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MeTABLE

Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MeTABLE project word cloud

Explore the words cloud of the MeTABLE project. It provides you a very rough idea of what is the project "MeTABLE" about.

genomics annotated enzymes owns evolution international active bacteria biotechnology mechanisms agents laboratories biomolecules biofuels bioinformatic directed industrial sequencing annotation everyday extreme insights expertise network microorganisms synergistic significantly psychrophilic isolation push analysed unimib discoveries characterization complementarity mesophilic generation establishing samples purpose comsats genomic environmental intend exchange extremophiles sabanci metabolic sequences possess yeasts genomes acquire holds gene molecular academic establishment discover discovery bmr life expression organisms confident environment citizens manufacturing tools cold ordinary facilities cambridge unicam ciliates heterologous cleaning provides technologies valuable genome

Project "MeTABLE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI CAMERINO Organization address address: PIAZZA CAVOUR 19F city: CAMERINO postcode: 62032 website: www.unicam.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.metable.eu/metable/
Total cost	337˙500 €
EC max contribution	337˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2014
Duration (year-month-day)	from 2014-12-01 to 2018-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI CAMERINO UNIVERSITA DEGLI STUDI DI CAMERINO Organization address address: PIAZZA CAVOUR 19F city: CAMERINO postcode: 62032 website: www.unicam.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CAMERINO)	coordinator	81˙000.00
2	EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS Organization address address: Teknopark Istanbul, Sanayi Mh. Teknopark Blv. No: 1/4A Kulucka Merkezi, Pendik city: ISTANBUL postcode: 34906 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TR (ISTANBUL)	participant	130˙500.00
3	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	58˙500.00
4	BIOMOLECULAR RESEARCH GENOMICS SRL BIOMOLECULAR RESEARCH GENOMICS SRL Organization address address: VIA REDIPUGLIA 21A city: PADOVA postcode: 35131 website: www.bmr-genomics.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	participant	45˙000.00
5	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	22˙500.00
6	ELVESYS ELVESYS Organization address address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY city: PARIS postcode: 75011 website: www.elvesys.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	0.00
7	COMSATS INSTITUTE OF INFORMATION TECHNOLOGY COMSATS INSTITUTE OF INFORMATION TECHNOLOGY Organization address address: Park Road, Chak Shahzad city: Islamabad postcode: 44000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PK (Islamabad)	partner	0.00

Map

Project objective

The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens.

Deliverables

List of deliverables.
Optimized biomolecules	Other	2019-08-06 18:17:09
Patents	Websites, patent fillings, videos etc.	2019-08-06 18:17:09
optimized molecules for bioremediation	Other	2019-08-06 18:17:09
patent on optimized biomolecules	Websites, patent fillings, videos etc.	2019-08-06 18:17:09
Characterized new biocatalists	Other	2019-08-06 18:17:08
genome annotations	Other	2019-08-06 18:17:07
E. focardii genome database and identification of sequences encoding molecules of interest for industrial applications.	Documents, reports	2019-08-06 18:17:08
proposals for new projects	Documents, reports	2019-08-06 18:17:08
Web page ,Twitter and Facebook account	Documents, reports	2019-08-06 18:17:07
reports on new biocatalists	Documents, reports	2019-08-06 18:17:06
Isolation of microbes that can survive to extreme environments for cultivation when possible that can survive to extreme environments for cultivation when possibles	Other	2019-08-06 18:17:07
characterization of biocatalysts of interest	Other	2019-08-06 18:17:07
Characterized new metabolic pathways	Other	2019-08-06 18:17:08
Improved bioinformatics tools	Documents, reports	2019-08-06 18:17:07
Joint publications concerning WP1-WP5	Documents, reports	2019-08-06 18:17:08
New insight on the molecular mechanisms responsible for cold-adaptation and/or environmental adaptation	Documents, reports	2019-08-06 18:17:07
metagenome sequence and annotation	Documents, reports	2019-08-06 18:17:07
New rules for system biology	Documents, reports	2019-08-06 18:17:07
patenting and industrial applications	Documents, reports	2019-08-06 18:17:07
trained researchers on bioinformatics	Other	2019-08-06 18:17:07

