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CRYDIS

Driving innovation in pharmaceuticals: integrated studies of physical dissolution properties of crystalline and amorphous forms using enhanced orthogonal monitoring techniques

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CRYDIS project word cloud

Explore the words cloud of the CRYDIS project. It provides you a very rough idea of what is the project "CRYDIS" about.

expertise networks transfer undertakes media transferring outreach sufficient utility drug struggles patient subsequent absorption soluble sectoral poorly industrial nucleation substance applicable offers precipitation imaging additional technologies pharmaceutical re running exchange shared substances science assays data synergistic particles collaborative capability breakthroughs institutes clinically uv outcomes prior leveraging instrument inter protocols undesired mechanisms crydis parallel international advise companies effectiveness bio investigates fundamental dose innovative drive absorbed market tools exposure materials close dissolution building innovation culture obtain mechanism input kinetics industry

Project "CRYDIS" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	https://pharmacy.ku.dk/research/pharmaceutical-physical-analytical-chemistry/crydis/
Total cost	216˙000 €
EC max contribution	216˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	130˙500.00
2	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	31˙500.00
3	PFIZER LIMITED PFIZER LIMITED Organization address address: RAMSGATE ROAD city: SANDWICH postcode: CT13 9NJ website: www.pfizer.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SANDWICH)	participant	27˙000.00
4	PARAYTEC LIMITED PARAYTEC LIMITED Organization address address: YORK HOUSE OUTGANG LANE OSBALDWICK city: YORK postcode: YO19 5UP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK)	participant	18˙000.00
5	PION INC.(UK) LTD PION INC.(UK) LTD Organization address address: RIVERSIDE FOREST ROW BUSINESS PARK city: FOREST ROW postcode: RH18 5DW website: www.sirius-analytical.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (FOREST ROW)	participant	9˙000.00

Map

Project objective

The CRYDIS exchange programme will establish and support international and inter-sectoral transfer of knowledge and expertise in pharmaceutical and instrument science between several EU research institutes and industrial companies. It will also enhance understanding of the value of inter-sectoral exchange mechanisms for taking research to market. CRYDIS undertakes innovative, collaborative research on the clinically-important topic of dissolution of drug substance particles in bio-relevant media and the undesired subsequent nucleation and re-precipitation of the drug prior to its absorption. Using innovative advances in UV imaging technology, CRYDIS investigates the utility of novel dissolution assays as key tools to obtain fundamental data on the mechanism and kinetics of undesired nucleation and re-precipitation during or following dissolution, a significant problem for the pharmaceutical industry which struggles to obtain sufficient exposure to poorly soluble drug substances to ensure an effective dose is absorbed by the patient. The key technologies in this proposal offer a step change in capability and functionality, offering the potential to undertake more detailed studies of the dissolution/re-precipitation processes relevant to pharmaceutical materials. Access to this key technology and the further development of its capability offers the potential for breakthroughs in development of process understanding and of robust and widely applicable protocols. Additional value is brought to CRYDIS through close working with synergistic European networks, leveraging a greater knowledge input and impact outreach. Running parallel with the science programme, an innovation management work-package analyses effectiveness of the exchange mechanism in building a shared culture, transferring knowledge and developing understanding of processes that drive a product to market. The outcomes of this will be used to advise and drive potential future exchange activities.

Deliverables

List of deliverables.
Technical note on new capabilities	Documents, reports	2019-10-28 17:20:03
Literature publications for D2.1-D2.4	Documents, reports	2019-10-28 17:20:03
Operating parameters for imaging & variability	Demonstrators, pilots, prototypes	2019-10-28 17:20:03
Technical data on nucleation rates	Documents, reports	2019-10-28 17:20:03
Screening assay for precipitation inhibitors	Demonstrators, pilots, prototypes	2019-10-28 17:20:03
Dissolution testing guidelines for UV/Raman	Documents, reports	2019-10-28 17:20:03
Literature publications for D3.1 & D3.2	Documents, reports	2019-10-28 17:20:03
ATR-(FTIR) & turbidity studies	Demonstrators, pilots, prototypes	2019-10-28 17:20:02
pH-UV imaging method	Demonstrators, pilots, prototypes	2019-10-28 17:20:02
UV imaging data validation	Demonstrators, pilots, prototypes	2019-10-28 17:20:02
Technical report on approaches to SDI	Documents, reports	2019-10-28 17:20:02
Optimised UV/Raman experiments	Demonstrators, pilots, prototypes	2019-10-28 17:20:02
Prototype light microscopy â€“ UV imaging assay	Demonstrators, pilots, prototypes	2019-10-28 17:20:02
Technical report on new capabilities	Documents, reports	2019-10-28 17:20:02

Take a look to the deliverables list in detail: detailed list of CRYDIS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Peter Madelung, Poul Bertelsen, Jette Jacobsen, Anette MÃ¼llertz, Jesper Ã˜stergaard Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging published pages: 516-522, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2017.05.010	Journal of Drug Delivery Science and Technology 39	2019-10-28
2018	Maria Doreth, Korbinian LÃ¶bmann, Petra Priemel, Holger Grohganz, Robert Taylor, RenÃ© Holm, Heidi Lopez de Diego, Thomas Rades Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin published pages: 62-69, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2017.10.001	European Journal of Pharmaceutics and Biopharmaceutics 122	2019-10-28
2018	Jesper Ã˜stergaard UV imaging in pharmaceutical analysis published pages: 140-148, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2017.07.055	Journal of Pharmaceutical and Biomedical Analysis 147	2019-10-28
2016	Sabrine S. Jensen, Henrik Jensen, David M. Goodall, Jesper Ã˜stergaard Performance characteristics of UV imaging instrumentation for diffusion, dissolution and release testing studies published pages: 113-123, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2016.08.018	Journal of Pharmaceutical and Biomedical Analysis 131	2019-10-28
2017	Yu Sun, Jesper Ã˜stergaard Application of UV Imaging in Formulation Development published pages: 929-940, ISSN: 0724-8741, DOI: 10.1007/s11095-016-2047-5	Pharmaceutical Research 34/5	2019-10-28

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The information about "CRYDIS" are provided by the European Opendata Portal: CORDIS opendata.