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SCIENCE SIGNED

Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SCIENCE project word cloud

Explore the words cloud of the SCIENCE project. It provides you a very rough idea of what is the project "SCIENCE" about.

options society women rationalising option practise nature expects caused stromal patients medium morbidity conventional companies stem left realistic million burden therapies myocardial therapy translational adipose feasibility industry treatment platform approval trial implementati consolidation cardiac pave death conducting countries clinical care national medicine small significantly chronic allogeneic admissions function cells multicentre 2012 biomedical form ihd close disease deaths ease rate science worldwide ageing treatable industrialised scientists 47 mortality men six simplifying constituting 17 hospital standard cell heart huge manufacturing size international artery innovative experts ischemic population coronary

Project "SCIENCE" data sheet

The following table provides information about the project.

Coordinator	REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://stemcellscience.dk/
Total cost	5˙998˙882 €
EC max contribution	5˙998˙882 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-single-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	coordinator	3˙309˙862.00
2	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	670˙625.00
3	CARDIOLOGICUM HAMBURG CARDIOLOGICUM HAMBURG Organization address address: SCHLOSSGARTEN 3 city: HAMBURG postcode: 22041 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	423˙750.00
4	UNIVERZITETNI KLINICNI CENTER LJUBLJANA UNIVERZITETNI KLINICNI CENTER LJUBLJANA Organization address address: ZALOSKA CESTA 002 city: LJUBLJANA postcode: 1000 website: http://www.kclj.si/nuklearna contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	423˙125.00
5	SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH Organization address address: UL. PONIATOWSKIEGO 15 city: KATOWICE postcode: 40 055 website: www.sum.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KATOWICE)	participant	416˙000.00
6	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	321˙875.00
7	TERUMO BCT EUROPE NV TERUMO BCT EUROPE NV Organization address address: IKAROSLAAN 41 city: ZAVENTEM postcode: 1930 website: www.terumobct.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZAVENTEM)	participant	232˙083.00
8	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	143˙750.00
9	WILLIAM COOK EUROPE ApS WILLIAM COOK EUROPE ApS Organization address address: SANDET 6 city: BJAEVERSKOV postcode: 4632 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BJAEVERSKOV)	participant	57˙812.00

Map

Project objective

Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)

With more than 17 million deaths worldwide each year, ischemic heart disease (IHD) caused by coronary artery disease is the most common cause of death and a major cause of hospital admissions in industrialised countries. IHD caused over four million deaths in Europe in the year 2012 constituting 47% of all deaths. Today IHD is the main cause of death among women throughout Europe and the main cause of death among men in all but six European countries.

Conventional therapies have reduced mortality of IHD significantly, but have left an increasing number of patients with chronic IHD and/or heart failure without further treatment options. An increasing morbidity rate of this nature in an ageing population is a huge burden for society.

The overall aim of the SCIENCE project is to implement an effective stem cell-based therapy with allogeneic adipose derived stromal cells to improve myocardial function in patients with ischemic heart disease and heart failure. This goal will be achieved by conducting a multicentre clinical trial in a strong consortium of experienced international scientists and experts as well as significant representatives of the biomedical industry within translational medicine and a close collaboration with relevant authorities.

The consortium will ensure feasibility of treatment by simplifying and rationalising cell production and distribution using state-of-the art manufacturing technology that makes cell therapy a realistic option for clinical practise. The consortium expects the SCIENCE project to pave the way for future approval of this treatment by national authorities throughout Europe as the standard form of care for patients with ischemic heart disease and heart failure.

This concept will establish a new platform for growth and consolidation of innovative small and medium-size companies within stem cell research and development. Such a platform will ease implementati

Deliverables

List of deliverables.
IMP production final	Other	2020-04-07 19:25:52
Clinical databases	Demonstrators, pilots, prototypes	2020-04-07 19:25:51
First patient treated	Other	2020-04-07 19:25:51
Training logs	Documents, reports	2020-04-07 19:25:51
Website	Websites, patent fillings, videos etc.	2020-04-07 19:25:51
Clinical trial kick-off	Other	2020-04-07 19:25:51
All approvals package	Documents, reports	2020-04-07 19:25:51
Production initiated	Demonstrators, pilots, prototypes	2020-04-07 19:25:51
Preliminary cost-effectiveness analysis	Documents, reports	2020-04-07 19:25:51
Qualification of production facility	Documents, reports	2020-04-07 19:25:51

