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MELGEN SIGNED
MELanoma GENetics - understanding and biomarking the genetic and immunological determinants of melanoma survival
Total Cost €
0EC-Contrib. €
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0MELGEN project word cloud
Explore the words cloud of the MELGEN project. It provides you a very rough idea of what is the project "MELGEN" about.
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Project "MELGEN" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY OF LEEDS
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://www.melgen.org |
| Total cost | 3˙988˙365 € |
| EC max contribution | 3˙988˙365 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2014 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2019-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY OF LEEDS | UK (LEEDS) | coordinator | 819˙863.00 |
| 2 | LUNDS UNIVERSITET | SE (LUND) | participant | 790˙977.00 |
| 3 | UNIVERSITAETSKLINIKUM ESSEN | DE (ESSEN) | participant | 747˙649.00 |
| 4 | OSLO UNIVERSITETSSYKEHUS HF | NO (OSLO) | participant | 572˙550.00 |
| 5 | GENOME RESEARCH LIMITED | UK (LONDON) | participant | 546˙575.00 |
| 6 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 510˙748.00 |
Map
Project objective
MELGEN (MELanoma GENetics) – understanding and biomarking the genetic and immunological determinants of melanoma survival
The MELGEN European Training Network (ETN) will create an environment for long-term, collaborative, inter-sectorial cancer genetics research with the ultimate aim of improving precision (personalised) medicine. In a 2012 report the European Science Foundation identified the importance of precision medicine and recommended that there should be 1) provision of comprehensive, accessible and interoperable datasets 2) improved models and decision-making processes, 3) interdisciplinary, public-private partnerships and translational research, and 4) dedicated funding including access to core technology and frameworks for education and training of professionals. This application addresses all four recommendations and applies them to melanoma. Considerable, but insufficient, progress has been made in understanding the genetic changes within melanomas that drive tumour progression, and how those drivers can be targeted to treat melanoma. Melanoma is also an especially immunogenic cancer and much more needs to be understood of how melanomas suppress host immunological responses. Understanding what controls immunity in melanoma will be potentially applicable to other cancers. Finally, we need prognostic and predictive biomarkers for selection of precision therapy. This ETN will recruit 15 early stage researchers (ESRs) to address these issues. It will bring together leaders in clinical research, genomics, statistics, bioinformatics, and the biotech industry to exploit the new genomic tools and tumour immunology. MELGEN’s commercial partners are developing immunological tests (ImmunID), bioinformatics (Eagle Genomics), commercial genomics (ServiceXS) and digital design/communications (Digitronix) and they will underpin an innovative, interdisciplinary training programme for the next generation of melanoma researchers.
Deliverables
| D7.1 | Documents, reports | 2019-04-30 15:37:08 |
| D6.2 | Other | 2019-04-30 15:37:08 |
| D6.1 | Other | 2019-04-30 15:37:08 |
