#	Pagina
attuale pagina	/open-h2020/projects/198794/index.html

Opendata, web and dolomites

BetaCellTherapy SIGNED

Beta Cell Generation by Stem Cell-Derived Implants in Diabetes

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

BetaCellTherapy project word cloud

Explore the words cloud of the BetaCellTherapy project. It provides you a very rough idea of what is the project "BetaCellTherapy" about.

cells modifications efficacy auto maturation serious disease pancreatic therapeutic laboratory helps cure manufactured industry patients expert pancreases guide clinical life reactivity burden forms minds health treatment collected models improvement subcutaneous data pilot innate chronic grafts stem heavy biology examine ipsc combined shown despite metabolically implant outcome caused proof recipient depletion prepared protocols encapsulated status society search combination device markers restoration implants academic endodermal diabetes metabolic homeostatic joins immune embryonic understand basis influence es monitor clinically mass innovating source functional risks transition biologic human host progress hu indicate insulin preclinical explore pluripotent beta generate cell

Project "BetaCellTherapy" data sheet

The following table provides information about the project.

Coordinator	VRIJE UNIVERSITEIT BRUSSEL Organization address address: PLEINLAAN 2 city: BRUSSEL postcode: 1050 website: www.vub.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://www.betacelltherapy.org
Total cost	6˙800˙000 €
EC max contribution	6˙200˙000 € (91%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-single-stage_RTD
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-12-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VRIJE UNIVERSITEIT BRUSSEL VRIJE UNIVERSITEIT BRUSSEL Organization address address: PLEINLAAN 2 city: BRUSSEL postcode: 1050 website: www.vub.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSEL)	coordinator	3˙100˙000.00
2	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	1˙200˙000.00
3	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	600˙000.00
4	CENTER FOR BETA CELL THERAPY IN DIABETES CENTER FOR BETA CELL THERAPY IN DIABETES Organization address address: LAARBEEKLAAN 103 city: BRUSSEL postcode: 1090 website: www.betacelltherapy.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSEL)	participant	600˙000.00
5	VIACYTE, INC CORPORATION VIACYTE, INC CORPORATION Organization address address: GENERAL ATOMICS COURT 3550 city: SAN DIEGO CA postcode: 92121 website: www.viacyte.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (SAN DIEGO CA)	participant	600˙000.00
6	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 website: http://icm-institute.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	100˙000.00
7	NESTEC SA NESTEC SA Organization address address: EPFL INNOVATION PARK BUILDING H city: LAUSANNE postcode: 1015 website: http://www.nestleinstitutehealthsciences.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00
8	NESTEC SA NESTEC SA Organization address address: AVENUE NESTLE 55 city: VEVEY postcode: 1800 website: www.nestle.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (VEVEY)	participant	0.00

Map

Project objective

Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases have shown proof-of-principle but also the need for developing a large-scale source for therapeutic cells. Our objective is to generate a functional beta cell mass by stem cell-derived implants in diabetes patients. A combined preclinical and clinical project will search recipient and implant conditions for formation and maturation of beta cells in subcutaneous implants of device-encapsulated pancreatic endodermal cells that are derived from human embryonic stem cells (hu-ES) and manufactured for clinical studies. We collected preclinical evidence for the therapeutic potential of this implant from comparison with clinically used human beta cell grafts. State-of-the art methods and markers have been developed to investigate the biology of implants and to monitor host immune and innate reactivity. This approach helps understand the basis for metabolic outcome and identify targets for improvement. Pilot studies examine the influence of the (auto)immune status of the patients. Data will determine transition to clinical efficacy studies, or indicate the need for further laboratory development. Implants in preclinical models will guide modifications in clinical protocols, and explore the biologic properties of grafts derived from human induced pluripotent stem cell (iPSc) as can also be prepared from diabetes patients. Our consortium joins innovating cells, methods, markers and minds in a unique combination of expert clinical, academic and industry activities that need each other to make progress in an ambitious program.

