12 city: GRAZ postcode: 8010 website: www.tugraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	675˙415.00
6	UNIVERSIDAD AUTONOMA DE BARCELONA UNIVERSIDAD AUTONOMA DE BARCELONA Organization address address: CALLE CAMPUS UNIVERSITARIO SN CERDANYOLA V city: CERDANYOLA DEL VALLES postcode: 8290 website: http://www.uab.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CERDANYOLA DEL VALLES)	participant	489˙782.00
7	INNOSYN BV INNOSYN BV Organization address address: URMONDERBAAN 22 city: GELEEN postcode: 6167 RD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GELEEN)	participant	478˙362.00
8	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	472˙391.00
9	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	458˙296.00
10	UNIVERSITA DEGLI STUDI DI PAVIA UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PAVIA)	participant	447˙205.00
11	EVOXX TECHNOLOGIES GMBH EVOXX TECHNOLOGIES GMBH Organization address address: ALFRED NOBEL STRASSE 10 city: MONHEIM postcode: 40789 website: www.evocatal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MONHEIM)	participant	312˙025.00
12	CHEMSTREAM BVBA CHEMSTREAM BVBA Organization address address: DRIE EIKENSTRAAT 661 city: EDEGEM postcode: 2650 website: www.chemstream.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (EDEGEM)	participant	298˙812.00
13	ACIB GMBH ACIB GMBH Organization address address: KRENNGASSE 37/2 city: GRAZ postcode: 8010 website: www.acib.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	282˙278.00
14	C-LECTA GMBH C-LECTA GMBH Organization address address: PERLICKSTRASSE 5 city: LEIPZIG postcode: 4103 website: www.c-LEcta.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LEIPZIG)	participant	274˙952.00
15	GENENCOR INTERNATIONAL BV GENENCOR INTERNATIONAL BV Organization address address: ARCHIMEDESWEG 30 city: LEIDEN postcode: 2333 CN website: www.biosciences.dupont.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	265˙759.00
16	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	211˙232.00
17	PNO CONSULTANTS BV PNO CONSULTANTS BV Organization address address: LAAN VAN ZUID HOORN 15 city: RIJSWIJK postcode: 2289 DC website: www.pnoconsultants.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (RIJSWIJK)	participant	97˙370.00
18	DYADIC NEDERLAND BV DYADIC NEDERLAND BV Organization address address: NIEUWE KANAAL 7 S city: Wageningen postcode: 6709 PA website: www.dyadic.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Wageningen)	participant	89˙577.00
19	LentiKat's a.s. LentiKat's a.s. Organization address address: POD VINICI 83 city: STRAZ POD RALSKEM postcode: 471 27 website: www.lentikats.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (STRAZ POD RALSKEM)	participant	55˙810.00
20	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	0.00
21	GIVAUDAN SUISSE SA GIVAUDAN SUISSE SA Organization address address: CHEMIN DE LA PARFUMERIE 5 city: VERNIER postcode: 1214 website: www.givaudan.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (VERNIER)	participant	0.00

Map

Project objective

Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency.

In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants.

ROBOX is industry-driven with 2 major industrial players and 6 SME’s. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, “plug bug” expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).

