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EndoNaut

EndoNaut Delivery Platform

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EndoNaut project word cloud

Explore the words cloud of the EndoNaut project. It provides you a very rough idea of what is the project "EndoNaut" about.

phosphorylcholine    water    endosomal    engineer    functions    company    prnewswire    billions    consists    erc    hydrophobic    whilst    stg    entities    physical    ph    pharmaceutical    drugs    assembly    dyes    copolymer    polymeric    ones    biological    vesicles    cell    di    polymersomes    helped    compounds    metabolic    methacrylate    encapsulate    poly    commercialisation    usd    tools    intracellular    option    mevic    generating    encapsulation    pmpc    therapies    life    agents    sensitive    grant    reagents    world    libraries    carriers    powerful    commercial    perform    core    throughput    contrast    allowed    revenue    platform    opportunity    laboratory    imaging    science    macromolecules    chemical    reagent    award    endonaut    companies    translating    market    combination    screening    predicted    prime    hydrophilic    yearly    few    form    collaborating    nanoscopic    surprising    molecules    viability    translation    grow    9    molecular    diblock    nanotechnology    advent    pdpa    first    ethyl    methacryloyloxy    isopropylamino    maintaining   

Project "EndoNaut" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 149˙929 €
 EC max contribution 149˙929 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 149˙929.00

Map

 Project objective

Translating intracellular delivery to the market The advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level. In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners. There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules. The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market.

 Publications

year authors and title journal last update
List of publications.
2017 Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia
Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing
published pages: e1700362, ISSN: 2375-2548, DOI: 10.1126/sciadv.1700362 		Science Advances 3/8 2019-07-26

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The information about "ENDONAUT" are provided by the European Opendata Portal: CORDIS opendata.

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