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MYO-DESMOPLASIA SIGNED

Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MYO-DESMOPLASIA project word cloud

Explore the words cloud of the MYO-DESMOPLASIA project. It provides you a very rough idea of what is the project "MYO-DESMOPLASIA" about.

stromal    microscopy    techniques    atomic    explore    concentrations    professional    place    interplay    cutting    genes    alone    international    employed    patho    reaction    takes    force    solid    cultured    alterations    sectoral    tumor    complementary    maturity    acquire    light    desmoplastic    training    myofibroblasts    time    hypothesis    reduce    physiology    stiffness    survival    tumors    ecm    topography    components    poses    determines    encoding    barrier    progression    fibroblasts    career    absence    models    mainly    scientific    additive    extracellular    cancer    patients    mechanisms    nano    mobility    edge    determined    fluorescence    anti    desmoplasia    expression    drug    position    pattern    pcr    proposes    agents    skills    personalized    cells    morphodynamic    inter    matrix    elucidate    tunable    activation    extensive    combination    fellow    transforming    subsequently    modulating    mechanical    beta    collagen    form    behavior    model    plan    tgf   

Project "MYO-DESMOPLASIA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Project website http://www.ucy.ac.cy/cancer_biophysics/en/myodesmoplasia
 Total cost 163˙648 €
 EC max contribution 163˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 163˙648.00

Map

 Project objective

In many tumors a desmoplastic reaction takes place during progression, which results in extensive production of collagen by stromal cells of the tumor, mainly fibroblasts and myofibroblasts. Tumor desmoplasia determines in large part the patho-physiology of solid tumors and poses a major barrier to effective drug delivery, affecting the overall survival of cancer patients. Here, the applicant proposes to test the hypothesis that the increase in extracellular matrix (ECM) stiffness and transforming growth factor-beta (TGFβ) activation often observed during tumor progression have additive effects on tumor desmoplasia. Therefore, targeting any of these parameters alone or in combination can reduce the desmoplastic response of the stromal cells. To explore this hypothesis, a combination of cutting-edge techniques will be employed. Specifically, a collagen ECM model, with pre-determined topography and tunable stiffness will be developed. Subsequently, fibroblasts and myofibroblasts will be cultured in the ECM models. Cells nano-mechanical behavior and their morphodynamic alterations will be investigated with Atomic Force Microscopy and light/fluorescence microscopy under the presence or absence of TGFβ or anti-TGFβ agents. Finally, the effects of matrix stiffness along with different TGFβ concentrations in the expression pattern of genes encoding ECM components will be investigated using real-time PCR. The research results will elucidate the mechanisms of the interplay between matrix stiffness and TGFβ production in modulating the ability of fibroblasts and myofibroblasts to form tumor desmoplasia. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, international and inter-sectoral mobility will reach a position of professional maturity in research.

 Publications

year authors and title journal last update
List of publications.
2017 Andreas Stylianou
Atomic Force Microscopy for Collagen-Based Nanobiomaterials
published pages: 1-14, ISSN: 1687-4110, DOI: 10.1155/2017/9234627
Journal of Nanomaterials 2017 2019-06-14
2016 Andreas Stylianou, Triantafyllos Stylianopoulos
Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components
published pages: 33-46, ISSN: 2191-1630, DOI: 10.1007/s12668-015-0187-4
BioNanoScience 6/1 2019-06-14
2017 S V Kontomaris, A Stylianou
Atomic force microscopy for university students: applications in biomaterials
published pages: 33003, ISSN: 0143-0807, DOI: 10.1088/1361-6404/aa5cd6
European Journal of Physics 38/3 2019-06-14

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