Deliverables

List of deliverables.
Optimized enzyme production processes for ROBOX enzymes in bioreactor including DSP	Demonstrators, pilots, prototypes	2020-04-22 10:11:11
Overall analysis of environmental benefits and techno-economics of the processes and platform	Documents, reports	2020-04-22 10:11:11
96-well capillary electrophoreses screening system and first flow cytometer based screening system available	Demonstrators, pilots, prototypes	2020-04-22 10:11:11
Biocatalytic and structural exploration of P450-AX as well as generation of improved variants	Demonstrators, pilots, prototypes	2020-04-22 10:11:11
Quorum sensing technology and micro fluidics platform available	Demonstrators, pilots, prototypes	2020-04-22 10:11:10
Set of P450 enzymes with improved performance for hydroxylation of aromatics, alkenes and APIs and a set of API-sensors to enable P450 improvement	Demonstrators, pilots, prototypes	2020-04-22 10:11:10
Generation of a first flow cytometer based screening system for quantification of one product in the BM3 demonstration process through fluorogenic sensors	Demonstrators, pilots, prototypes	2020-04-22 10:11:10
Public website and newsletter, first press releases on the project scopes	Documents, reports	2020-04-22 10:11:09
Project leaflet in several languages	Documents, reports	2020-04-22 10:11:09
Completion of benchmarking protocol and flowsheets established for the case studies	Documents, reports	2020-04-22 10:11:09
New vector and host systems for enzyme coexpression	Demonstrators, pilots, prototypes	2020-04-22 10:11:10
First generation production strains for robust BVMOs	Demonstrators, pilots, prototypes	2020-04-22 10:11:09
Identification of genes predicted to encode relevant robust BVMOs and oxidases	Documents, reports	2020-04-22 10:11:09
Structural elucidation of relevant of BVMOs e.g. at least 3 new enzyme structures	Documents, reports	2020-04-22 10:11:10
Communication and dissemination plan	Documents, reports	2020-04-22 10:11:09
Installation of advisory boards	Other	2020-04-22 10:11:09
First generation production strains for microbial and human P450s	Demonstrators, pilots, prototypes	2020-04-22 10:11:09
Stakeholder analysis	Documents, reports	2020-04-22 10:11:10