Deliverables

List of deliverables.
Human beta cell grafts with QC data for start transplants in subgroup of type 1 diabetes recipients of VCTM implant	Demonstrators, pilots, prototypes	2020-03-11 13:03:37
Human beta cell preparations with QC data for comparative assessment of human iPS-derived implants in preclinical model and their use in screening assay	Demonstrators, pilots, prototypes	2020-03-11 13:03:57
Production of biodegradable microparticles for local release of VEGF, NGF and exenatide	Demonstrators, pilots, prototypes	2019-09-13 11:09:19
Time-table for public information on program	Other	2019-09-13 11:09:19
Communication network operational	Other	2019-09-13 11:09:19

Take a look to the deliverables list in detail: detailed list of BetaCellTherapy deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Else M. Balke, Eric V. Balti, Bart Van der Auwera, Ilse Weets, Olivier Costa, Simke Demeester, Pascale Abrams, Kristina Casteels, Marina Coeckelberghs, Sylvie Tenoutasse, Bart Keymeulen, Daniel G. Pipeleers, Frans K. Gorus Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A24 and -B18 Is Restricted to Multiple Islet Autoantibodyâ€“Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles published pages: 1076-1083, ISSN: 0149-5992, DOI: 10.2337/dc17-2462	Diabetes Care 41/5	2019-10-29
2018	Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi Pluripotent stem cell replacement approaches to treat type 1 diabetes published pages: 20-26, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.07.007	Current Opinion in Pharmacology 43	2019-10-09
2018	Sarah Roels, Olivier R Costa, Sarah A Tersey, Geert StangÃ©, Dieter De Smet, Eric V Balti, Pieter Gillard, Bart Keymeulen, Zhidong Ling, Daniel G Pipeleers, Frans K Gorus, Raghavendra G Mirmira, Geert A Martens Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D published pages: 451-460, ISSN: 0021-972X, DOI: 10.1210/jc.2017-02520	The Journal of Clinical Endocrinology & Metabolism 104/2	2019-10-09
2019	Sarah Akbib, Jordy Stichelmans, Geert StangÃ©, Zhidong Ling, Zerihun Assefa, Karine H. Hellemans Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially published pages: e0212210, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212210	PLOS ONE 14/2	2019-10-09
2018	Olivier R. Costa, Katrijn Verhaeghen, Sarah Roels, Geert StangÃ©, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65 published pages: e0193670, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193670	PLOS ONE 13/3	2019-10-09
2018	Else M. Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J. Van der Auwera, Zhidong Ling, Bart O. Roep, DaniÃ«l G. Pipeleers, Bart Keymeulen, Frans K. Gorus *SLC30A8 polymorphism and BMI complement HLA-A24 as risk factors for poor graft function in islet allograft recipients** published pages: 1623-1632, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4609-z	Diabetologia 61/7	2019-10-09
2015	Zhidong Ling, Pieter De Pauw, Daniel Jacobs-Tulleneers-Thevissen, Rui Mao, Pieter Gillard, Christiane S. Hampe, Geert A. Martens, Peter In\'t Veld, Ã…ke Lernmark, Bart Keymeulen, Frans Gorus, Daniel Pipeleers Plasma GAD65, a Marker for Early Î²-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients published pages: 2314-2321, ISSN: 0021-972X, DOI: 10.1210/jc.2015-1216	The Journal of Clinical Endocrinology & Metabolism 100/6	2019-10-09
2018	Ines De Mesmaeker, Thomas Robert, Krista G. Suenens, Geert M. StangÃ©, Freya Van Hulle, Zhidong Ling, Peter Tomme, Daniel Jacobs-Tulleneers-Thevissen, Bart Keymeulen, Daniel G. Pipeleers Increase Functional Î²-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells published pages: 2640-2649, ISSN: 0012-1797, DOI: 10.2337/db18-0709	Diabetes 67/12	2019-10-09
