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INFANT MICROBIOTA

Elucidating how Bifidobacteria shapes the microbiota in response to infant diet.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INFANT MICROBIOTA project word cloud

Explore the words cloud of the INFANT MICROBIOTA project. It provides you a very rough idea of what is the project "INFANT MICROBIOTA" about.

microbiota edge colon differ mcsa grow linked impacts mutant bacteria diet metabolic milk model critical ecosystem birth 13c metabolism bifidobacteria life pioneer suggesting altered variety genome metabolites pseudocatenulatum transposon construction library colonized tracer defense infants hypothesize 16s mechanism mutants risk rrna gut after cutting formula diseases diversity immune mutagenesis byproducts levels mechanisms stable experiments regulatory establishing adaption healthy provides composition supplement put colonisation members gene bacterial isolates colonised elucidate monitoring bifidobacterial host identity unknown infant microbial unable health function fed genomic breast

Project "INFANT MICROBIOTA" data sheet

The following table provides information about the project.

Coordinator	QUADRAM INSTITUTE BIOSCIENCE Organization address address: QUADRAM INSTITUTE BIOSCIENCE NORWICH RESEARCH PARK city: NORWICH postcode: NR4 7UQ website: www.ifr.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://halllab.co.uk/people/melissa-lawson/
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2017-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	QUADRAM INSTITUTE BIOSCIENCE QUADRAM INSTITUTE BIOSCIENCE Organization address address: QUADRAM INSTITUTE BIOSCIENCE NORWICH RESEARCH PARK city: NORWICH postcode: NR4 7UQ website: www.ifr.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	coordinator	152˙879.00
2	UNIVERSITY OF EAST ANGLIA UNIVERSITY OF EAST ANGLIA Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ website: http://www.uea.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	participant	30˙575.00

Map

Project objective

After birth we are colonized by a consortium of bacteria that are critical for health. Bifidobacteria represent pioneer members, and reach high levels within the gut microbiota of breast-fed infants. These bacteria are proposed to be critical for establishing ‘healthy’ microbiota development and immune defense; however the mechanisms remain unknown. We hypothesize that breast-milk metabolism by Bifidobacteria provides microbial-derived metabolic products key to promoting stable colonisation of other members in the microbiota, suggesting a mechanism as to why formula-fed infants have an altered microbiota and associated increased risk to a variety of diseases. This MCSA seeks to elucidate the function of Bifidobacteria with host diet, by developing a model colon ecosystem colonised with defined infant bacterial isolates to identify key bifidobacterial-derived metabolic byproducts that differ between breast milk and formula metabolism using cutting-edge metabolic tracer experiments and [13C]-Bifidobacteria pseudocatenulatum. Aim 2 will determine the genomic and regulatory elements in B. pseudocatenulatum required for adaption/metabolism of breast-milk or infant formula in the model colon via construction of a genome-wide mutant library generated by high through-put transposon mutagenesis. Metabolites identified in aim 1 will be linked to specific bifidobacterial gene function, based on the identity of essential mutants unable to grow in the presence of breast-milk (aim 2). We will also determine how host diet impacts microbiota composition in the model ecosystem, by monitoring microbial diversity by 16S rRNA analysis. Finally, to promote a ‘healthy’ microbiota, identified breast-milk metabolites will be used to supplement the formula fed model. This research will provide critical insight into the function and mechanism of how infant diet impacts bifidobacteria colonisation, with the potential to identify key bifidobacterial-metabolites that promote life-long health.

Publications

List of publications.
year	authors and title	journal	last update
2016	Koshika Yadava, Paul Bollyky, Melissa A. Lawson The formation and function of tertiary lymphoid follicles in chronic pulmonary inflammation published pages: 262-269, ISSN: 0019-2805, DOI: 10.1111/imm.12649	Immunology 149/3	2019-07-24

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