Take a look to the deliverables list in detail: detailed list of MELGEN deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Shamik Mitra, Martin Lauss, Rita Cabrita, Jiyeon Choi, Tongwu Zhang, Karolin Isaksson, Håkan Olsson, Christian Ingvar, Ana Carneiro, Johan Staaf, Markus Ringnér, Kari Nielsen, Kevin M. Brown, Göran Jönsson Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma published pages: , ISSN: 1574-7891, DOI: 10.1002/1878-0261.12663 |
Molecular Oncology | 2020-03-13 |
| 2017 |
Rahul Metri, Abhilash Mohan, Jérémie Nsengimana, Joanna Pozniak, Carmen Molina-Paris, Julia Newton-Bishop, David Bishop, Nagasuma Chandra Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach published pages: 17314, ISSN: 2045-2322, DOI: 10.1038/s41598-017-17330-0 |
Scientific Reports 7/1 | 2020-03-05 |
| 2018 |
Sabrina A. Hogan, Mitchell P. Levesque, Phil F. Cheng Melanoma Immunotherapy: Next-Generation Biomarkers published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00178 |
Frontiers in Oncology 8 | 2020-03-05 |
| 2020 |
Metzenmacher, Váraljai, Hegedüs, Cima, Forster, Schramm, Scheffler, Horn, Klein, Szarvas, Reis, Bielefeld, Roesch, Aigner, Kunzmann, Wiesweg, Siveke, Schuler, Lueong Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer published pages: 353, ISSN: 2072-6694, DOI: 10.3390/cancers12020353 |
Cancers 12/2 | 2020-03-05 |
| 2019 |
Marina Juraleviciute, Joanna Pozniak, Jérémie Nsengimana, Mark Harland, Juliette Randersonâ€Moor, Patrik Wernhoff, Assia Bassarova, Geir Frode Øy, Gunhild Trøen, Vivi Ann Flørenes, David Timothy Bishop, Meenhard Herlyn, Julia Newtonâ€Bishop, Ana Slipicevic MX 2 is a novel regulator of cell cycle in melanoma cells published pages: , ISSN: 1755-1471, DOI: 10.1111/pcmr.12837 |
Pigment Cell & Melanoma Research | 2020-03-05 |
| 2019 |
Rohit Thakur, Jonathan P. Laye, Martin Lauss, Joey Mark S. Diaz, Sally Jane O\'Shea, Joanna Poźniak, Anastasia Filia, Mark Harland, Joanne Gascoyne, Juliette A. Randerson-Moor, May Chan, Tracey Mell, Göran Jönsson, D. Timothy Bishop, Julia Newton-Bishop, Jennifer H. Barrett, Jérémie Nsengimana Transcriptomic Analysis Reveals Prognostic Molecular Signatures of Stage I Melanoma published pages: 7424-7435, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-18-3659 |
Clinical Cancer Research 25/24 | 2020-03-05 |
| 2019 |
Anastasia Filia, Alastair Droop, Mark Harland, Helene Thygesen, Juliette Randerson-Moor, Helen Snowden, Claire Taylor, Joey Mark S. Diaz, Joanna Pozniak, Jérémie Nsengimana, Jon Laye, Julia A. Newton-Bishop, D. Timothy Bishop High-Resolution Copy Number Patterns From Clinically Relevant FFPE Material published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45210-2 |
Scientific Reports 9/1 | 2020-03-05 |
| 2017 |
Reinhard Dummer, Egle Ramelyte, Sabrina Schindler, Olaf Thürigen, Mitchell P. Levesque, Peter Koelblinger MEK inhibition and immune responses in advanced melanoma published pages: e1335843, ISSN: 2162-402X, DOI: 10.1080/2162402X.2017.1335843 |
OncoImmunology 6/8 | 2020-03-05 |
| 2019 |
Sabrina A. Hogan, Anaïs Courtier, Phil F. Cheng, Nicoletta F. Jaberg-Bentele, Simone M. Goldinger, Manuarii Manuel, Solène Perez, Nadia Plantier, Jean-François Mouret, Thi Dan Linh Nguyen-Kim, Marieke I.G. Raaijmakers, Pia Kvistborg, Nicolas Pasqual, John B.A.G. Haanen, Reinhard Dummer, Mitchell P. Levesque Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma published pages: 77-85, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-18-0136 |
Cancer Immunology Research 7/1 | 2020-03-05 |
| 2019 |