Take a look to the deliverables list in detail: detailed list of ROBOX deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Gonzalo de Gonzalo, Maximilian FÃ¼rst, Marco Fraaije Polycyclic Ketone Monooxygenase (PockeMO): A Robust Biocatalyst for the Synthesis of Optically Active Sulfoxides published pages: 288, ISSN: 2073-4344, DOI: 10.3390/catal7100288	Catalysts 7/12	2020-04-22
2017	Friso S. Aalbers, Marco W. Fraaije Coupled reactions by coupled enzymes: alcohol to lactone cascade with alcohol dehydrogenaseâ€“cyclohexanone monooxygenase fusions published pages: 7557-7565, ISSN: 0175-7598, DOI: 10.1007/s00253-017-8501-4	Applied Microbiology and Biotechnology 101/20	2020-04-22
2017	Guangyue Li, Maximilian J. L. J. FÃ¼rst, Hamid Reza Mansouri, Anna K. Ressmann, Adriana Ilie, Florian Rudroff, Marko D. Mihovilovic, Marco W. Fraaije, Manfred T. Reetz Manipulating the stereoselectivity of the thermostable Baeyerâ€“Villiger monooxygenase TmCHMO by directed evolution published pages: 9824-9829, ISSN: 1477-0520, DOI: 10.1039/C7OB02692G	Organic & Biomolecular Chemistry 15/46	2020-04-22
2017	Iwona Kaluzna, Jan Brummund, and Martin Schuermann Production of diclofenac metabolites by applying cytochrome P450 technology published pages: 55-58, ISSN: 0392-839X, DOI:	Chimica Oggi - Chemistry Today vol. 35(6) November/December 20	2020-04-22
2018	Marie A. F. Delgove, Matthew T. Elford, Katrien V. Bernaerts, Stefaan M.A. De Wildeman Application of a thermostable Baeyer-Villiger monooxygenase for the synthesis of branched polyester precursors published pages: , ISSN: 0268-2575, DOI: 10.1002/jctb.5623	Journal of Chemical Technology & Biotechnology	2020-04-22
2017	Marie A. F. Delgove, Maximilian J. L. J. FÃ¼rst, Marco W. Fraaije, Katrien V. Bernaerts, Stefaan M. A. Deâ€…Wildeman Exploring the Substrate Scope of Baeyer-Villiger Monooxygenases with Branched Lactones as Entry towards Polyesters published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201700427	ChemBioChem	2020-04-22
2018	Astrid Weninger, Jasmin E. Fischer, Hana RaschmanovÃ¡, Claudia Kniely, Thomas Vogl, Anton Glieder Expanding the CRISPR/Cas9 toolkit for Pichia pastoris with efficient donor integration and alternative resistance markers published pages: 3183-3198, ISSN: 0730-2312, DOI: 10.1002/jcb.26474	Journal of Cellular Biochemistry 119/4	2020-04-22
2019	Jordi SolÃ©, Gloria Caminal, Martin SchÃ¼rmann, Gregorio Ãlvaro, Marina GuillÃ©n Co-immobilization of P450 BM3 and glucose dehydrogenase on different supports for application as a self-sufficient oxidative biocatalyst published pages: 244-255, ISSN: 0268-2575, DOI: 10.1002/jctb.5770	Journal of Chemical Technology & Biotechnology 94/1	2020-04-22
2017	Nguyen, Quoc-Thai Flavoenzymes at the crossroads of biocatalysis and structural biology published pages: , ISSN: , DOI:	1	2020-04-22
2018	Joanne L. Porter, Selina Sabatini, Jack Manning, Michele Tavanti, James L. Galman, Nicholas J. Turner, Sabine L. Flitsch Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope published pages: 1-8, ISSN: 0141-0229, DOI: 10.1016/j.enzmictec.2018.02.005	Enzyme and Microbial Technology 113	2020-04-22
2017	Michele Tavanti, Juan Mangas-Sanchez, Sarah L. Montgomery, Matthew P. Thompson, Nicholas J. Turner A biocatalytic cascade for the amination of unfunctionalised cycloalkanes published pages: 9790-9793, ISSN: 1477-0520, DOI: 10.1039/c7ob02569f	Organic & Biomolecular Chemistry 15/46	2020-04-22
2018	Joanne L. Porter, Jack Manning, Selina Sabatini, Michele Tavanti, Nicholas J. Turner, Sabine L. Flitsch Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus : P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids published pages: 513-520, ISSN: 1439-4227, DOI: 10.1002/cbic.201700598	ChemBioChem 19/5	2020-04-22
2018	Alexandra M. Weingartner, Daniel F. Sauer, Gaurao V. Dhoke, Mehdi D. Davari, Anna JoÃ«lle Ruff, Ulrich Schwaneberg A hydroquinone-specific screening system for directed P450 evolution published pages: 9657-9667, ISSN: 0175-7598, DOI: 10.1007/s00253-018-9328-3	Applied Microbiology and Biotechnology 102/22	2020-04-22
2018	Murray P. Meissner, Mathias Nordblad, John M. Woodley Online Measurement of Oxygen-Dependent Enzyme Reaction Kinetics published pages: 106-113, ISSN: 1439-4227, DOI: 10.1002/cbic.201700577	ChemBioChem 19/1	2020-04-22