2015	Silvia Pellegrini, Federica Ungaro, Alessia Mercalli, Raffaella Melzi, Guido Sebastiani, Francesco Dotta, Vania Broccoli, Lorenzo Piemonti, Valeria Sordi Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo published pages: 1025-1035, ISSN: 0940-5429, DOI: 10.1007/s00592-015-0726-z	Acta Diabetologica 52/6	2019-09-13
2016	Daniel Pipeleers, Thomas Robert, Ines De Mesmaeker, Zhidong Ling Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as Î²-Cell Replacement in Type 1 Diabetes published pages: 1338-1344, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0187	STEM CELLS Translational Medicine 5/10	2019-09-13
2016	Cornelis R. van der Torren, Annemarie A. Verrijn Stuart, DaHae Lee, Jenny Meerding, Ursule van de Velde, Daniel Pipeleers, Pieter Gillard, Bart Keymeulen, Wilco de Jager, Bart O. Roep Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes published pages: e0146649, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0146649	PLOS ONE 11/1	2019-09-13
2017	Cornelis R. van der Torren, Arnaud Zaldumbide, Gaby Duinkerken, Simone H. Brand-Schaaf, Mark Peakman, Geert StangÃ©, Laura Martinson, Evert Kroon, Eugene P. Brandon, Daniel Pipeleers, Bart O. Roep Immunogenicity of human embryonic stem cell-derived beta cells published pages: 126-133, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4125-y	Diabetologia 60/1	2019-09-13
2016	Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, DaniÃ«l Pipeleers, Ilse Weets, Frans K. Gorus Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio published pages: e0166702, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0166702	PLOS ONE 11/12	2019-09-13
2017	Guido Sebastiani, Marco Valentini, Giuseppina Emanuela Grieco, Giuliana Ventriglia, Laura Nigi, Francesca Mancarella, Silvia Pellegrini, Gianvito Martino, Valeria Sordi, Lorenzo Piemonti, Francesco Dotta MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells published pages: 265-281, ISSN: 0940-5429, DOI: 10.1007/s00592-016-0955-9	Acta Diabetologica 54/3	2019-09-13
2017	Maria J L Kracht, Menno van Lummel, Tatjana Nikolic, Antoinette M Joosten, Sandra Laban, Arno R van der Slik, Peter A van Veelen, FranÃ§oise Carlotti, Eelco J P de Koning, Rob C Hoeben, Arnaud Zaldumbide, Bart O Roep Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes published pages: 501-507, ISSN: 1078-8956, DOI: 10.1038/nm.4289	Nature Medicine 23/4	2019-09-13
2015	GregoryÂ L. Szot, Mahesh Yadav, Jiena Lang, Evert Kroon, Justin Kerr, Kuniko Kadoya, EugeneÂ P. Brandon, EmmanuelÂ E. Baetge, HÃ©lÃ¨ne Bour-Jordan, JeffreyÂ A. Bluestone Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic StemÂ Cell-Derived Pancreatic Endoderm published pages: 148-157, ISSN: 1934-5909, DOI: 10.1016/j.stem.2014.12.001	Cell Stem Cell 16/2	2019-09-13
2015	Olivier R. Costa, Geert StangÃ©, Katrijn Verhaeghen, Benedicte Brackeva, Ellen Nonneman, Christiane S. Hampe, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic Î²-Cell Death published pages: 4755-4760, ISSN: 0013-7227, DOI: 10.1210/en.2015-1636	Endocrinology 156/12	2019-09-13
2017	Frans K. Gorus, Eric V. Balti, Anissa Messaaoui, Simke Demeester, Annelien Van Dalem, Olivier Costa, Harry Dorchy, Chantal Mathieu, Luc Van Gaal, Bart Keymeulen, DaniÃ«l G. Pipeleers, Ilse Weets Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes published pages: 1065-1072, ISSN: 0149-5992, DOI: 10.2337/dc16-2228	Diabetes Care 40/8	2019-09-13
2016	Zerihun Assefa, Sarah Akbib, Astrid Lavens, Geert StangÃ©, Zhidong Ling, Karine H. Hellemans, Daniel Pipeleers Direct effect of glucocorticoids on glucose-activated adult rat Î²-cells increases their cell number and their functional mass for transplantation published pages: E698-E705, ISSN: 0193-1849, DOI: 10.1152/ajpendo.00070.2016	American Journal of Physiology - Endocrinology And Metabolism 311/4	2019-09-13
