Explore the words cloud of the SyDAD project. It provides you a very rough idea of what is the project "SyDAD" about.
The following table provides information about the project.
Coordinator |
KAROLINSKA INSTITUTET
Organization address contact info |
Coordinator Country | Sweden [SE] |
Total cost | 3˙846˙736 € |
EC max contribution | 3˙846˙736 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2015 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2015 |
Duration (year-month-day) | from 2015-11-01 to 2019-10-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | KAROLINSKA INSTITUTET | SE (STOCKHOLM) | coordinator | 1˙054˙637.00 |
2 | UNIVERSITE DE BORDEAUX | FR (BORDEAUX) | participant | 788˙626.00 |
3 | UNIVERSITA DEGLI STUDI DI MILANO | IT (MILANO) | participant | 774˙183.00 |
4 | DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV | DE (BONN) | participant | 747˙649.00 |
5 | JANSSEN PHARMACEUTICA NV | BE (BEERSE) | participant | 250˙560.00 |
6 | AXON NEUROSCIENCE SE | SK (BRATISLAVA) | participant | 231˙078.00 |
7 | ALZECURE DISCOVERY | SE (Huddinge) | partner | 0.00 |
8 | ALZHEIMER EUROPE | LU (LUXEMBOURG) | partner | 0.00 |
9 | ASTRAZENECA AB | SE (SODERTAELJE) | partner | 0.00 |
10 | GOETEBORGS UNIVERSITET | SE (GOETEBORG) | partner | 0.00 |
11 | SERENDIPITY INNOVATIONS AB | SE (STOCKHOLM) | partner | 0.00 |
Given an overwhelming increase of dementia costs and an aging population, there is an urgent need for finding novel therapies for Alzheimer Disease (AD). We are, however, facing a large number of failed clinical trials and a retraction of the nervous system R&D programmes from several big pharmaceutical companies. Increased collaboration between academia and the private sector is required to overcome this challenge. The “Synaptic Dysfunction in Alzheimer Disease” (SyDAD) project will significantly contribute to this approach by training a new generation of researchers with experience and full understanding of the requirements of academia, pharmaceutical companies, the clinics and the society. The research programme will focus on synaptic dysfunction, the main connection point between pathology and cognitive decline in AD. Given the complementary expertise, SyDAD will have excellent opportunities to delineate the cross-talk between different pathways underlying synaptic dysfunction in AD and to identify novel pharmaceutical targets. For future implementation of the research findings into clinical trials, a drug discovery platform will be elaborated, utilising the industrial and clinical expertise in the network. The early-stage researchers (ESRs) will be trained in this environment and provided with a mind-set of future commercial and clinical utilisation of their research findings. Apart from the innovative and collaborative approach of the research programme, the ESRs will also be provided with a training programme where cutting-edge methodology, innovation and transferable skills are key components. The trained ESRs will have excellent intersectoral and interdisciplinary career opportunities and will, together with the SyDAD partners, provide a solid ground to tackle one of the major societal challenges of our century: Finding therapies to decrease the suffering and economic burden of AD patients.
Publications | Websites, patent fillings, videos etc. | 2020-03-24 11:02:43 |
Half-time control reports and seminars by the ESRs | Documents, reports | 2020-03-24 11:02:32 |
Doctoral degrees | Documents, reports | 2020-03-24 11:02:27 |
Detailed plans for second years training and meetings | Documents, reports | 2020-03-24 11:02:43 |
Detailed plans for third years training and meetings | Documents, reports | 2020-03-24 11:02:15 |
Established website | Websites, patent fillings, videos etc. | 2019-10-01 10:07:09 |
Detailed plans for first years training and meetings | Documents, reports | 2019-10-01 10:07:09 |
ESRs recruited | Documents, reports | 2019-10-01 10:07:09 |
Public dissemination, including workshop with People living with dementia | Documents, reports | 2019-10-01 10:07:09 |
Take a look to the deliverables list in detail: detailed list of SyDAD deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà -Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2019.00273 |
Frontiers in Aging Neuroscience 11 | 2020-01-28 |
2020 |
Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration published pages: 104645, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2019.104645 |
Neurobiology of Disease 134 | 2020-01-28 |
2019 |
Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, Gaël Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease published pages: mcp.RA119.001737, ISSN: 1535-9476, DOI: 10.1074/mcp.ra119.001737 |
Molecular & Cellular Proteomics | 2020-01-28 |
2019 |
Una Smailovic, Vesna Jelic Neurophysiological Markers of Alzheimer’s Disease: Quantitative EEG Approach published pages: 37-55, ISSN: 2193-8253, DOI: 10.1007/s40120-019-00169-0 |
Neurology and Therapy 8/S2 | 2020-01-28 |
2019 |
Una Smailovic, Thomas Koenig, Erika J Laukka, Grégoria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic EEG time signature in Alzheimer´s disease: Functional brain networks falling apart published pages: 102046, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.102046 |
NeuroImage: Clinical 24 | 2020-01-28 |
2018 |
Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar Björkhem, Javier DeFelipe, Angel Cedazo-Minguez 27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons published pages: 429-446, ISSN: 1047-3211, DOI: 10.1093/cercor/bhy274 |
Cerebral Cortex 29/1 | 2020-01-28 |
2018 |
Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito Calì, Paola Pizzo, Maria Ankarcrona TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer published pages: 369-382.e6, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.12.047 |
Current Biology 28/3 | 2019-10-28 |
2019 |
Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40887-x |
Scientific Reports 9/1 | 2019-10-28 |
2019 |
Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano Multiâ€omics identify xanthine as a proâ€survival metabolite for nematodes with mitochondrial dysfunction published pages: e99558, ISSN: 0261-4189, DOI: 10.15252/embj.201899558 |
The EMBO Journal 38/6 | 2019-10-28 |
2019 |
Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena published pages: 7136-7143, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1583-5 |
Molecular Neurobiology 56/10 | 2019-10-28 |
2018 |
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-018-0605-2 |
Acta Neuropathologica Communications 6/1 | 2019-10-28 |
2018 |
Kostoula Troulinaki, Sven Büttner, Anaïs Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans published pages: , ISSN: 2058-7716, DOI: 10.1038/s41420-017-0005-6 |
Cell Death Discovery 4/1 | 2019-10-28 |
2017 |
Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research published pages: , ISSN: 2161-0460, DOI: 10.4172/2161-0460.1000400 |
Journal of Alzheimer’s Disease & Parkinsonism 07/06 | 2019-10-28 |
2018 |
G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka Inhibitory interneurons in Alzheimer’s disease published pages: 205-209, ISSN: 1336-0345, DOI: 10.4149/bll_2018_038 |
Bratislava Medical Journal 119/04 | 2019-10-28 |
2018 |
Gaël Barthet, Tomàs Jordà -Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06813-x |
Nature Communications 9/1 | 2019-10-28 |
2019 |
Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll Propagation of tau pathology: integrating insights from post mortem and in vivo studies published pages: , ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.09.019 |
Biological Psychiatry | 2019-10-28 |
2019 |
Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka Intersection of pathological tau and microglia at the synapse published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-019-0754-y |
Acta Neuropathologica Communications 7/1 | 2019-10-28 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYDAD" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "SYDAD" are provided by the European Opendata Portal: CORDIS opendata.