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AEGLE

AEGLE (Ancient Greek: Αá¼´γλη) – An analytics framework for integrated and personalized healthcare services in Europe

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AEGLE project word cloud

Explore the words cloud of the AEGLE project. It provides you a very rough idea of what is the project "AEGLE" about.

time innovative lingual molecular techniques estimators combination multidimensional clinical chronic diseases fast algorithms analytics linear limited technologies allocation regulatory solutions ngs semantics realize ecosystem databases evolution systemic provision border extraction ict coming visualization computational informatics 3vs located acceleration speed medical cross computing estimation care versatility estimates communication big bio space biodata parametric volume dynamic found pca data velocity services landscape multiparametric analysing resource metrics led aegle hpc custom demands business health ehrs cloud coupled biostreams malignant quantified critical local modal handling bottlenecks medication stakeholders 3v solution decision infrastructures aggregated efficiency platform heterogeneous integration chain domain

Project "AEGLE" data sheet

The following table provides information about the project.

Coordinator	EXODUS ANONYMOS ETAIREIA PLIROFORIKIS Organization address address: ESTIAS 1 & MESOGEION 73-75 city: ATHINA postcode: 11526 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://www.aegle-uhealth.eu
Total cost	6˙079˙642 €
EC max contribution	5˙230˙698 € (86%)
Programme	1. H2020-EU.2.1.1.4. (Content technologies and information management: ICT for digital content, cultural and creative industries)
Code Call	H2020-ICT-2014-1
Funding Scheme	IA
Starting year	2015
Duration (year-month-day)	from 2015-03-01 to 2018-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EXODUS ANONYMOS ETAIREIA PLIROFORIKIS EXODUS ANONYMOS ETAIREIA PLIROFORIKIS Organization address address: ESTIAS 1 & MESOGEION 73-75 city: ATHINA postcode: 11526 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	coordinator	647˙500.00
2	ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS Organization address address: CHARILAOU THERMI ROAD 6 KM city: THERMI THESSALONIKI postcode: 57001 website: www.certh.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (THERMI THESSALONIKI)	participant	583˙125.00
3	INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS Organization address address: Patission Str. 42 city: ATHINA postcode: 10682 website: www.iccs.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	567˙437.00
4	MAXELER TECHNOLOGIES LIMITED MAXELER TECHNOLOGIES LIMITED Organization address address: 3 & 4 ALBION PLACE city: LONDON postcode: W6 0QT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	541˙187.00
5	KINGSTON UNIVERSITY HIGHER EDUCATION CORPORATION KINGSTON UNIVERSITY HIGHER EDUCATION CORPORATION Organization address address: RIVER HOUSE HIGH STREET 53-57 city: KINGSTON UPON THAMES postcode: KT1 1LQ website: http://www.kingston.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (KINGSTON UPON THAMES)	participant	493˙193.00
6	ERASMUS UNIVERSITEIT ROTTERDAM ERASMUS UNIVERSITEIT ROTTERDAM Organization address address: BURGEMEESTER OUDLAAN 50 city: ROTTERDAM postcode: 3062 PA website: www.eur.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	376˙250.00
7	CROYDON HEALTH SERVICES NATIONAL HEALTH SERVICE TRUST CROYDON HEALTH SERVICES NATIONAL HEALTH SERVICE TRUST Organization address address: LONDON ROAD 530 CROYDON UNIVERSITY HOSPITAL city: CROYDON SURREY postcode: CR7 7YE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CROYDON SURREY)	participant	355˙625.00
8	TIME.LEX TIME.LEX Organization address address: JOSEPH STEVENSSTRAAT 7 city: BRUSSEL postcode: 1000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSEL)	participant	329˙000.00
9	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	301˙250.00
10	MAAT FRANCE SARL MAAT FRANCE SARL Organization address address: IMPASSE DES PRES D EN BAS city: ARGONAY postcode: 74370 website: www.maatg.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ARGONAY)	participant	245˙481.00
11	THE NOTTINGHAM TRENT UNIVERSITY THE NOTTINGHAM TRENT UNIVERSITY Organization address address: 50 SHAKESPEARE STREET city: NOTTINGHAM postcode: NG1 4FQ website: www.ntu.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	224˙948.00
12	GLOBAZ, S.A. GLOBAZ, S.A. Organization address address: LARGO LUIS DE CAMOES EDIFICIO RAINHA PISO 12 city: OLIVEIRA DE AZEMEIS postcode: 3720 232 website: www.globazgrupo.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (OLIVEIRA DE AZEMEIS)	participant	217˙700.00
13	UNIVERSITA VITA-SALUTE SAN RAFFAELE UNIVERSITA VITA-SALUTE SAN RAFFAELE Organization address address: VIA OLGETTINA 58 city: MILANO postcode: 20132 website: www.unihsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	191˙250.00
14	PANEPISTIMIAKO GENIKO NOSOKOMEIO IRAKLEIOU PANEPISTIMIAKO GENIKO NOSOKOMEIO IRAKLEIOU Organization address address: VOUTES city: IRAKLEIO postcode: 71110 website: www.pagni.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	participant	156˙750.00

