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OlfSwitch SIGNED

OlfSwitch: Neural circuit switches from molecules to behaviour

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OlfSwitch project word cloud

Explore the words cloud of the OlfSwitch project. It provides you a very rough idea of what is the project "OlfSwitch" about.

sex put shown genetic drosophila stimulus modulation sexually gates circuit developmental start parallel goals aversive downstream nervous stimuli characterised molecules instructions memory primary time odour valence innate logic convergent first negatively determines transcription olfactory pheromone relevance animal switch simply relatively modules dynamic model motifs triggered layout internal understand switches dimorphic behaviours single elementary hardwire significance physiological probe basis behavioural neural positively examine fruitless attractive

Project "OlfSwitch" data sheet

The following table provides information about the project.

Coordinator	UNITED KINGDOM RESEARCH AND INNOVATION There are not information about this coordinator. Please contact Fabio for more information, thanks.
Coordinator Country	United Kingdom [UK]
Project website	http://jefferislab.org
Total cost	1˙990˙791 €
EC max contribution	1˙990˙791 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	coordinator	1˙537˙995.00
2	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	coordinator	0.00
3	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	452˙796.00

Map

Project objective

This proposal seeks to understand the logic of neural circuit switches in the relatively simple nervous system of Drosophila. Our goals are to examine the developmental, physiological and behavioural logic of several of these elementary circuit motifs. We will use innate olfactory behaviour as our primary model, investigating behaviours triggered by single or convergent odour stimuli and their modulation by memory and internal state. We will start with the favourable case of a sexually dimorphic circuit switch that we have recently characterised (for the first time in any animal). We have shown that a transcription factor, fruitless, determines the state of this switch in sex pheromone processing during development. We will now (1) identify the molecules that determine the layout of this specific circuit during development and (2) probe the behavioural relevance of this specific circuit switch.

In parallel with this work on pheromone processing, we will examine (3) the circuit basis of valence (simply put whether an odour is attractive or aversive) in which genetic instructions likely hardwire olfactory pathways to downstream modules of different behavioural significance. Finally we will examine the logic of dynamic switches in which a second stimulus (4) positively or (5) negatively gates the response to a stimulus.

Publications

List of publications.
year	authors and title	journal	last update
2017	Ben Sutcliffe, Julian Ng, Thomas O. Auer, Mathias Pasche, Richard Benton, Gregory S. X. E. Jefferis, Sebastian Cachero Second-Generation Drosophila Chemical Tags: Sensitivity, Versatility, and Speed published pages: 1399-1408, ISSN: 0016-6731, DOI: 10.1534/genetics.116.199281	Genetics 205/4	2020-01-15
2015	Johannes Kohl, Paavo Huoviala, Gregory SXE Jefferis Pheromone processing in Drosophila published pages: 149-157, ISSN: 0959-4388, DOI: 10.1016/j.conb.2015.06.009	Current Opinion in Neurobiology 34	2020-01-15
2017	Michael-John Dolan, Haojiang Luan, William C. Shropshire, Ben Sutcliffe, Benjamin Cocanougher, Robert L. Scott, Shahar Frechter, Marta Zlatic, Gregory S. X. E. Jefferis, Benjamin H. White Facilitating Neuron-Specific Genetic Manipulations in Drosophila melanogaster Using a Split GAL4 Repressor published pages: 775-784, ISSN: 0016-6731, DOI: 10.1534/genetics.116.199687	Genetics 206/2	2020-01-15
2016	Karin Panser; Laszlo Tirian; Florian Schulze; Santiago Villalba; GregoryÂ S.X.E. Jefferis; Katja BÃ¼hler; AndrewÂ D. Straw Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.05.052	Current Biology 2	2020-01-15
2016	Marta Costa; James D. Manton; Aaron D. Ostrovsky; Steffen Prohaska; Gregory S.X.E. Jefferis NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.06.012	Neuron 3	2020-01-15
2016	Julian Ng; Alyssa Browning; Lorenz Lechner; Masako Terada; Gillian Howard; Gregory Jefferis Genetically targeted 3D visualisation ofDrosophilaneurons under Electron Microscopy and X-Ray Microscopy using miniSOG published pages: , ISSN: 2045-2322, DOI: 10.1101/070755	Scientific Reports 4	2020-01-15

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The information about "OLFSWITCH" are provided by the European Opendata Portal: CORDIS opendata.