Joanna Poźniak, Jérémie Nsengimana, Jonathan P. Laye, Sally J. O’Shea, Joey Mark S. Diaz, Alastair P. Droop, Anastasia Filia, Mark Harland, John R. Davies, Tracey Mell, Juliette A. Randerson-Moor, Sathya Muralidhar, Sabrina A. Hogan, Sandra Nicole Freiberger, Mitchell P. Levesque, Graham P. Cook, D. Timothy Bishop, Julia Newton-Bishop Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma published pages: 2684-2696, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-2864 |
Cancer Research 79/10 | 2020-03-05 |
| 2019 |
Sathya Muralidhar, Anastasia Filia, Jérémie Nsengimana, Joanna Poźniak, Sally J. O\'Shea, Joey M. Diaz, Mark Harland, Juliette A. Randerson-Moor, Jörg Reichrath, Jonathan P. Laye, Louise van der Weyden, David J. Adams, D.T. Bishop, Julia Newton-Bishop Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity published pages: 5986-5998, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-3927 |
Cancer Research 79/23 | 2020-03-05 |
| 2018 |
Jérémie Nsengimana, Jon Laye, Anastasia Filia, Sally O’Shea, Sathya Muralidhar, Joanna Poźniak, Alastair Droop, May Chan, Christy Walker, Louise Parkinson, Joanne Gascoyne, Tracey Mell, Minttu Polso, Rosalyn Jewell, Juliette Randerson-Moor, Graham P. Cook, D. Timothy Bishop, Julia Newton-Bishop β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas published pages: 2048-2063, ISSN: 0021-9738, DOI: 10.1172/JCI95351 |
Journal of Clinical Investigation 128/5 | 2020-03-05 |
| 2019 |
Bengt Phung, Maciej Cieśla, Adriana Sanna, Nicola Guzzi, Giulia Beneventi, Phuong Cao Thi Ngoc, Martin Lauss, Rita Cabrita, Eugenia Cordero, Ana Bosch, Frida Rosengren, Jari Häkkinen, Klaus Griewank, Annette Paschen, Katja Harbst, Håkan Olsson, Christian Ingvar, Ana Carneiro, Hensin Tsao, Dirk Schadendorf, Kristian Pietras, Cristian Bellodi, Göran Jönsson The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma published pages: 3573-3586.e7, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.05.069 |
Cell Reports 27/12 | 2020-03-05 |
| 2019 |
Renáta Váraljai, Kilian Wistuba-Hamprecht, Teofila Seremet, Joey Mark S. Diaz, Jérémie Nsengimana, Antje Sucker, Klaus Griewank, Jan-Malte Placke, Peter A. Horn, Nils von Neuhoff, Batool Shannan, Heike Chauvistré, Felix C. E. Vogel, Susanne Horn, Jürgen C. Becker, Julia Newton-Bishop, Andreas Stang, Bart Neyns, Benjamin Weide, Dirk Schadendorf, Alexander Roesch Application of Circulating Cell-Free Tumor DNA Profiles for Therapeutic Monitoring and Outcome Prediction in Genetically Heterogeneous Metastatic Melanoma published pages: 1-10, ISSN: 2473-4284, DOI: 10.1200/po.18.00229 |
JCO Precision Oncology 3 | 2020-03-05 |
| 2018 |
R. Varaljai, N. Neuhoff, A. Sucker, J. Newtonâ€Bishop, D. Schadendorf, A. Roesch 45th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) Zurich, Switzerland, March 7-10, 2018 published pages: e2-e106, ISSN: 0906-6705, DOI: 10.1111/exd.13486 |
Experimental Dermatology 27/3 | 2020-03-05 |
| 2019 |
E. Christodoulou, M. Visser, T. P. Potjer, N. van der Stoep, M. RodrÃguez-Girondo, R. van Doorn, N. Gruis Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers published pages: 439-444, ISSN: 1389-9600, DOI: 10.1007/s10689-019-00137-5 |
Familial Cancer 18/4 | 2020-03-05 |
| 2018 |
S Leonardelli, S Horn, A Sucker, D Schadendorf, K Griewank, A Paschen PO-399 Tumour CDKN2A loss predisposes to immunotherapy resistance published pages: A386.1-A386, ISSN: , DOI: 10.1136/esmoopen-2018-eacr25.911 |
Genomic Alterations in Cancer 3 (Suppl 2) | 2020-03-05 |
| 2019 |
Catarina Salgado, Eliza Mari Kwesi-Maliepaard, Aart G. Jochemsen, Mijke Visser, Mark Harland, Fred van Leeuwen, Remco van Doorn, Nelleke Gruis A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma published pages: 582-589, ISSN: 0960-8931, DOI: 10.1097/cmr.0000000000000640 |