Map

Project objective

The data generated in the health domain is coming from heterogeneous, multi-modal, multi-lingual, dynamic and fast evolving medical technologies. Today we are found in a big health landscape characterized by large volume, versatility and velocity (3Vs) which has led to the evolution of the informatics in the big biodata domain. AEGLE project will build an innovative ICT solution addressing the whole data value chain for health based on: cloud computing enabling dynamic resource allocation, HPC infrastructures for computational acceleration and advanced visualization techniques. AEGLE will: - Realize a multiparametric platform using algorithms for analysing big biodata including features such as volume properties, communication metrics and bottlenecks, estimation of related computational resources needed, handling data versatility and managing velocity - Address the systemic health big bio-data in terms of the 3V multidimensional space, using analytics based on PCA techniques - Demonstrate AEGLE’s efficiency through the provision of aggregated services covering the 3V space of big bio-data. Specifically it will be evaluated in: a)big biostreams where the decision speed is critical and needs non-linear and multi-parametric estimators for clinical decision support within limited time, b)big-data from non-malignant diseases where the need for NGS and molecular data analytics requires the combination of cloud located resources, coupled with local demands for data and visualization, and finally c)big-data from chronic diseases including EHRs and medication, with needs for quantified estimates of important clinical parameters, semantics’ extraction and regulatory issues for integrated care - Bring together all related stakeholders, leading to integration with existing open databases, increasing the speed of AEGLE adaptation - Build a business ecosystem for the wider exploitation and targeting on cross-border production of custom multi-lingual solutions based on AEGLE.

Deliverables

List of deliverables.
Business and HTA framework	Documents, reports	2019-05-30 17:02:34
Final system design	Documents, reports	2019-05-30 17:02:30
AEGLE final strategy, business evaluation and feasibility analysis	Documents, reports	2019-05-30 17:02:34
AEGLE Certification	Demonstrators, pilots, prototypes	2019-05-30 17:02:19
AEGLE third prototype	Demonstrators, pilots, prototypes	2019-05-30 17:02:27
Projectâ€™s Promotional material	Websites, patent fillings, videos etc.	2019-05-30 17:02:18
Final components for local, cloud-level BigData Analytics and Applications	Other	2019-05-30 17:02:25
Projectâ€™s Stationary	Websites, patent fillings, videos etc.	2019-05-30 17:02:20
AEGLE Best Practices	Open Research Data Pilot	2019-05-30 17:02:21
AEGLE product	Demonstrators, pilots, prototypes	2019-05-30 17:02:25
Market Research Report	Documents, reports	2019-05-30 17:02:20
Projectâ€™s Website	Websites, patent fillings, videos etc.	2019-05-30 17:02:21
AEGLE Legal Framework	Documents, reports	2019-05-30 17:02:17

