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BtRAIN SIGNED

Brain barriers training

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BtRAIN project word cloud

Explore the words cloud of the BtRAIN project. It provides you a very rough idea of what is the project "BtRAIN" about.

pathological unusual broad 12 genes business overcome armamentarium validate treatment regulating proper hampered function suited brain career accompanying userfriendly complexity traits diagnostic neurotoxic communication innovative vertebrate severely reliably platform science roles bridges bioinformatics vivo made therapeutic unmet data disease disorders progress entrepreneur pool gap block international interfaces diagnosis create vitro signature alterations drugs young jointly ageing multiple species network capacity health nervous expert motivation barriers hindering market train cns breach unfortunately barrier euopean therapeutics combining alzheimer side untapped tools neurological combined transcriptome models central compounds btrain datamining predict online bbbhub protect cross academic sclerosis

Project "BtRAIN" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://www.btrain-2020.eu/
Total cost	3˙067˙402 €
EC max contribution	3˙067˙402 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2019-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	coordinator	530˙453.00
2	THE OPEN UNIVERSITY THE OPEN UNIVERSITY Organization address address: WALTON HALL city: MILTON KEYNES postcode: MK7 6AA website: www.open.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MILTON KEYNES)	participant	273˙287.00
3	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	265˙226.00
4	UNIVERSITE D'ARTOIS UNIVERSITE D'ARTOIS Organization address address: RUE DU TEMPLE 9 city: ARRAS postcode: 62000 website: www.univ-artois.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ARRAS)	participant	262˙875.00
5	IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE Organization address address: VIA ADAMELLO 16 city: MILANO postcode: 20139 website: www.ifom-firc.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	258˙061.00
6	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
7	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	250˙560.00
8	GENXPRO GMBH GENXPRO GMBH Organization address address: ALTENHOFTER ALLEE 3 city: FRANKFURT postcode: 60438 website: www.genxpro.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT)	participant	249˙216.00
9	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	249˙216.00
10	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	249˙216.00
11	SZEGEDI BIOLOGIAI KUTATOKOZPONT SZEGEDI BIOLOGIAI KUTATOKOZPONT Organization address address: TEMESVARI KORUT 62 city: SZEGED postcode: 6726 website: www1.szbk.u-szeged.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (SZEGED)	participant	223˙913.00
12	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00
13	BRAINS FOR BRAIN FOUNDATION ONLUS BRAINS FOR BRAIN FOUNDATION ONLUS Organization address address: VIA GIUSTINIANI 3 city: PADOVA postcode: 35128 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	partner	0.00
14	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	partner	0.00
15	LAVISION BIOTEC GMBH LAVISION BIOTEC GMBH Organization address address: ASTASTRASSE 14 city: BIELEFELD postcode: 33617 website: www.lavisionbiotec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	partner	0.00
16	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	partner	0.00
17	NCARDIA BV NCARDIA BV Organization address address: GALLILEIWEG 8 city: LEIDEN postcode: 2333 BD website: www.pluriomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	partner	0.00
18	Scitec-media GmbH Scitec-media GmbH Organization address address: n.a. city: Winterthur postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Winterthur)	partner	0.00
19	TP21 GMBH TP21 GMBH Organization address address: LUISENSTRASSE 14 city: BERLIN postcode: 10117 website: www.tp21.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	partner	0.00
20	UNIVERSITY OF SAN DIEGO UNIVERSITY OF SAN DIEGO Organization address address: 5998 ALCALA PARK HUGHES ADMINISTRATION CENTER city: SAN DIEGO postcode: 92110 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (SAN DIEGO)	partner	0.00

Map

Project objective

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.

Publications

List of publications.
year	authors and title	journal	last update
2019	Monica Corada, Fabrizio Orsenigo, Ganesh Parameshwar Bhat, Lei Liu Conze, Ferruccio Breviario, Sara Isabel Cunha, Lena Claesson-Welsh, Galina V. Beznoussenko, Alexander A. Mironov, Marco Bacigaluppi, Gianvito Martino, Mara E. Pitulescu, Ralf H. Adams, Peetra Magnusson, Elisabetta Dejana Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier published pages: 511-525, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.313316	Circulation Research 124/4	2019-10-29
2018	Marco F. Morini, Costanza Giampietro, Monica Corada, Federica Pisati, Elisa Lavarone, Sara I. Cunha, Lei L. Conze, Nicola Oâ€™Reilly, Dhira Joshi, Svend Kjaer, Roger George, Emma Nye, Anqi Ma, Jian Jin, Richard Mitter, Michela Lupia, Ugo Cavallaro, Diego Pasini, Dinis P. Calado, Elisabetta Dejana, Andrea Taddei VE-Cadherinâ€“Mediated Epigenetic Regulation of Endothelial Gene Expression published pages: 231-245, ISSN: 0009-7330, DOI: 10.1161/circresaha.117.312392	Circulation Research 122/2	2019-10-29
2019	Lasse D. Jensen, Belma Hot, Daniel RamskÃ¶ld, Raoul F.V. Germano, Chika Yokota, Sarantis Giatrellis, Volker M. Lauschke, Dirk Hubmacher, Minerva X. Li, Mike Hupe, Thomas D. Arnold, Rickard Sandberg, Jonas FrisÃ©n, Marta Trusohamn, Agnieszka Martowicz, Joanna Wisniewska-Kruk, Daniel Nyqvist, Ralf H. Adams, Suneel S. Apte, Benoit Vanhollebeke, Jan M. Stenman, Julianna Kele Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of Î²-Catenin Signaling published pages: 1432-1447, ISSN: 1079-5642, DOI: 10.1161/atvbaha.119.312388	Arteriosclerosis, Thrombosis, and Vascular Biology 39/7	2019-10-16
2019	Fabienne Benz, Viraya Wichitnaowarat, Martin Lehmann, Raoul FV Germano, Diana Mihova, Jadranka Macas, Ralf H Adams, M Mark Taketo, Karl-Heinz Plate, Sylvaine GuÃ©rit, Benoit Vanhollebeke, Stefan Liebner Low wnt/Î²-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.43818	eLife 8	2019-10-16
2018	Almary Guerra, Raoul FV Germano, Oliver Stone, Rima Arnaout, Stefan Guenther, Suchit Ahuja, VerÃ³nica Uribe, Benoit Vanhollebeke, Didier YR Stainier, Sven Reischauer Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.32833	eLife 7	2019-10-16

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