Take a look to the deliverables list in detail: detailed list of SCIENCE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Francisco FernÃ¡ndez-AvilÃ©s, Ricardo Sanz-Ruiz, Andreu M. Climent, Lina Badimon, Roberto Bolli, Dominique Charron, Valentin Fuster, Stefan Janssens, Jens Kastrup, Hyo-Soo Kim, Thomas F. LÃ¼scher, John F. Martin, Philippe MenaschÃ©, Fausto J. Pinto, Robert D. Simari, Gregg W. Stone, Andre Terzic, James T. Willerson, Joseph C. Wu Global Overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Recommendations published pages: 199-201, ISSN: 0009-7330, DOI: 10.1161/circresaha.117.312099	Circulation Research 122/2	2020-04-07
2019	Christina Paitazoglou, Martin W. Bergmann, Bojan Vrtovec, Steven A.J. Chamuleau, Bas van Klarenbosch, Wojtek Wojakowski, Aleksandra Michalewska-WÅ‚udarczyk, Mariann GyÃ¶ngyÃ¶si, Annette Ekblond, Mandana Haack-SÃ¸rensen, Kai Jaquet, Karsten Vrangbaek, Jens Kastrup Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE) published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1412	European Journal of Heart Failure	2020-04-07
2018	Mandana Haack-SÃ¸rensen, Morten Juhl, Bjarke Follin, Rebekka Harary SÃ¸ndergaard, Maria Kirchhoff, Jens Kastrup, Annette Ekblond Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate published pages: 293-300, ISSN: 0036-5513, DOI: 10.1080/00365513.2018.1462082	Scandinavian Journal of Clinical and Laboratory Investigation 78/4	2020-04-07
2016	Mariann GyÃ¶ngyÃ¶si, Wojciech Wojakowski, Eliano P. Navarese, Lemuel Ã€. Moye Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies published pages: 1254-1263, ISSN: 0009-7330, DOI: 10.1161/circresaha.115.307347	Circulation Research 118/8	2020-04-07
2017	Abbas Ali Qayyum, Kamal Preet Kaur, Anders Bruun Mathiasen, Mandana Haack-SÃ¸rensen, Annette Ekblond, Jens Kastrup Influence of patient related factors on number of mesenchymal stromal cells reached after in vitro culture expansion for clinical treatment published pages: 541-548, ISSN: 0036-5513, DOI: 10.1080/00365513.2017.1354258	Scandinavian Journal of Clinical and Laboratory Investigation 77/7	2020-04-07
2017	Francisco FernÃ¡ndez-AvilÃ©s, Ricardo Sanz-Ruiz, Andreu M. Climent, Lina Badimon, Roberto Bolli, Dominique Charron, Valentin Fuster, Stefan Janssens, Jens Kastrup, Hyo-Soo Kim, Thomas F. LÃ¼scher, John F. Martin, Philippe MenaschÃ©, Robert D. Simari, Gregg W. Stone, Andre Terzic, James T. Willerson, Joseph C. Wu, Francisco FernÃ¡ndez-AvilÃ©s, Andre Terzic, Lina Badimon, Kathleen Broughton, Darcy L Global position paper on cardiovascular regenerative medicine published pages: 2532-2546, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx248	European Heart Journal 38/33	2020-04-07
2017	Jozef Bartunek, Wojtek Wojakowski Intracoronary autologous bone marrow cell transfer after acute myocardial infarction: abort and refocus published pages: 2944-2947, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx300	European Heart Journal 38/39	2020-04-07
2017	Jens Kastrup, Morten Schou, Ida Gustafsson, Olav W. Nielsen, Rasmus MÃ¸gelvang, Klaus F. Kofoed, Charlotte Kragelund, Jens Dahlgaard Hove, Andreas Fabricius-Bjerre, Merete Heitman, Mandana Haack-SÃ¸rensen, Lisbeth Drozd Lund, Ellen MÃ¸nsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Annette Ekblond Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study published pages: 1-8, ISSN: 1687-966X, DOI: 10.1155/2017/8506370	Stem Cells International 2017	2020-04-07
2016	Mariusz Z. Ratajczak, Kamila Bujko, Wojciech Wojakowski Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies published pages: 879-890, ISSN: 1897-9483, DOI: 10.20452/pamw.3644	Polish Archives of Internal Medicine 126/11	2020-04-07
2017	Jens Kastrup, Mandana Haack-SÃ¸rensen, Morten Juhl, Rebekka Harary SÃ¸ndergaard, Bjarke Follin, Lisbeth Drozd Lund, Ellen MÃ¸nsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Erik JÃ¸rgensen, Steffen Helqvist, Jens JÃ¸rgen Elberg, Helle Bruunsgaard, Annette Ekblond Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure-A Safety Study published pages: 1963-1971, ISSN: 2157-6564, DOI: 10.1002/sctm.17-0040	STEM CELLS Translational Medicine 6/11	2020-04-07

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