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MIDOC

Multimodal Imaging of Disorders of Consciousness

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIDOC project word cloud

Explore the words cloud of the MIDOC project. It provides you a very rough idea of what is the project "MIDOC" about.

degree    fronto    emerged    imaging    frequency    neural    gt    treatment    disorder    magnetic    parietal    diagnosis    occurs    invasive    behavioural    simultaneously    training    manifestations    fundamental    consciousness    transferable    neuroimaging    measured    oscillations    establishing    underlying    thalamo    independent    life    spatial    levels    decisions    widen    connectivity    integrating    conscious    difficult    palliative    techniques    percentage    limited    40    complexity    emergence    misdiagnosis    description    descriptions    electroencephalography    mechanism    scientific    alterations    unknown    functional    brain    proposing    resolutions    proper    anatomy    cortical    data    breakdown    competences    correlate    secure    diminished    temporal    resonance    diffusion    anatomical    rhythms    disorders    plan    prognosis    researcher    tensor    impairment    implications    synergy    signatures    tools    career    neurophysiological    position    tool    severity    hypotheses    individuals    patients    care    single    relate    skills    group   

Project "MIDOC" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://icm-institute.org/en/team/team-bartolomeo-cohen-naccache/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

The diagnosis of individuals with disorders of consciousness has fundamental implications in terms of prognosis, treatment, palliative care and even proper end-of-life decisions. Diagnosis based on behavioural assessment is difficult and it is believed that misdiagnosis occurs in a large percentage of cases (> 40%). Non-invasive functional brain imaging has recently emerged as a promising tool for the diagnosis of individuals with disorders of consciousness; however, different imaging methods allow descriptions at limited spatial and temporal resolutions, and it is unknown how these findings relate to each other, to the underlying brain anatomy, and whether they are manifestations of a single fundamental mechanism underlying the impairment of conscious awareness.

The proposed research project aims to investigate individuals with disorders of consciousness by simultaneously applying these different neuroimaging techniques, thus integrating neurophysiological data across description levels and evaluating their synergy for the objective diagnosis and prognosis of patients. We address the hypotheses that alterations in brain rhythms (measured with electroencephalography) typical of individuals with disorders of consciousness (such as the emergence of low-complexity and low-frequency neural oscillations) are related to diminished fronto-parietal activity and a breakdown of thalamo-cortical functional and anatomical connectivity (functional magnetic resonance imaging; diffusion tensor imaging) and that these signatures of consciousness correlate with the severity of the disorder and the degree of conscious awareness of the patients.

In addition, we are proposing a career development plan for the applicant that includes training on scientific and transferable skills. This plan will both widen his scientific competences and provide him with the tools and experience necessary to secure a position as a leading independent researcher by establishing his own group.

 Publications

year authors and title journal last update
List of publications.
2018 Federico Cavanna, Martina G. Vilas, Matías Palmucci, Enzo Tagliazucchi
Dynamic functional connectivity and brain metastability during altered states of consciousness
published pages: 383-395, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.09.065
NeuroImage 180 2020-01-29
2019 Charlotte Martial, Héléna Cassol, Vanessa Charland-Verville, Carla Pallavicini, Camila Sanz, Federico Zamberlan, Rocío Martínez Vivot, Fire Erowid, Earth Erowid, Steven Laureys, Bruce Greyson, Enzo Tagliazucchi
Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports
published pages: 52-69, ISSN: 1053-8100, DOI: 10.1016/j.concog.2019.01.011
Consciousness and Cognition 69 2020-01-29
2018 Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Carla Pallavicini, Fire Erowid, Earth Erowid, Enzo Tagliazucchi
The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines
published pages: , ISSN: 1662-5145, DOI: 10.3389/fnint.2018.00054
Frontiers in Integrative Neuroscience 12 2020-01-29

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The information about "MIDOC" are provided by the European Opendata Portal: CORDIS opendata.

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