Take a look to the deliverables list in detail: detailed list of MeTABLE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Alessio Mancini, Sandra Pucciarelli Antibiotic activity of the antioxidant drink effective Microorganism-X (EM-X) extracts against common nosocomial pathogens: an in vitro study published pages: 1-6, ISSN: 1478-6419, DOI: 10.1080/14786419.2018.1517344	Natural Product Research	2019-10-08
2018	Alessio Mancini, Filmon Eyassu, Maxwell Conway, Annalisa Occhipinti, Pietro LiÃ², Claudio Angione, Sandra Pucciarelli CiliateGEM: an open-project and a tool for predictions of ciliate metabolic variations and experimental condition design published pages: 1-11, ISSN: 1471-2105, DOI: 10.1186/s12859-018-2422-9	BMC Bioinformatics 19/S15	2019-08-06
2018	Alessandro Pischedda, Kesava Priyan Ramasamy, Marco Mangiagalli, Federica Chiappori, Luciano Milanesi, Cristina Miceli, Sandra Pucciarelli, Marina Lotti Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33127-1	Scientific Reports 8/1	2019-08-06
2018	Aleksei Kaleda, Lotem Haleva, Guy Sarusi, Tova Pinsky, Marco Mangiagalli, Maya Bar Dolev, Marina Lotti, Marco Nardini, Ido Braslavsky Saturn-Shaped Ice Burst Pattern and Fast Basal Binding of an Ice-Binding Protein from an Antarctic Bacterial Consortium published pages: , ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b01914	Langmuir	2019-08-06
2019	Tyler D.R. Vance, Maddalena Bayer-Giraldi, Peter L. Davies, Marco Mangiagalli Ice-binding proteins and the â€˜domain of unknown functionâ€™ 3494 family published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14764	The FEBS Journal	2019-08-06
2018	M. Lotti, S. Brocca, M. Mangiagalli, A. Pischedda, M. Orlando, S. Maione, D. De Pascale, S. Pucciarelli, M. Nardini, I. Braslavsky Enzymes and ice binding proteins from Antarctic organisms published pages: S43-S44, ISSN: 1871-6784, DOI: 10.1016/j.nbt.2018.05.091	New Biotechnology 44	2019-08-06
2017	Katre Juganson, Monika Mortimer, Angela Ivask, Sandra Pucciarelli, Cristina Miceli, Kaja OrupÃµld, Anne Kahru Mechanisms of toxic action of silver nanoparticles in the protozoan Tetrahymena thermophila : From gene expression to phenotypic events published pages: , ISSN: 0269-7491, DOI: 10.1016/j.envpol.2017.03.013	Environmental Pollution	2019-08-06
2018	Marco Mangiagalli, Guy Sarusi, Aleksei Kaleda, Maya Bar Dolev, Valentina Nardone, Vittoria Federica Vena, Ido Braslavsky, Marina Lotti, Marco Nardini Structure of a bacterial ice binding protein with two faces of interaction with ice published pages: 1653-1666, ISSN: 1742-464X, DOI: 10.1111/febs.14434	The FEBS Journal 285/9	2019-08-06
2017	Guang Yang, Hua Yao, Matteo Mozzicafreddo, Patrizia Ballarini, Sandra Pucciarelli, Cristina Miceli Rational engineering of a cold-adapted Î±-amylase from the Antarctic ciliate Euplotes focardii for simultaneous improvement of thermostability and catalytic activity published pages: AEM.00449-17, ISSN: 0099-2240, DOI: 10.1128/AEM.00449-17	Applied and Environmental Microbiology	2019-08-06

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