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SyDAD SIGNED

Synaptic Dysfunction in Alzheimer Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SyDAD project word cloud

Explore the words cloud of the SyDAD project. It provides you a very rough idea of what is the project "SyDAD" about.

environment apart overwhelming decline discovery tackle intersectoral society population companies burden collaborative utilising excellent sydad utilisation generation academia alzheimer ground solid interdisciplinary given dysfunction full commercial talk cross skills ad mind cutting big nervous drug overcome synaptic elaborated retraction training innovation connection failed trials economic methodology cognitive disease underlying components innovative pharmaceutical significantly aging pathology network career therapies clinics private edge century complementary industrial patients suffering transferable dementia point esrs societal platform delineate decrease clinical stage trained urgent expertise

Project "SyDAD" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	3˙846˙736 €
EC max contribution	3˙846˙736 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙054˙637.00
2	UNIVERSITE DE BORDEAUX UNIVERSITE DE BORDEAUX Organization address address: PLACE PEY BERLAND 35 city: BORDEAUX postcode: 33000 website: www.nouvelle-univ-bordeaux.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (BORDEAUX)	participant	788˙626.00
3	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	774˙183.00
4	DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV Organization address address: SIGMUND FREUD STRASSE 27 city: BONN postcode: 53127 website: www.dzne.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	747˙649.00
5	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	250˙560.00
6	AXON NEUROSCIENCE SE AXON NEUROSCIENCE SE Organization address address: DVORAKOVO NABREZIE 10 city: BRATISLAVA postcode: 81102 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SK (BRATISLAVA)	participant	231˙078.00
7	ALZECURE DISCOVERY ALZECURE DISCOVERY Organization address address: KI Science Park, Hälsovägen 7 city: Huddinge postcode: SE14157 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Huddinge)	partner	0.00
8	ALZHEIMER EUROPE ALZHEIMER EUROPE Organization address address: RUE DICKS 14 city: LUXEMBOURG postcode: 1417 website: www.alzheimer-europe.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (LUXEMBOURG)	partner	0.00
9	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	partner	0.00
10	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	partner	0.00
11	SERENDIPITY INNOVATIONS AB SERENDIPITY INNOVATIONS AB Organization address address: STUREPLAN 15 city: STOCKHOLM postcode: 111 45 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	partner	0.00

Map

Project objective

Given an overwhelming increase of dementia costs and an aging population, there is an urgent need for finding novel therapies for Alzheimer Disease (AD). We are, however, facing a large number of failed clinical trials and a retraction of the nervous system R&D programmes from several big pharmaceutical companies. Increased collaboration between academia and the private sector is required to overcome this challenge. The “Synaptic Dysfunction in Alzheimer Disease” (SyDAD) project will significantly contribute to this approach by training a new generation of researchers with experience and full understanding of the requirements of academia, pharmaceutical companies, the clinics and the society. The research programme will focus on synaptic dysfunction, the main connection point between pathology and cognitive decline in AD. Given the complementary expertise, SyDAD will have excellent opportunities to delineate the cross-talk between different pathways underlying synaptic dysfunction in AD and to identify novel pharmaceutical targets. For future implementation of the research findings into clinical trials, a drug discovery platform will be elaborated, utilising the industrial and clinical expertise in the network. The early-stage researchers (ESRs) will be trained in this environment and provided with a mind-set of future commercial and clinical utilisation of their research findings. Apart from the innovative and collaborative approach of the research programme, the ESRs will also be provided with a training programme where cutting-edge methodology, innovation and transferable skills are key components. The trained ESRs will have excellent intersectoral and interdisciplinary career opportunities and will, together with the SyDAD partners, provide a solid ground to tackle one of the major societal challenges of our century: Finding therapies to decrease the suffering and economic burden of AD patients.