2018	Thomas Robert, Ines De Mesmaeker, Geert M. StangÃ©, Krista G. Suenens, Zhidong Ling, Evert J. Kroon, Daniel G. Pipeleers Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control published pages: 739-750, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.040	Stem Cell Reports 10/3	2019-09-13
2016	Simke Demeester, Else M. Balke, Bart J. Van der Auwera, Pieter Gillard, Robert Hilbrands, DaHae Lee, Ursule Van de Velde, Zhidong Ling, Bart O. Roep, Daniel G. Pipeleers, Frans K. Gorus, Bart Keymeulen *HLA-A24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft** published pages: 1060-1064, ISSN: 0149-5992, DOI: 10.2337/dc15-2768	Diabetes Care 39/6	2019-09-13
2017	Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, DaniÃ«l Pipeleers, Ilse Weets, Frans K. Gorus Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio published pages: e0179108, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179108	PLOS ONE 12/6	2019-09-13
2017	Elisa Cantarelli, Antonio Citro, Silvia Pellegrini, Alessia Mercalli, Raffaella Melzi, Erica Dugnani, Tatiana Jofra, Georgia Fousteri, Anna Mondino, Lorenzo Piemonti Transplant Site Influences the Immune Response After Islet Transplantation published pages: 1046-1055, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001462	Transplantation 101/5	2019-09-13
2018	Silvia Pellegrini, Fabio Manenti, Raniero Chimienti, Rita Nano, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Philippe Ravassard, Lorenzo Piemonti, Valeria Sordi Differentiation of Sendai Virus-Reprogrammed iPSC into Î² Cells, Compared with Human Pancreatic Islets and Immortalized Î² Cell Line published pages: 1548-1560, ISSN: 0963-6897, DOI: 10.1177/0963689718798564	Cell Transplantation 27/10	2019-09-13
2017	A. Citro, E. Cantarelli, S. Pellegrini, E. Dugnani, L. Piemonti Antiinflammatory strategies in intrahepatic islet transplantation published pages: 1, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001925	Transplantation	2019-09-13
2017	Daniel Pipeleers, Ines De Mesmaeker, Thomas Robert, Freya Van Hulle Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-017-0925-9	Current Diabetes Reports 17/10	2019-09-13
2017	Valeria Sordi, Silvia Pellegrini, Lorenzo Piemonti Immunological Issues After Stem Cell-Based Î² Cell Replacement published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-017-0901-4	Current Diabetes Reports 17/9	2019-09-13
2017	V. Sordi, S. Pellegrini, M. Krampera, P. Marchetti, A. Pessina, G. Ciardelli, G. Fadini, C. Pintus, G. PantÃ¨, L. Piemonti Stem cells to restore insulin production and cure diabetes published pages: 583-600, ISSN: 0939-4753, DOI: 10.1016/j.numecd.2017.02.004	Nutrition, Metabolism and Cardiovascular Diseases 27/7	2019-09-13
2018	Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi The potential and challenges of alternative sources of Î² cells for the cure of type 1 diabetes published pages: R114-R125, ISSN: 2049-3614, DOI: 10.1530/EC-18-0012	Endocrine Connections 7/3	2019-09-13
2017	Dae Hae Lee, Bart Keymeulen, Robert Hilbrands, Zhidong Ling, Ursule Van de Velde, Daniel Jacobs-Tulleneers-Thevissen, Geert Maleux, Bruno Lapauw, Laurent Crenier, Christophe De Block, Chantal Mathieu, Daniel Pipeleers, Pieter Gillard Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression published pages: 2218-2227, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001543	Transplantation 101/9	2019-09-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BETACELLTHERAPY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BETACELLTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.3.)

GACD (2019)

Global Alliance for Chronic Diseases Secretariat

LEGACy (2019)

CeLac and European consortium for a personalized medicine approach to Gastric Cancer

DIAdIC (2019)

Evaluation of Dyadic Psychoeducational Interventions for People with Advanced Cancer and their Informal Caregivers (DIAdIC): An international randomized controlled trial