Melanoma Research 29/6 | 2020-03-05 |
| 2020 |
Eirini Christodoulou, Remco van Doorn, Mijke Visser, Amina Teunisse, Mieke Versluis, Pieter van der Velden, Nicholas K Hayward, Aart Jochemsen, Nelleke Gruis NEK11 as a candidate high-penetrance melanoma susceptibility gene published pages: 203-210, ISSN: 0022-2593, DOI: 10.1136/jmedgenet-2019-106134 |
Journal of Medical Genetics 57/3 | 2020-03-05 |
| 2020 |
Rita Cabrita, Martin Lauss, Adriana Sanna, Marco Donia, Mathilde Skaarup Larsen, Shamik Mitra, Iva Johansson, Bengt Phung, Katja Harbst, Johan Vallon-Christersson, Alison van Schoiack, Kristina Lövgren, Sarah Warren, Karin Jirström, Håkan Olsson, Kristian Pietras, Christian Ingvar, Karolin Isaksson, Dirk Schadendorf, Henrik Schmidt, Lars Bastholt, Ana Carneiro, Jennifer A. Wargo, Inge Marie Sva Tertiary lymphoid structures improve immunotherapy and survival in melanoma published pages: 561-565, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1914-8 |
Nature 577/7791 | 2020-03-05 |
| 2018 |
Sofia Y. Chen, Rashid Mamunur, Jon Laye, D. Timothy Bishop, Julia A. Newton-Bishop, David J. Adams Abstract 5372: The mutational landscape of primary cutaneous melanoma published pages: 5372-5372, ISSN: , DOI: 10.1158/1538-7445.am2018-5372 |
Molecular and Cellular Biology / Genetics 78(13 Suppl) | 2020-03-05 |
| 2019 |
Adriana Sanna, Katja Harbst, Iva Johansson, Gustav Christensen, Martin Lauss, Shamik Mitra, Frida Rosengren, Jari Häkkinen, Johan Vallonâ€Christersson, HÃ¥kan Olsson, Ã…sa Ingvar, Karolin Isaksson, Christian Ingvar, Kari Nielsen, Göran Jönsson Tumor genetic heterogeneity analysis of chronic sunâ€damaged melanoma published pages: , ISSN: 1755-1471, DOI: 10.1111/pcmr.12851 |
Pigment Cell & Melanoma Research | 2020-03-05 |
| 2018 |
Carsten Krieg, Malgorzata Nowicka, Silvia Guglietta, Sabrina Schindler, Felix J Hartmann, Lukas M Weber, Reinhard Dummer, Mark D Robinson, Mitchell P Levesque, Burkhard Becher High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy published pages: 144-153, ISSN: 1078-8956, DOI: 10.1038/nm.4466 |
Nature Medicine 24/2 | 2020-03-05 |
| 2019 |
Lazaro Hiram Betancourt, Krzysztof Pawłowski, Jonatan Eriksson, A. Marcell Szasz, Shamik Mitra, Indira Pla, Charlotte Welinder, Henrik Ekedahl, Per Broberg, Roger Appelqvist, Maria Yakovleva, Yutaka Sugihara, Kenichi Miharada, Christian Ingvar, Lotta Lundgren, Bo Baldetorp, Håkan Olsson, Melinda Rezeli, Elisabet Wieslander, Peter Horvatovich, Johan Malm, Göran Jönsson, György Marko-Varga Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41625-z |
Scientific Reports 9/1 | 2020-03-05 |
| 2017 |
Martin Lauss, Marco Donia, Katja Harbst, Rikke Andersen, Shamik Mitra, Frida Rosengren, Maryem Salim, Johan Vallon-Christersson, Therese Törngren, Anders Kvist, Markus Ringnér, Inge Marie Svane, Göran Jönsson Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma published pages: 1738, ISSN: 2041-1723, DOI: 10.1038/s41467-017-01460-0 |
Nature Communications 8/1 | 2020-03-05 |
| 2019 |
Renata Varaljai, Kilian Wistuba-Hamprecht, Teofila Seremet, Joey Mark Santiago Diaz, Jeremie Nsengimana, Antje Sucker, Klaus Griewank, Peter Horn, Nils von Neuhoff, Batool Shannan, Heike Chauvistré, Felix Christian Eduard Vogel, Susanne Horn, Jürgen C. Becker, Julia Newton-Bishop, Andreas Stang, Bart Neyns, Benjamin Weide, Dirk Schadendorf, Alexander Roesch ctDNA as a noninvasive monitoring tool in metastatic melanoma. published pages: 9548-9548, ISSN: 0732-183X, DOI: 10.1200/jco.2019.37.15_suppl.9548 |
