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MYO-DESMOPLASIA SIGNED

Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MYO-DESMOPLASIA project word cloud

Explore the words cloud of the MYO-DESMOPLASIA project. It provides you a very rough idea of what is the project "MYO-DESMOPLASIA" about.

tunable    training    elucidate    mainly    tumor    alone    genes    fluorescence    additive    atomic    ecm    force    determines    employed    extensive    techniques    fibroblasts    light    drug    agents    barrier    anti    activation    patho    topography    reaction    extracellular    skills    takes    sectoral    pattern    career    beta    place    encoding    mobility    determined    modulating    morphodynamic    inter    form    collagen    maturity    matrix    mechanical    mechanisms    position    behavior    professional    microscopy    desmoplasia    time    hypothesis    pcr    components    scientific    cultured    international    patients    cutting    plan    transforming    stromal    reduce    acquire    interplay    solid    model    proposes    survival    tgf    stiffness    cells    fellow    absence    alterations    personalized    edge    poses    cancer    complementary    physiology    explore    models    combination    progression    nano    myofibroblasts    concentrations    subsequently    desmoplastic    tumors    expression   

Project "MYO-DESMOPLASIA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Project website http://www.ucy.ac.cy/cancer_biophysics/en/myodesmoplasia
 Total cost 163˙648 €
 EC max contribution 163˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 163˙648.00

Map

 Project objective

In many tumors a desmoplastic reaction takes place during progression, which results in extensive production of collagen by stromal cells of the tumor, mainly fibroblasts and myofibroblasts. Tumor desmoplasia determines in large part the patho-physiology of solid tumors and poses a major barrier to effective drug delivery, affecting the overall survival of cancer patients. Here, the applicant proposes to test the hypothesis that the increase in extracellular matrix (ECM) stiffness and transforming growth factor-beta (TGFβ) activation often observed during tumor progression have additive effects on tumor desmoplasia. Therefore, targeting any of these parameters alone or in combination can reduce the desmoplastic response of the stromal cells. To explore this hypothesis, a combination of cutting-edge techniques will be employed. Specifically, a collagen ECM model, with pre-determined topography and tunable stiffness will be developed. Subsequently, fibroblasts and myofibroblasts will be cultured in the ECM models. Cells nano-mechanical behavior and their morphodynamic alterations will be investigated with Atomic Force Microscopy and light/fluorescence microscopy under the presence or absence of TGFβ or anti-TGFβ agents. Finally, the effects of matrix stiffness along with different TGFβ concentrations in the expression pattern of genes encoding ECM components will be investigated using real-time PCR. The research results will elucidate the mechanisms of the interplay between matrix stiffness and TGFβ production in modulating the ability of fibroblasts and myofibroblasts to form tumor desmoplasia. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, international and inter-sectoral mobility will reach a position of professional maturity in research.

 Publications

year authors and title journal last update
List of publications.
2017 Andreas Stylianou
Atomic Force Microscopy for Collagen-Based Nanobiomaterials
published pages: 1-14, ISSN: 1687-4110, DOI: 10.1155/2017/9234627
Journal of Nanomaterials 2017 2019-06-14
2016 Andreas Stylianou, Triantafyllos Stylianopoulos
Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components
published pages: 33-46, ISSN: 2191-1630, DOI: 10.1007/s12668-015-0187-4
BioNanoScience 6/1 2019-06-14
2017 S V Kontomaris, A Stylianou
Atomic force microscopy for university students: applications in biomaterials
published pages: 33003, ISSN: 0143-0807, DOI: 10.1088/1361-6404/aa5cd6
European Journal of Physics 38/3 2019-06-14

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