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WORMTUMORS

Worm power: Can helminths modify the development of colorectal cancer?

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

WORMTUMORS project word cloud

Explore the words cloud of the WORMTUMORS project. It provides you a very rough idea of what is the project "WORMTUMORS" about.

secretory clinical lower live cancer incidence excretory attempted treat therapeutics fellowship develops model trials anti flow inflammation local helminth mediated exposure spontaneous lifestyle detrimental transfer bowel contributes innate collide disease infectious tumor helminths unknown western impair immune significantly africa generation mice infection world found diseases vivo risk regions chronic infections intrinsic suppressive immunity nature successfully adaptive influences of colour knockout dietary protect vaccination inflammatory metastasis rescue cytometry modulation progression cell gastrointestinal dissect colorectal

Project "WORMTUMORS" data sheet

The following table provides information about the project.

Coordinator	CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.cardiff.ac.uk/people/view/310949-smith-katherine
Total cost	203˙200 €
EC max contribution	203˙200 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-GF
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CARDIFF UNIVERSITY CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	coordinator	203˙200.00
2	UNIVERSITY OF CAPE TOWN UNIVERSITY OF CAPE TOWN Organization address address: PRIVATE BAG X3 city: RONDEBOSCH postcode: 7701 website: www.uct.ac.za contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ZA (RONDEBOSCH)	partner	0.00

Map

Project objective

The incidence of cancer is significantly lower in developing areas such as Africa, than in the Western world. These developing regions have a high incidence of helminth infection, which can protect against immune-mediated diseases and are currently being successfully used within clinical trials as novel therapeutics to treat inflammatory bowel disease. As Africa develops, lifestyle and dietary changes will collide with the presence of chronic infectious disease, such as gastrointestinal helminths, increasing the risk of colorectal cancer. The intrinsic immune-suppressive nature of helminth infections is known to be detrimental to the generation of immune responses to other infections and vaccination, and may also impair anti-tumor responses in vivo. We have recently found that local exposure to helminth products can result in increased tumor cell growth and metastasis. Currently, it is unknown how helminth modulation of immunity influences colorectal cancer incidence and progression. This fellowship proposal will make use of an inflammation-associated and spontaneous model of colorectal cancer to test the impact of live helminth infection and exposure to helminth excretory/secretory products on tumor development. It will further dissect the impact of helminth exposure on the innate and adaptive anti-tumor immune response, using multi-colour flow cytometry and cell-specific knockout mice. Furthermore, rescue of an impact of helminth exposure on anti-tumor immunity will be attempted by in vivo cell transfer. This fellowship aims to increase our understanding of how helminth infection contributes to tumor development and may lead to the design of novel therapeutics to improve tumor immunity.

Publications

List of publications.
year	authors and title	journal	last update
2018	Brittany-Amber Jacobs, Alisha Chetty, William Gordon Charles Horsnell, Georgia SchÃ¤fer, Sharon Prince, Katherine Ann Smith Hookworm exposure decreases human papillomavirus uptake and cervical cancer cell migration through systemic regulation of epithelial-mesenchymal transition marker expression published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30058-9	Scientific Reports 8/1	2019-07-25
2015	K A Smith, K J Filbey, L A Reynolds, J P Hewitson, Y Harcus, L Boon, T Sparwasser, G HÃ¤mmerling, R M Maizels Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths published pages: 428-443, ISSN: 1933-0219, DOI: 10.1038/mi.2015.73	Mucosal Immunology 9/2	2019-07-25
2017	Andrew Godkin, Katherine A. Smith Chronic infections with viruses or parasites: breaking bad to make good published pages: 389-396, ISSN: 0019-2805, DOI: 10.1111/imm.12703	Immunology 150/4	2019-07-25

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