ORSETOSY
Organocatalysis at the service of total synthesis: Madangamine alkaloids
Total Cost €
0EC-Contrib. €
0Partnership
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0ORSETOSY project word cloud
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Project "ORSETOSY" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://dixon.chem.ox.ac.uk/ |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-27 to 2017-04-26 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 183˙454.00 |
Map
Project objective
This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the madangamine alkaloids B, C and E based on a novel organocatalytic desymmetrization reaction as a key step, which will allow the rapid and efficient construction of the BC rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different madangamines and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development via organocatalysis and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Ãngel L. Fuentes de Arriba, Elena Lenci, Mahendra Sonawane, Odilon Formery, Darren J. Dixon Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation published pages: 3655-3659, ISSN: 1433-7851, DOI: 10.1002/anie.201612367 |
Angewandte Chemie International Edition 56/13 | 2019-07-24 |
| 2016 |
Angel L. Fuentes de Arriba, Felix Urbitsch, Darren J. Dixon Umpolung synthesis of branched ?-functionalized amines from imines via photocatalytic three-component reductive coupling reactions published pages: 14434-14437, ISSN: 1359-7345, DOI: 10.1039/C6CC09172E |
Chem. Commun. 52/100 | 2019-07-24 |
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