Explore the words cloud of the MOZART project. It provides you a very rough idea of what is the project "MOZART" about.
The following table provides information about the project.
Coordinator |
POLITECNICO DI TORINO
Organization address contact info |
Coordinator Country | Italy [IT] |
Project website | http://www.mozartproject.eu/ |
Total cost | 4˙651˙228 € |
EC max contribution | 4˙651˙228 € (100%) |
Programme |
1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies) 2. H2020-EU.2.1.2.5. (Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment) 3. H2020-EU.2.1.2.3. (Developing the societal dimension of nanotechnology) |
Code Call | H2020-NMP-PILOTS-2015 |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-11-01 to 2019-10-31 |
Take a look of project's partnership.
# | ||||
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1 | POLITECNICO DI TORINO | IT (TORINO) | coordinator | 925˙000.00 |
2 | CHARITE - UNIVERSITAETSMEDIZIN BERLIN | DE (BERLIN) | participant | 709˙000.00 |
3 | ASHLAND SPECIALTIES IRELAND LIMITED | IE (Dublin) | participant | 536˙875.00 |
4 | THE UNIVERSITY OF SHEFFIELD | UK (SHEFFIELD) | participant | 500˙930.00 |
5 | FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG | DE (ERLANGEN) | participant | 381˙975.00 |
6 | "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" | EL (AGIA PARASKEVI) | participant | 369˙300.00 |
7 | NOBIL BIO RICERCHE SRL | IT (CONCESIO) | participant | 322˙500.00 |
8 | NANOLITH SVERIGE AB | SE (BROMMA) | participant | 321˙898.00 |
9 | UNIVERSIDAD COMPLUTENSE DE MADRID | ES (MADRID) | participant | 265˙000.00 |
10 | DELSITECH OY | FI (TURKU) | participant | 225˙000.00 |
11 | CELLOGIC GMBH | DE (BERLIN) | participant | 93˙750.00 |
The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag, Li, Cu2, Sr2, Ce3, B3) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.
year | authors and title | journal | last update |
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2019 |
Elisa Torre, Dimitra Giasafaki, Theodore Steriotis, Clara Cassinelli, Marco Morra, Sonia Fiorilli, Chiara Vitale-Brovarone, Georgia Charalambopoulou, Giorgio Iviglia Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context published pages: 10147-10164, ISSN: 1178-2013, DOI: 10.2147/ijn.s234393 |
International Journal of Nanomedicine Volume 14 | 2020-04-06 |
2019 |
M. Boffito, C. Pontremoli, S. Fiorilli, R. Laurano, G. Ciardelli, C. Vitale-Brovarone Injectable thermosensitive polyurethane hydrogels for sustained co-delivery of functional ions and drugs published pages: , ISSN: 1999-4923, DOI: |
Pharmaceutics | 2020-04-06 |
2017 |
Gisbert-Garzarán M, Manzano M, Vallet-Regà M. Self-immolative chemistry in nanomedicine. published pages: , ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.098 |
Chemical Engineering Journal | 2020-04-06 |
2019 |
Kai Zheng, Preethi Balasubramanian, Thomas E. Paterson, Rene Stein, Sheila MacNeil,
Sonia Fiorilli, Chiara Vitale-Brovarone, Joanna Shepherd, Aldo R. Boccaccini Ag modified mesoporous bioactive glass nanoparticles for enhancedantibacterial activity in 3D infected skin model published pages: , ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.109764 |
Material Sciences & Engineering C | 2020-04-06 |
2019 |
Anthony J. Bullock, Marcela Garcia, Joanna Shepherd, Ihtesham Rehman &
MacNeil Sheila Bacteria induced pH changes in tissue-engineered human skin detected noninvasively using Raman confocal spectroscop published pages: , ISSN: 0570-4928, DOI: |
Applied Spectroscopy Reviews | 2020-04-06 |
2018 |
Sonia Fiorilli, Giulia Molino, Carlotta Pontremoli, Giorgio Iviglia, Elisa Torre, Clara Cassinelli, Marco Morra, Chiara Vitale-Brovarone The Incorporation of Strontium to Improve Bone-Regeneration Ability of Mesoporous Bioactive Glasses published pages: 678, ISSN: 1996-1944, DOI: 10.3390/ma11050678 |
Materials 11/5 | 2020-04-06 |
2017 |
Taimoor H. Qazi, Shahzad Hafeez, Jochen Schmidt, Georg N. Duda, Aldo R. Boccaccini, Evi Lippens Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior published pages: 2772-2782, ISSN: 1549-3296, DOI: 10.1002/jbm.a.36131 |
Journal of Biomedical Materials Research Part A 105/10 | 2020-04-06 |
2017 |
H. Schell, G. N. Duda, A. Peters, S. Tsitsilonis, K. A. Johnson, K. Schmidt-Bleek The haematoma and its role in bone healing published pages: , ISSN: 2197-1153, DOI: 10.1186/s40634-017-0079-3 |
Journal of Experimental Orthopaedics 4/1 | 2020-04-06 |
2017 |
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-RegÃ, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.012 |
Acta Biomaterialia | 2020-04-06 |
2017 |
M. Gisbert-Garzaran, D. Lozano, M. Vallet-RegÃ, M. Manzano Self-immolative polymers as novel pH-responsive gate keepers for drug delivery published pages: 132-136, ISSN: 2046-2069, DOI: 10.1039/C6RA26771H |
RSC Adv. 7/1 | 2020-04-06 |
2017 |
Francesco Baino, Sonia Fiorilli, Chiara Vitale-Brovarone Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review published pages: 15, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010015 |
Bioengineering 4/1 | 2020-04-06 |
2018 |
C. Pontremoli, M. Boffito, S. Fiorilli, R. Laurano, A. Torchio, A. Bari, C. Tonda-Turo, G. Ciardelli, C. Vitale-Brovarone Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses published pages: 103-113, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.073 |
Chemical Engineering Journal 340 | 2020-04-06 |
2017 |
Miguel Gisbert-Garzarán, Miguel Manzano, MarÃa Vallet-Regà pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery published pages: 3, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010003 |
Bioengineering 4/1 | 2020-04-06 |
2017 |
Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, MarÃa Vallet-Regà Tuning mesoporous silica dissolution in physiological environments: a review published pages: , ISSN: 0022-2461, DOI: 10.1007/s10853-017-0787-1 |
Journal of Materials Science | 2020-04-06 |
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