2018	Quoc-Thai Nguyen, Elvira Romero, Willem P. Dijkman, Suzan Pantaroto de Vasconcellos, Claudia Binda, Andrea Mattevi, Marco W. Fraaije Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol published pages: 6209-6218, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.8b00918	Biochemistry 57/43	2020-04-22
2019	Ãngela Mourelle-Insua, Friso S. Aalbers, IvÃ¡n Lavandera, Vicente Gotor-FernÃ¡ndez, Marco W. Fraaije What to sacrifice? Fusions of cofactor regenerating enzymes with Baeyer-Villiger monooxygenases and alcohol dehydrogenases for self-sufficient redox biocatalysis published pages: 1832-1839, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.02.015	Tetrahedron 75/13	2020-04-22
2018	Marie A. F. Delgove, Matthew T. Elford, Katrien V. Bernaerts, Stefaan M. A. De Wildeman Toward Upscaled Biocatalytic Preparation of Lactone Building Blocks for Polymer Applications published pages: 803-812, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.8b00079	Organic Process Research & Development 22/7	2020-04-22
2019	Friso S. Aalbers, Marco W. Fraaije Design of Artificial Alcohol Oxidases: Alcohol Dehydrogenase-NADPH Oxidase Fusions for Continuous Oxidations published pages: 51-56, ISSN: 1439-4227, DOI: 10.1002/cbic.201800421	ChemBioChem 20/1	2020-04-22
2019	Friso S. Aalbers, Marco W. Fraaije Enzyme Fusions in Biocatalysis: Coupling Reactions by Pairing Enzymes published pages: 20-28, ISSN: 1439-4227, DOI: 10.1002/cbic.201800394	ChemBioChem 20/1	2020-04-22
2018	Mathias Nordblad, Mafalda Dias Gomes, Murray P. Meissner, Hemalata Ramesh, John M. Woodley Scoping Biocatalyst Performance Using Reaction Trajectory Analysis published pages: 1101-1114, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.8b00119	Organic Process Research & Development 22/9	2020-04-22
2018	Guangyue Li, Marc Garcia-BorrÃ s, Maximilian J. L. J. FÃ¼rst, Adriana Ilie, Marco W. Fraaije, K. N. Houk, Manfred T. Reetz Overriding Traditional Electronic Effects in Biocatalytic Baeyerâ€“Villiger Reactions by Directed Evolution published pages: 10464-10472, ISSN: 0002-7863, DOI: 10.1021/jacs.8b04742	Journal of the American Chemical Society 140/33	2020-04-22
2018	Marie A.F. Delgove, Daniela Valencia, Jordi SolÃ©, Katrien V. Bernaerts, Stefaan M.A. De Wildeman, Marina GuillÃ©n, Gregorio Ãlvaro High performing immobilized Baeyer-Villiger monooxygenase and glucose dehydrogenase for the synthesis of Æ-caprolactone derivative published pages: 134-141, ISSN: 0926-860X, DOI: 10.1016/j.apcata.2018.12.036	Applied Catalysis A: General 572	2020-04-22
2019	Marie A. F. Delgove, Achille-B. Laurent, John M. Woodley, Stefaan M. A. De Wildeman, Katrien V. Bernaerts, Yvonne van der Meer A prospective life-cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry published pages: , ISSN: 1864-5631, DOI: 10.1002/cssc.201900007	ChemSusChem	2020-04-22
2017	Michele Tavanti, Fabio Parmeggiani, Jose RubÃ©n GÃ³mez Castellanos, Andrea Mattevi, Nicholas John Turner One-pot Biocatalytic Double Oxidation of Î±-Isophorone for the Synthesis of Ketoisophorone published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201700620	ChemCatChem	2020-04-22
2017	Marie A. F. Delgove, JuandrÃ© Luchies, Iris Wauters, Geert G. P. Deroover, Stefaan M. A. De Wildeman, Katrien V. Bernaerts Increasing the solubility range of polyesters by tuning their microstructure with comonomers published pages: , ISSN: 1759-9954, DOI: 10.1039/C7PY00976C	Polym. Chem.	2020-04-22
2017	Maximilian J. L. J. FÃ¼rst, Simone Savino, Hanna M. Dudek, J. RÃºben GÃ³mez Castellanos, Cora GutiÃ©rrez de Souza, Stefano Rovida, Marco W. Fraaije, Andrea Mattevi Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila : A Structurally Distinct Biocatalyst for Bulky Substrates published pages: 627-630, ISSN: 0002-7863, DOI: 10.1021/jacs.6b12246	Journal of the American Chemical Society 139/2	2020-04-22
2016	Quoc-Thai Nguyen, Gonzalo deâ€…Gonzalo, Claudia Binda, Ana Rioz-MartÃnez, Andrea Mattevi, Marco W. Fraaije Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst published pages: 1359-1366, ISSN: 1439-4227, DOI: 10.1002/cbic.201600148	ChemBioChem 17/14	2020-04-22
2016	Elvira Romero, J. RubÃ©n GÃ³mez Castellanos, Andrea Mattevi, Marco W. Fraaije Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase published pages: 16084-16087, ISSN: 0044-8249, DOI: 10.1002/ange.201608951	Angewandte Chemie 128/51	2020-04-22

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