Take a look to the deliverables list in detail: detailed list of AEGLE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2016	Larry Mansouri, Nikos Papakonstantinou, Stavroula Ntoufa, Kostas Stamatopoulos, Richard Rosenquist NF-ÎºB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions published pages: 40-48, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2016.07.005	Seminars in Cancer Biology 39	2019-05-30
2016	John Rumbold; Barbara Pierscionek Reply to Why patients shouldn\'t â€œownâ€ their medical records published pages: 586-587, ISSN: 1087-0156, DOI: 10.1038/nbt.3615	Nature Biotechnology 34/6	2019-05-30
2016	P. Baliakas, M. Mattsson, K. Stamatopoulos, R. Rosenquist Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed? published pages: 347-357, ISSN: 0954-6820, DOI: 10.1111/joim.12455	Journal of Internal Medicine 279/4	2019-05-30
2017	Katerina Vaporidi, Dimitris Babalis, Achilleas Chytas, Emmanuel Lilitsis, Eumorfia Kondili, Vasilis Amargianitakis, Ioanna Chouvarda, Nicos Maglaveras, Dimitris Georgopoulos Clusters of ineffective efforts during mechanical ventilation: impact on outcome published pages: 184-191, ISSN: 0342-4642, DOI: 10.1007/s00134-016-4593-z	Intensive Care Medicine 43/2	2019-05-30
2017	John M. M. Rumbold, Barbara K. Pierscionek A critique of the regulation of data science in healthcare research in the European Union published pages: , ISSN: 1472-6939, DOI: 10.1186/s12910-017-0184-y	BMC Medical Ethics 18/1	2019-05-30
2016	E Young, D Noerenberg, L Mansouri, V LjungstrÃ¶m, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B DÃ¶rken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist, F Damm EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia published pages: 1547-1554, ISSN: 0887-6924, DOI: 10.1038/leu.2016.359	Leukemia 31/7	2019-05-30
2016	A. Vardi, A. Agathangelidis, E. Stalika, M. Karypidou, A. Siorenta, A. Anagnostopoulos, R. Rosenquist, A. Hadzidimitriou, P. Ghia, L.-A. Sutton, K. Stamatopoulos Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia published pages: 167-174, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-14-3017	Clinical Cancer Research 22/1	2019-05-30
2016	V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, R. Clifford, L.-A. Sutton, S. J. Blakemore, N. Stavroyianni, A. Agathangelidis, D. Rossi, M. Hoglund, J. Kotaskova, G. Juliusson, C. Belessi, N. Chiorazzi, P. Panagiotidis, A. W. Langerak, K. E. Smedby, D. Oscier, G. Gaidano, A. Schuh, F. Davi, C. Pott, J. C. Strefford, L. Trentin, S. Pospisilova, P. Ghia, K. Stamatopoulos, T. Sjoblom, R. Rosenquist Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations published pages: 1007-1016, ISSN: 0006-4971, DOI: 10.1182/blood-2015-10-674572	Blood 127/8	2019-05-30
2016	V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek \"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres\" published pages: e369-e373, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.142968	Haematologica 101/9	2019-05-30
2016	V. Bikos, M. Karypidou, E. Stalika, P. Baliakas, A. Xochelli, L.-A. Sutton, G. Papadopoulos, A. Agathangelidis, E. Papadopoulou, Z. Davis, P. Algara, G. Kanellis, A. Traverse-Glehen, M. Mollejo, A. Anagnostopoulos, M. Ponzoni, D. Gonzalez, S. Pospisilova, E. Matutes, M. A. Piris, T. Papadaki, P. Ghia, R. Rosenquist, D. Oscier, N. Darzentas, D. Tzovaras, C. Belessi, A. Hadzidimitriou, K. Stamatopoulos *An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-204 Receptors** published pages: 2032-2040, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-15-1170	Clinical Cancer Research 22/8	2019-05-30
2017	John Mark Michael Rumbold, Barbara Pierscionek The Effect of the General Data Protection Regulation on Medical Research published pages: e47, ISSN: 1438-8871, DOI: 10.2196/jmir.7108	Journal of Medical Internet Research 19/2	2019-05-30
2017	Vasileios Tsoutsouras, Dimosthenis Masouros, Sotirios Xydis, Dimitrios Soudris SoftRM published pages: 1-19, ISSN: 1539-9087, DOI: 10.1145/3126562	ACM Transactions on Embedded Computing Systems 16/5s	2019-05-30
