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ONCORNET SIGNED

ONCOgenic Receptor Network of Excellence and Training

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ONCORNET project word cloud

Explore the words cloud of the ONCORNET project. It provides you a very rough idea of what is the project "ONCORNET" about.

purposes skills receptor therapeutic entrepreneurship media small operate cxcr4 diagnostic modulated underlying protein rarely drugs fundamental chemokine writing scientists receptors employ molecules imaging cancer esrs transferable tools oncogenic extensive signalling metastasis amenable latest excellence proteomics labs industries health 15 tumours drug ideal employers commercialisation understand technologies multidisciplinary phd unravelling oncornet expressed manipulation training gpcrs extrapolated train progression discovery cascades nanodies skill stage network leads generation demanded pepducins cxcr7 coupled

Project "ONCORNET" data sheet

The following table provides information about the project.

Coordinator	STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.oncornet.eu
Total cost	3˙893˙983 €
EC max contribution	3˙893˙983 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	510˙748.00
2	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	546˙575.00
3	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	546˙575.00
4	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	525˙751.00
5	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	512˙091.00
6	JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Organization address address: SANDERRING 2 city: WUERZBURG postcode: 97070 website: http://www.uni-wuerzburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WUERZBURG)	participant	498˙432.00
7	GRIFFIN DISCOVERIES BV GRIFFIN DISCOVERIES BV Organization address address: DE BOEDELAAN 1083 city: AMSTERDAM postcode: 1081HV website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
8	ARGEN-X ARGEN-X Organization address address: TECHNOLOGIEPARK 30 city: ZWIJNAARDE postcode: B-9052 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE)	participant	250˙560.00
9	UNIVERSIDAD AUTONOMA DE MADRID UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO city: MADRID postcode: 28049 website: http://www.uam.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
10	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	0.00
11	24 Media Labs 24 Media Labs Organization address address: Vasteland 78 city: Rotterdam postcode: 3011 BN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Rotterdam)	partner	0.00
12	ACTELION PHARMACEUTICALS LTD ACTELION PHARMACEUTICALS LTD Organization address address: GEWERBESTRASSE 16 city: ALLSCHWIL postcode: 4123 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ALLSCHWIL)	partner	0.00
13	ALMAC SCIENCES LIMITED ALMAC SCIENCES LIMITED Organization address address: ALMAC HOUSE - SEAGOE INDUSTRIAL ESTATE 20 city: CRAIGAVON postcode: BT63 5QD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CRAIGAVON)	partner	0.00
14	Cisbio Bioassays Cisbio Bioassays Organization address address: PARC MARCEL BOITEUX city: CODOLET postcode: 30200 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CODOLET)	partner	0.00
15	Euroscreen S.A. Euroscreen S.A. Organization address address: Rue Adrienne Bolland city: Gosselies postcode: 6041 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Gosselies)	partner	0.00
16	Vivia Biosystmes S.L. Vivia Biosystmes S.L. Organization address address: MENENDEZ PELAYO ST 12 city: VALLADOLID postcode: 47001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALLADOLID)	partner	0.00

Map

Project objective

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.

Deliverables

List of deliverables.
Open meetings organized	Other	2020-04-01 17:55:45
Output	Websites, patent fillings, videos etc.	2020-04-01 17:55:45
Supervisory board of Network	Other	2020-04-01 17:55:44
Mid-Term Review meeting	Documents, reports	2020-04-01 17:55:44
Progress Report	Documents, reports	2020-04-01 17:55:43
Draft Periodic Report	Documents, reports	2020-04-01 17:55:44
Ethics	Documents, reports	2020-04-01 17:55:44
ONCORNET website	Websites, patent fillings, videos etc.	2020-04-01 17:55:43

