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HRPCDMECH TERMINATED

Investigating how pathogen effector recognition by the host plant activates cell death

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HRPCDMECH project word cloud

Explore the words cloud of the HRPCDMECH project. It provides you a very rough idea of what is the project "HRPCDMECH" about.

initiator    encounter    genetics    water    rearrangements    effectors    downstream    programmed    stomata    elusive    accompanied    enhancement    pattern    earth    molecular    microbial    proteolytic    sustain    translation    immune    recognize    crops    place    patterns    suggest    cuticular    pathogens    reverse    pamps    attempt    food    rna    security    light    proteases    hypersensitive    leads    active    hr    communities    detection    deployment    shed    barrier    considering    layer    epidermal    protein    immunity    culminates    landscape    population    diverse    proteolysis    urgently    systematic    devastating    pcd    mrna    modulation    pti    mcs    array    plants    walls    effector    event    showed    nutrients    events    highlighting    manner    cell    takes    synergistic    proteome    entering    modulate    metacaspases    sources    triggered    relies    infection    recognizes    parasitism    eti    host    strategy    orchestrate    pathogen    circumvented    plant    breaching    elucidate    waxy    protected    decapping    selective    cells    first    proteins    temporal    death    strategies   

Project "HRPCDMECH" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.slu.se/en/departments/plant-biology-forest-genetics/research/groups/panagiotis-moschou/research/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

Map

 Project objective

Plants are rich sources of nutrients and water for diverse microbial communities. Some of these communities evolved parasitism as a strategy to access plant nutrients, with devastating results for crops. Plants are protected from infection by a waxy cuticular layer above the walls of epidermal cells. Would-be pathogens breaching this barrier, or entering via stomata, encounter an active plant immune system that specifically recognizes pathogens. Breaching leads to the deployment of two synergistic pathways that orchestrate immune responses. The first relies on the detection of pathogen-associated molecular patterns (PAMPs) and culminates in pattern-triggered immunity (PTI). When the first is circumvented a second array of responses takes place known as effector triggered immunity (ETI). In ETI, host factors known as R proteins recognize pathogen effectors, an event which is accompanied by the execution of a unique programmed cell death (PCD) type known as the hypersensitive response (HR). Although the initiator of the HR-PCD is known to depend on the formation of an effector-R complex, the downstream molecular events remain elusive. Previous results showed that particular proteases known as metacaspases (MCs) modulate HR-PCD, highlighting the importance of proteolysis and proteome rearrangements for HR-PCD modulation. I will attempt to shed light on the rearrangements of the HR-PCD proteome landscape, by studying processes that control it: selective RNA decapping and translation and proteolytic events, in a highly temporal manner using systematic approaches and reverse genetics. This project is expected to elucidate the importance of these processes and provide a detailed analysis of mRNA and protein level rearrangements during HR-PCD. In addition, this project will suggest strategies for enhancement of plant immunity against pathogens, which is urgently needed to sustain food security considering the ever growing earth’s population.

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