2016	L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaidano, S. Pospisilova, F. Davi, P. Ghia, K. Stamatopoulos, R. Rosenquist Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors published pages: 959-967, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.141812	Haematologica 101/8	2019-05-30
2016	Ioannis Kavakiotis, Aliki Xochelli, Andreas Agathangelidis, Grigorios Tsoumakas, Nicos Maglaveras, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Ioannis Vlahavas, Ioanna Chouvarda Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of â€œtowards analysisâ€ in chronic lymphocytic leukaemia published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-016-1044-3	BMC Bioinformatics 17/S5	2019-05-30
2016	K Stamatopoulos, A Agathangelidis, R Rosenquist, P Ghia Antigen receptor stereotypy in chronic lymphocytic leukemia published pages: 282-291, ISSN: 0887-6924, DOI: 10.1038/leu.2016.322	Leukemia 31/2	2019-05-30
2017	Lesley-Ann Sutton, Anastasia Hadzidimitriou, Panagiotis Baliakas, Andreas Agathangelidis, Anton W. Langerak, Stephan Stilgenbauer, Sarka Pospisilova, Zadie Davis, Francesco Forconi, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification published pages: 968-971, ISSN: 0390-6078, DOI: 10.3324/haematol.2017.165605	Haematologica 102/6	2019-05-30
2016	Georgios Zervakis, Kostas Tsoumanis, Sotirios Xydis, Dimitrios Soudris, Kiamal Pekmestzi Design-Efficient Approximate Multiplication Circuits Through Partial Product Perforation published pages: 3105-3117, ISSN: 1063-8210, DOI: 10.1109/TVLSI.2016.2535398	IEEE Transactions on Very Large Scale Integration (VLSI) Systems 24/10	2019-05-30
2017	Ioannis Kavakiotis, Olga Tsave, Athanasios Salifoglou, Nicos Maglaveras, Ioannis Vlahavas, Ioanna Chouvarda Machine Learning and Data Mining Methods in Diabetes Research published pages: 104-116, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2016.12.005	Computational and Structural Biotechnology Journal 15	2019-05-30
2016	P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. KotaÂ kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference published pages: e299-e302, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.140202	Haematologica 101/7	2019-05-30
2017	John Rumbold, Barbara Pierscionek Does your electronic butler owe you a duty of confidentiality? published pages: , ISSN: 2194-4164, DOI: 10.9785/cri-2017-0206	Computer Law Review International 18/2	2019-05-30
2016	S. Pospisilova, L.-A. Sutton, J. Malcikova, E. Tausch, D. Rossi, E. Montserrat, C. Moreno, K. Stamatopoulos, G. Gaidano, R. Rosenquist, P. Ghia Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go? published pages: 263-265, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.139246	Haematologica 101/3	2019-05-30
2016	Chrysi Panopoulou, Christos Maramis, Nicos Maglaveras, Ioanna Chouvarda Novel Methods for Correcting Next Generation Sequencing Errors in the Î² Chainof T Cell Receptors published pages: 529-534, ISSN: , DOI: 10.1007/978-3-319-32703-7_103		2019-05-30
2016	R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond published pages: 1002-1009, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.134510	Haematologica 101/9	2019-05-30
2016	Kostas Siozios, Dimitrios Soudris A Customizable Framework for Application Implementation onto 3-D FPGAs published pages: 1-1, ISSN: 0278-0070, DOI: 10.1109/TCAD.2016.2529421	IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems	2019-05-30
2016	Achilleas Chytas, Katerina Vaporidi, Dimitris Babalis, Dimitris Georgopoulos, Nicos Maglaveras, Ioanna Chouvarda Ineffective Efforts in ICU Assisted Ventilation: Feature Extraction and Analysis Platform published pages: 642-650, ISSN: , DOI: 10.1007/978-3-319-44944-9_57		2019-05-30
2015	Lazaros Papadopoulos, Ivan Walulya, Philippas Tsigas, Dimitris Soudris A Systematic Methodology for Optimization of Applications Utilizing Concurrent Data Structures published pages: 1-1, ISSN: 0018-9340, DOI: 10.1109/TC.2015.2479604	IEEE Transactions on Computers	2019-05-30

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