Take a look to the deliverables list in detail: detailed list of ONCORNET deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf, Carmen Gallego Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system. published pages: mol.118.115329, ISSN: 0026-895X, DOI: 10.1124/mol.118.115329	Molecular Pharmacology	2020-04-01
2016	Bas van der Woning, Gitte De Boeck, Christophe Blanchetot, Vladimir Bobkov, Alex Klarenbeek, Michael Saunders, Magali Waelbroeck, Toon Laeremans, Jan Steyaert, Anna Hultberg, Hans De Haard DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops published pages: 1126-1135, ISSN: 1942-0870, DOI: 10.1080/19420862.2016.1189050	mAbs 8/6	2020-04-01
2017	Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding published pages: , ISSN: , DOI: 10.1007/7355_2017_2	Topics in Medicinal Chemistry	2020-04-01
2017	Laura NoguÃ©s, Clara Reglero, VerÃ³nica Rivas, MarÃa Neves, Petronila Penela, Federico Mayor G-Proteinâ€“Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer published pages: 220-228, ISSN: 0026-895X, DOI: 10.1124/mol.116.107185	Molecular Pharmacology 91/3	2020-04-01
2019	Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor The role of ACKR3 in breast, lung and brain cancer. published pages: mol.118.115279, ISSN: 0026-895X, DOI: 10.1124/mol.118.115279	Molecular Pharmacology	2020-04-01
2018	Vladimir Bobkov, Aurelien M. Zarca, Anneleen Van Hout, Marta Arimont, Jordi Doijen, Magdalena Bialkowska, Elisa Toffoli, Alex Klarenbeek, Bas van der Woning, Hans J. van der Vliet, Tom Van Loy, Hans de Haard, Dominique Schols, Raimond Heukers, Martine J. Smit Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions published pages: 413-424, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.10.014	Biochemical Pharmacology 158	2020-04-01
2018	Anneleen Van Hout, Alex Klarenbeek, Vladimir Bobkov, Jordi Doijen, Marta Arimont, Chunxia Zhao, Raimond Heukers, Rebecca Rimkunas, Chris de Graaf, Theo Verrips, Bas van der Woning, Hans de Haard, Joseph B. Rucker, Kurt Vermeire, Tracy Handel, Tom Van Loy, Martine J. Smit, Dominique Schols CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry published pages: 402-412, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.10.015	Biochemical Pharmacology 158	2020-04-01
2018	Laura NoguÃ©s, Julia Palacios-GarcÃa, Clara Reglero, VerÃ³nica Rivas, MarÃa Neves, Catalina Ribas, Petronila Penela, Federico Mayor G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs published pages: 78-90, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2017.04.013	Seminars in Cancer Biology 48	2020-04-01
2019	I. Adlere, S. Sun, A. Zarca, L. Roumen, M. Gozelle, C. PerpiÃ±Ã¡ Viciano, B. Caspar, M. Arimont, J.P. Bebelman, S.J. Briddon, C. Hoffmann, S.J. Hill, M.J. Smit, H.F. Vischer, M. Wijtmans, C. de Graaf, I.J.P. de Esch, R. Leurs Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists published pages: 631-649, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.10.060	European Journal of Medicinal Chemistry 162	2020-04-01
2017	Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, FranÃ§oise Bachelerie, Martine J. Smit CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome published pages: 35-44, ISSN: 0022-3565, DOI: 10.1124/jpet.117.242735	Journal of Pharmacology and Experimental Therapeutics 363/1	2020-04-01
2017	Marta Arimont, Shan-Liang Sun, Rob Leurs, Martine Smit, Iwan J. P. de Esch, Chris de Graaf Structural Analysis of Chemokine Receptorâ€“Ligand Interactions published pages: 4735-4779, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01309	Journal of Medicinal Chemistry 60/12	2020-04-01
2017	Beatrice Oehler, Milad Mohammadi, Cristina Perpina Viciano, Dagmar Hackel, Carsten Hoffmann, Alexander Brack, Heike L. Rittner Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00242	Frontiers in Molecular Neuroscience 10	2020-04-01
2017	NikaÃ¯a Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, BÃ©nÃ©dicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, FranÃ§oise Bachelerie, Olivier Schwartz, Jan MÃ¼nch, Andreas Wack, SÃ©bastien Nisole, Jean-Philippe Herbeuval Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms14253	Nature Communications 8/1	2020-04-01
2019	Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit, Philippe Marin CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status published pages: mol.118.115360, ISSN: 0026-895X, DOI: 10.1124/mol.118.115360	Molecular Pharmacology	2020-04-01
2016	Laura NoguÃ©s, Clara Reglero, VerÃ³nica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto BerjÃ³n, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Petronila Penela G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis published pages: 132-145, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2016.09.030	EBioMedicine 13	2020-04-01
2019	Timo W.M. De Groof, Vladimir Bobkov, Raimond Heukers, Martine J. Smit Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs published pages: 15-24, ISSN: 0303-7207, DOI: 10.1016/j.mce.2019.01.021	Molecular and Cellular Endocrinology 484	2020-04-01

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