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CELLPLASTICITY SIGNED

New Frontiers in Cellular Reprogramming: Exploiting Cellular Plasticity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CELLPLASTICITY project word cloud

Explore the words cloud of the CELLPLASTICITY project. It provides you a very rough idea of what is the project "CELLPLASTICITY" about.

induce transient occurs ageing contribution completion reprogrammable cancer yield reprogramming gain nature regeneration made fundamental vivo background became pluripotent regard 1 mice grant insights suppressors differentiation expression diverse senescence models pluripotency origin plasticity 2012 tumour group follows mouse tool metabolism worked emphasis yamanaka cell 2 interface oct4 damage cellular basis anticipate initiation adaptive 3 contributions 2013 manipulation maladaptive frontiers lineage hypothesized tracing inducible characterization advantage lies erc microenvironment integrate de hypothesis experimental tissue chemical divided unifying

Project "CELLPLASTICITY" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA city: BARCELONA postcode: 8028 website: www.irbbarcelona.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	2˙488˙850 €
EC max contribution	2˙488˙850 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA city: BARCELONA postcode: 8028 website: www.irbbarcelona.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	2˙024˙047.00
2	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnio.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	464˙803.00

Map

Project objective

'Our research group has worked over the years at the interface between cancer and ageing, with a strong emphasis on mouse models. More recently, we became interested in cellular reprogramming because we hypothesized that understanding cellular plasticity could yield new insights into cancer and ageing. Indeed, during the previous ERC Advanced Grant, we made relevant contributions to the fields of cellular reprogramming (Nature 2013), cellular senescence (Cell 2013), cancer (Cancer Cell 2012), and ageing (Cell Metabolism 2012). Now, we take advantage of our diverse background and integrate the above processes. Our unifying hypothesis is that cellular plasticity lies at the basis of tissue regeneration (“adaptive cellular plasticity”), as well as at the origin of cancer (“maladaptive gain of cellular plasticity”) and ageing (“maladaptive loss of cellular plasticity”). A key experimental system will be our “reprogrammable mice” (with inducible expression of the four Yamanaka factors), which we regard as a tool to induce cellular plasticity in vivo. The project is divided as follows: Objective #1 – Cellular plasticity and cancer: role of tumour suppressors in in vivo de-differentiation and reprogramming / impact of transient de-differentiation on tumour initiation / lineage tracing of Oct4 to determine whether a transient pluripotent-state occurs during cancer. Objective #2 – Cellular plasticity in tissue regeneration and ageing: impact of transient de-differentiation on tissue regeneration / contribution of the damage-induced microenvironment to tissue regeneration / impact of transient de-differentiation on ageing. Objective #3: New frontiers in cellular plasticity: chemical manipulation of cellular plasticity in vivo / new states of pluripotency / characterization of in vivo induced pluripotency and its unique properties. We anticipate that the completion of this project will yield new fundamental insights into cancer, regeneration and ageing.'

Publications

List of publications.
year	authors and title	journal	last update
2017	Manuel Serrano Ageing: Tools to eliminate senescent cells published pages: 294-296, ISSN: 0028-0836, DOI: 10.1038/nature22493	Nature 545/7654	2020-02-12
2017	Izumi Horikawa, Kye-yoon Park, Kazunobu Isogaya, Yukiharu Hiyoshi, Han Li, Katsuhiro Anami, Ana I Robles, Abdul M Mondal, Kaori Fujita, Manuel Serrano, Curtis C Harris Î”133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells published pages: 1017-1028, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.48	Cell Death and Differentiation 24/6	2020-02-12
2017	Beatriz Lozano-Torres, Irene Galiana, Miguel Rovira, Eva Garrido, Selim Chaib, Andrea Bernardos, Daniel MuÃ±oz-EspÃn, Manuel Serrano, RamÃ³n MartÃnez-MÃ¡Ã±ez, FÃ©lix SancenÃ³n An OFFâ€“ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo published pages: 8808-8811, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04985	Journal of the American Chemical Society 139/26	2020-02-12
2017	Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V. Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel MuÃ±oz-EspÃn, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend, Manuel Serrano, Jiri Bartek, Vassilis G. Gorgoulis Robust, universal biomarker assay to detect senescent cells in biological specimens published pages: 192-197, ISSN: 1474-9718, DOI: 10.1111/acel.12545	Aging Cell 16/1	2020-02-12
2016	Shira Knafo, Cristina SÃ¡nchez-Puelles, Ernest Palomer, Igotz Delgado, Jonathan E Draffin, Janire Mingo, Tina Wahle, Kanwardeep Kaleka, Liping Mou, Inmaculada Pereda-Perez, Edvin Klosi, Erik B Faber, Heidi M Chapman, Laura Lozano-Montes, Ana Ortega-Molina, Lara OrdÃ³Ã±ez-GutiÃ©rrez, Francisco Wandosell, Jose ViÃ±a, Carlos G Dotti, Randy A Hall, Rafael Pulido, Nashaat Z Gerges, Andrew M Chan, Mark R Spaller, Manuel Serrano, CÃ©sar Venero, JosÃ© A Esteban PTEN recruitment controls synaptic and cognitive function in Alzheimer\'s models published pages: 443-453, ISSN: 1097-6256, DOI: 10.1038/nn.4225	Nature Neuroscience 19/3	2020-02-12
2017	Manuel Serrano Understanding Aging published pages: 1083-1085, ISSN: 0028-4793, DOI: 10.1056/NEJMcibr1615878	New England Journal of Medicine 376/11	2020-02-12
2017	Miguel Ãngel SÃ¡nchez-Luengo, Miguel Rovira, Manuel Serrano, Pablo Jose Fernandez-Marcos, Lola Martinez Analysis of the advantages of cis reporters in optimized FACS-Gal published pages: 721-729, ISSN: 1552-4922, DOI: 10.1002/cyto.a.23086	Cytometry Part A 91/7	2020-02-12
2017	Ramaswamy Kannappan, Alex Matsuda, JoÃ£o Ferreira-Martins, Eric Zhang, Giorgia Palano, Anna Czarna, Mauricio Castro Cabral-Da-Silva, Adriana Bastos-Carvalho, Fumihiro Sanada, Noriko Ide, Marcello Rota, Maria A. Blasco, Manuel Serrano, Piero Anversa, Annarosa Leri p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo published pages: 224-237, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2017.01.028	EBioMedicine 16	2020-02-12

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