Explore the words cloud of the PRISM project. It provides you a very rough idea of what is the project "PRISM" about.
The following table provides information about the project.
Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | http://www.voetslab.nl |
Total cost | 1˙661˙605 € |
EC max contribution | 1˙661˙605 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-STG |
Funding Scheme | ERC-STG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-01 to 2020-04-30 |
Take a look of project's partnership.
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1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 1˙661˙605.00 |
Crystallization of water into ice is lethal to most organisms and detrimental to many soft materials. Freeze-tolerant fish living in polar seas evolved to tackle this problem with an unusual coping strategy. They produce ‘antifreeze’ proteins that block the growth of nascent ice crystals within a narrow temperature range known as the ‘thermal hysteresis gap’ enabling survival under extreme conditions. Encoding this functionality into synthetic polymers would open up new avenues in biomedicine, agrifood and materials science for e.g. cryopreservation, crop hardiness, ice-templating, dispersion stability, and advanced coatings. Progress requires a profound understanding of the mechanism of non-colligative freezing point depression at the molecular level and allows for efficient strategies for the design and preparation of powerful macromolecular antifreezes.
I propose to unravel how antifreeze proteins work and to build upon these insights to explore effective routes towards ice-binding polymers aiming to make sensitive soft materials freeze-resistant. Within this challenge we first focus on single-molecule experiments to visualize bound proteins and study the strength of the non-covalent interaction with ice. We will study if and when adsorption on ‘foreign’ interfaces and solution assembly impact activity. These fundamental insights will guide our research towards synthetic antifreeze agents with superior functionality to achieve record supercooling in complex environments. This knowledge-based design of polymers with high affinity for crystalline interfaces holds great promise for many areas of science and technology in which crystallization plays a decisive role.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Christian C. M. Sproncken, Romà SurÃs-Valls, Hande E. Cingil, Christophe Detrembleur, Ilja K. Voets Complex Coacervate Core Micelles Containing Poly(vinyl alcohol) Inhibit Ice Recrystallization published pages: 1700814, ISSN: 1022-1336, DOI: 10.1002/marc.201700814 |
Macromolecular Rapid Communications 39/17 | 2020-04-22 |
2017 |
Anneloes S. Oude Vrielink, Tyler D. R. Vance, Arthur M. de Jong, Peter L. Davies, Ilja K. Voets Unusually high mechanical stability of bacterial adhesin extender domains having calcium clamps published pages: e0174682, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0174682 |
PLOS ONE 12/4 | 2020-04-22 |
2018 |
Z. Faidon Brotzakis, Ilja K. Voets, Huib J. Bakker, Peter G. Bolhuis Water structure and dynamics in the hydration layer of a type III anti-freeze protein published pages: 6996-7006, ISSN: 1463-9076, DOI: 10.1039/c8cp00170g |
Physical Chemistry Chemical Physics 20/10 | 2020-04-22 |
2017 |
Qing Ke, Yong-Yeol Ahn, Cassidy R. Sugimoto A systematic identification and analysis of scientists on Twitter published pages: e0175368, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0175368 |
PLOS ONE 12/4 | 2020-04-22 |
2017 |
I. K. Voets From ice-binding proteins to bio-inspired antifreeze materials published pages: 4808-4823, ISSN: 1744-683X, DOI: 10.1039/C6SM02867E |
Soft Matter 13/28 | 2020-04-22 |
2016 |
Anneloes S. Oude Vrielink, Antonio Aloi, Luuk L. C. Olijve, Ilja K. Voets Interaction of ice binding proteins with ice, water and ions published pages: 18906, ISSN: 1559-4106, DOI: 10.1116/1.4939462 |
Biointerphases 11/1 | 2020-04-22 |
2017 |
Z. Faidon Brotzakis, Mascha Gehre, Ilja K. Voets, Peter G. Bolhuis Stability and growth mechanism of self-assembling putative antifreeze cyclic peptides published pages: 19032-19042, ISSN: 1463-9076, DOI: 10.1039/C7CP02465G |
Physical Chemistry Chemical Physics 19/29 | 2020-04-22 |
2016 |
Luuk L. C. Olijve, Konrad Meister, Arthur L. DeVries, John G. Duman, Shuaiqi Guo, Huib J. Bakker, Ilja K. Voets Blocking rapid ice crystal growth through nonbasal plane adsorption of antifreeze proteins published pages: 3740-3745, ISSN: 0027-8424, DOI: 10.1073/pnas.1524109113 |
Proceedings of the National Academy of Sciences 113/14 | 2020-04-22 |
2017 |
Shuaiqi Guo, Corey A. Stevens, Tyler D. R. Vance, Luuk L. C. Olijve, Laurie A. Graham, Robert L. Campbell, Saeed R. Yazdi, Carlos Escobedo, Maya Bar-Dolev, Victor Yashunsky, Ido Braslavsky, David N. Langelaan, Steven P. Smith, John S. Allingham, Ilja K. Voets, Peter L. Davies Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice published pages: e1701440, ISSN: 2375-2548, DOI: 10.1126/sciadv.1701440 |
Science Advances 3/8 | 2020-04-22 |
2016 |
Luuk L. C. Olijve, Anneloes S. Oude Vrielink, Ilja K. Voets A Simple and Quantitative Method to Evaluate Ice Recrystallization Kinetics Using the Circle Hough Transform Algorithm published pages: 4190-4195, ISSN: 1528-7483, DOI: 10.1021/acs.cgd.5b01637 |
Crystal Growth & Design 16/8 | 2020-04-22 |
2016 |
Luuk L. C. Olijve, Marco M. R. M. Hendrix, Ilja K. Voets Influence of Polymer Chain Architecture of Poly(vinyl alcohol) on the Inhibition of Ice Recrystallization published pages: 951-958, ISSN: 1022-1352, DOI: 10.1002/macp.201500497 |
Macromolecular Chemistry and Physics 217/8 | 2020-04-22 |
2016 |
Antonio Aloi, Clément Guibert, Luuk L.C. Olijve, Ilja K. Voets Morphological evolution of complex coacervate core micelles revealed by iPAINT microscopy published pages: 450-455, ISSN: 0032-3861, DOI: 10.1016/j.polymer.2016.08.002 |
Polymer 107 | 2020-04-22 |
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