Deliverables

List of deliverables.
Publications	Websites, patent fillings, videos etc.	2020-03-24 11:02:43
Half-time control reports and seminars by the ESRs	Documents, reports	2020-03-24 11:02:32
Doctoral degrees	Documents, reports	2020-03-24 11:02:27
Detailed plans for second years training and meetings	Documents, reports	2020-03-24 11:02:43
Detailed plans for third years training and meetings	Documents, reports	2020-03-24 11:02:15
Established website	Websites, patent fillings, videos etc.	2019-10-01 10:07:09
Detailed plans for first years training and meetings	Documents, reports	2019-10-01 10:07:09
ESRs recruited	Documents, reports	2019-10-01 10:07:09
Public dissemination, including workshop with People living with dementia	Documents, reports	2019-10-01 10:07:09

Take a look to the deliverables list in detail: detailed list of SyDAD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Hazal Haytural, Jolanta L. Lundgren, Tansu B. KÃ¶se, TomÃ s JordÃ -Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik SundstrÃ¶m, GaÃ«l Barthet, Lars O. Tjernberg, Susanne Frykman Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2019.00273	Frontiers in Aging Neuroscience 11	2020-01-28
2020	Kina HÃ¶glund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, StÃ©phanie Eyquem, Oskar Hansson, Kaj Blennow Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration published pages: 104645, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2019.104645	Neurobiology of Disease 134	2020-01-28
2019	Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, GaÃ«l Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease published pages: mcp.RA119.001737, ISSN: 1535-9476, DOI: 10.1074/mcp.ra119.001737	Molecular & Cellular Proteomics	2020-01-28
2019	Una Smailovic, Vesna Jelic Neurophysiological Markers of Alzheimerâ€™s Disease: Quantitative EEG Approach published pages: 37-55, ISSN: 2193-8253, DOI: 10.1007/s40120-019-00169-0	Neurology and Therapy 8/S2	2020-01-28
2019	Una Smailovic, Thomas Koenig, Erika J Laukka, GrÃ©goria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic EEG time signature in AlzheimerÂ´s disease: Functional brain networks falling apart published pages: 102046, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.102046	NeuroImage: Clinical 24	2020-01-28
2018	Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar BjÃ¶rkhem, Javier DeFelipe, Angel Cedazo-Minguez 27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons published pages: 429-446, ISSN: 1047-3211, DOI: 10.1093/cercor/bhy274	Cerebral Cortex 29/1	2020-01-28
2018	Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito CalÃ¬, Paola Pizzo, Maria Ankarcrona TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer published pages: 369-382.e6, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.12.047	Current Biology 28/3	2019-10-28
2019	Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, AnaÃ¯s Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40887-x	Scientific Reports 9/1	2019-10-28
2019	Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano Multiâ€omics identify xanthine as a proâ€survival metabolite for nematodes with mitochondrialÂ dysfunction published pages: e99558, ISSN: 0261-4189, DOI: 10.15252/embj.201899558	The EMBO Journal 38/6	2019-10-28
2019	Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca Amyloid-Î² Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena published pages: 7136-7143, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1583-5	Molecular Neurobiology 56/10	2019-10-28
2018	Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka KÃ¤mÃ¤rÃ¤inen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-018-0605-2	Acta Neuropathologica Communications 6/1	2019-10-28
2018	Kostoula Troulinaki, Sven BÃ¼ttner, AnaÃ¯s Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans published pages: , ISSN: 2058-7716, DOI: 10.1038/s41420-017-0005-6	Cell Death Discovery 4/1	2019-10-28
2017	Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimerâ€™s Disease Research published pages: , ISSN: 2161-0460, DOI: 10.4172/2161-0460.1000400	Journal of Alzheimerâ€™s Disease & Parkinsonism 07/06	2019-10-28
2018	G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka Inhibitory interneurons in Alzheimerâ€™s disease published pages: 205-209, ISSN: 1336-0345, DOI: 10.4149/bll_2018_038	Bratislava Medical Journal 119/04	2019-10-28
2018	GaÃ«l Barthet, TomÃ s JordÃ -Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike MÃ¼ller, Christophe Mulle Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06813-x	Nature Communications 9/1	2019-10-28
2019	Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael SchÃ¶ll Propagation of tau pathology: integrating insights from post mortem and in vivo studies published pages: , ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.09.019	Biological Psychiatry	2019-10-28
2019	Thomas Vogels, Adriana-Natalia Murgoci, TomÃ¡Å¡ HromÃ¡dka Intersection of pathological tau and microglia at the synapse published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-019-0754-y	Acta Neuropathologica Communications 7/1	2019-10-28

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