Journal of Clinical Oncology 37/15_suppl | 2020-03-05 |
| 2018 |
Multiple abstracts from multiple ESRs: Joanna Pozniak, Sathya Muralidhar, Rohit Thakur, Joey Mark Diaz, Shamik Mitra, Adriana Sanna, Rita Cabrita, Sonia Leonardelli, Ishani Banik SMR Congress 2018 Abstracts published pages: 92-172, ISSN: 1755-1471, DOI: 10.1111/pcmr.12738 |
Pigment Cell & Melanoma Research 32/1 | 2020-03-05 |
| 2018 |
R Varaljai, N Von Neuhoff, A Sucker, J Newton-Bishop, D Schadendorf, A Roesch PO-493 ctDNA profiles of metastatic melanoma patients under therapy published pages: A423.1-A423, ISSN: , DOI: 10.1136/esmoopen-2018-eacr25.995 |
Poster Presentation: Translational Research 3 (Suppl 2) | 2020-03-05 |
| 2018 |
Joanna Pozniak, Jeremie Nsengimana, Jon Laye, Sally O\'Shea, Sabrina Schindler, Mitch Levesque, Tim Bishop, Julia Newton-Bishop Abstract 5204: MYC expression and smoking as drivers of failure of immune response to melanoma published pages: 5204-5204, ISSN: , DOI: 10.1158/1538-7445.am2018-5204 |
Tumor Biology 78(13 Suppl) | 2020-03-05 |
| 2020 |
Catarina Salgado, Jan Oosting, Bart Janssen, Rajiv Kumar, Nelleke Gruis, Remco Doorn Genomeâ€wide characterization of 5â€hydoxymethylcytosine in melanoma reveals major differences with nevus published pages: , ISSN: 1045-2257, DOI: 10.1002/gcc.22837 |
Genes, Chromosomes and Cancer | 2020-03-05 |
| 2018 |
Sathya Muralidhar, Jeremie Nsengimana, Joanna Pozniak, Sally O\'Shea, Jonathan Laye, David Adams, Louise van der Weyden, Timothy Bishop, Julia Newton-Bishop Abstract 5205: Primary melanoma expression of the vitamin D receptor ( VDR ) is protective for melanoma survival and is associated with increased tumor immune response, decreased Wnt/B-catenin signaling and tumor proliferation published pages: 5205-5205, ISSN: , DOI: 10.1158/1538-7445.am2018-5205 |
Tumor Biology 78(13 Suppl) | 2020-03-05 |
| 2016 |
Egle Ramelyte, Sabrina A. Schindler, Reinhard Dummer The safety of anti PD-1 therapeutics for the treatment of melanoma published pages: 41-53, ISSN: 1474-0338, DOI: 10.1080/14740338.2016.1248402 |
Expert Opinion on Drug Safety 16/1 | 2020-03-05 |
| 2018 |
Abstracts from ESRs: Marina Juraleviciute, Sabrina Schindler SMR Congress 2017 abstracts published pages: 125-230, ISSN: 1755-1471, DOI: 10.1111/pcmr.12656 |
Pigment Cell & Melanoma Research 31/1 | 2020-03-05 |
| 2017 |
Mykyta Artomov, Alexander J. Stratigos, Ivana Kim, Raj Kumar, Martin Lauss, Bobby Y. Reddy, Benchun Miao, Carla Daniela Robles-Espinoza, Aravind Sankar, Ching-Ni Njauw, Kristen Shannon, Evangelos S. Gragoudas, Anne Marie Lane, Vivek Iyer, Julia A. Newton-Bishop, D. Timothy Bishop, Elizabeth A. Holland, Graham J. Mann, Tarjinder Singh, Jeffrey Barrett, David J. Adams, Göran Jönsson, Mark J. Daly, Hensin Tsao Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing published pages: , ISSN: 0027-8874, DOI: 10.1093/jnci/djx083 |
JNCI: Journal of the National Cancer Institute 109/12 | 2019-05-27 |
| 2017 |
Simone L. Scholz, Inga Möller, Henning Reis, Daniela Süßkind, Johannes A. P. van de Nes, Sonia Leonardelli, Bastian Schilling, Elisabeth Livingstone, Tobias Schimming, Annette Paschen, Antje Sucker, Rajmohan Murali, Klaus-Peter Steuhl, Dirk Schadendorf, Henrike Westekemper, Klaus G. Griewank Frequent GNAQ, GNA11 , and EIF1AX Mutations in Iris Melanoma published pages: 3464, ISSN: 1552-5783, DOI: 10.1167/iovs.17-21838 |
Investigative Opthalmology & Visual Science 58/9 | 2019-05-27 |
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