Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. endonaut

EndoNaut

EndoNaut Delivery Platform

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EndoNaut project word cloud

Explore the words cloud of the EndoNaut project. It provides you a very rough idea of what is the project "EndoNaut" about.

erc    reagents    core    platform    screening    grant    water    drugs    therapies    allowed    viability    nanotechnology    encapsulate    biological    helped    yearly    prnewswire    surprising    companies    tools    compounds    entities    engineer    hydrophobic    pmpc    di    ones    carriers    contrast    form    polymersomes    reagent    hydrophilic    mevic    science    libraries    life    endonaut    usd    nanoscopic    copolymer    intracellular    maintaining    combination    ethyl    isopropylamino    prime    chemical    billions    perform    consists    collaborating    advent    assembly    cell    first    few    revenue    ph    commercial    stg    translation    polymeric    pharmaceutical    whilst    award    physical    market    functions    molecular    opportunity    vesicles    powerful    agents    laboratory    methacrylate    metabolic    molecules    imaging    diblock    poly    option    sensitive    macromolecules    throughput    endosomal    translating    company    dyes    9    pdpa    grow    commercialisation    world    predicted    generating    encapsulation    phosphorylcholine    methacryloyloxy   

Project "EndoNaut" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 149˙929 €
 EC max contribution 149˙929 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 149˙929.00

Map

 Project objective

Translating intracellular delivery to the market The advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level. In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners. There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules. The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market.

 Publications

year authors and title journal last update
List of publications.
2017 Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia
Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing
published pages: e1700362, ISSN: 2375-2548, DOI: 10.1126/sciadv.1700362 		Science Advances 3/8 2019-07-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ENDONAUT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ENDONAUT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More