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ChromatidCohesion SIGNED

Establishment of Sister Chromatid Cohesion

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ChromatidCohesion project word cloud

Explore the words cloud of the ChromatidCohesion project. It provides you a very rough idea of what is the project "ChromatidCohesion" about.

lays loading stability cell cycle dna basis single complemented shaped cofactors molecular synthesized shaping cohesin ubiquitous again division hydrolysis ring foundation genetic mechanistic generally topological atpase happens family binding chromosomes atp dependent smc following chromatids questions segregating replication newly unloaded capitalise chromatin sister mechanism topologically protein abc encompassing conformational despite load incorporating faithful gained genomes genome chromatid reconstitution synthesis action onto module paired poorly intriguing loaded cohesion atpases biochemical segregation establishes chromosomal structural packages combination life forms molecule machine

Project "ChromatidCohesion" data sheet

The following table provides information about the project.

Coordinator	THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	2˙120˙099 €
EC max contribution	2˙120˙099 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙120˙099.00

Map

Project objective

Following their synthesis during DNA replication, sister chromatids remain paired by the cohesin complex, which forms the basis for their faithful segregation during cell division. Cohesin is a large ring-shaped protein complex, incorporating an ABC-type ATPase module. Despite its importance for genome stability, the molecular mechanism of cohesin action remains as intriguing as it remains poorly understood. How is cohesin topologically loaded onto chromatin? How is it unloaded again? What happens to cohesin during DNA replication in S-phase, so that it establishes cohesion between newly synthesized sister chromatids? We propose to capitalise on our recent success in the biochemical reconstitution of topological cohesin loading onto DNA. This lays the foundation for a work programme encompassing a combination of biochemical, single molecule, structural and genetic approaches to address the above questions. Five work packages will investigate cohesin’s molecular behaviour during its life-cycle on chromosomes, including the ATP binding and hydrolysis-dependent conformational changes that make this molecular machine work. It will be complemented by mechanistic analyses of the cofactors that help cohesin to load onto chromosomes and establish sister chromatid cohesion. The insight gained will not only advance our molecular knowledge of sister chromatid cohesion. It will more generally advance our understanding of the ubiquitous family of chromosomal SMC ATPases, of which cohesin is a member, and their activity of shaping and segregating genomes.

Publications

List of publications.
year	authors and title	journal	last update
2018	Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann Establishment of DNA-DNA Interactions by the Cohesin Ring published pages: 465-477.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.12.021	Cell 172/3	2020-04-06
2016	Frank Uhlmann SMC complexes: from DNA to chromosomes published pages: 399-412, ISSN: 1471-0072, DOI: 10.1038/nrm.2016.30	Nature Reviews Molecular Cell Biology 17/7	2020-04-06
2018	Yasutaka Kakui, Frank Uhlmann SMC complexes orchestrate the mitotic chromatin interaction landscape published pages: 335-339, ISSN: 0172-8083, DOI: 10.1007/s00294-017-0755-y	Current Genetics 64/2	2020-04-06
2017	Yasuto Murayama, Frank Uhlmann An in vitro assay for monitoring topological DNA entrapment by the chromosomal cohesin complex published pages: 23-35, ISSN: , DOI: 10.1007/978-1-4939-6545-8_2	Methods in Molecular Biology 1515	2020-04-06
2015	Yasuto Murayama, Frank Uhlmann DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism published pages: 1628-1640, ISSN: 0092-8674, DOI: 10.1016/j.cell.2015.11.030	Cell 163/7	2020-04-06
2016	Maria Ocampo-Hafalla, SofÃa MuÃ±oz, Catarina P. Samora, Frank Uhlmann Evidence for cohesin sliding along budding yeast chromosomes published pages: 150178, ISSN: 2046-2441, DOI: 10.1098/rsob.150178	Open Biology 6/6	2020-04-06
2016	CatarinaÂ P. Samora, Julie Saksouk, Panchali Goswami, BenÂ O. Wade, MartinÂ R. Singleton, PaulÂ A. Bates, Armelle Lengronne, Alessandro Costa, Frank Uhlmann Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome published pages: 371-384, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.05.036	Molecular Cell 63/3	2020-04-06
2018	Rahul Thadani, Julia Kamenz, Sebastian Heeger, SofÃa MuÃ±oz, Frank Uhlmann Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex published pages: 2308-2317, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.082	Cell Reports 23/8	2020-04-06

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