THYRAGE SIGNED
Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities
Total Cost €
0EC-Contrib. €
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Project "THYRAGE" data sheet
The following table provides information about the project.
| Coordinator |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | http://www.thyrage.eu |
| Total cost | 6˙000˙001 € |
| EC max contribution | 6˙000˙000 € (100%) |
| Programme |
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease) |
| Code Call | H2020-PHC-2015-two-stage |
| Funding Scheme | RIA |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | coordinator | 1˙680˙410.00 |
| 2 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | participant | 1˙410˙151.00 |
| 3 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | participant | 799˙083.00 |
| 4 | UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II | IT (NAPOLI) | participant | 758˙500.00 |
| 5 | INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES | HU (Budapest) | participant | 749˙980.00 |
| 6 | PEPSCAN THERAPEUTICS BV | NL (LELYSTAD) | participant | 601˙875.00 |
Map
Project objective
We hypothesize that inappropriate thyroid hormone action in target cells is a common mechanism underlying susceptibility to age-related degenerative diseases and co-morbidities. Although regulation of systemic thyroid status is well understood and underpins treatment of common thyroid disease, it is only in the last decade that the importance of local regulation of thyroid hormone action in tissue development, homeostasis and repair has been identified. During evolution, this complex temporal and cell-specific regulation has been optimized for development and reproductive fitness but NOT for ageing. Humans with their exceptional longevity are thus exposed to a prolonged period of suboptimal local thyroid hormone action. Consistent with this, thyroid status is a continuous variable within the population that is related to fracture risk, muscle mass and cognitive decline. Moreover, in healthy longevity thyroid status is characterized by thyroid stimulating hormone in the upper half of the reference range. In these studies, we will determine how local regulation of thyroid hormone action controls tissue homeostasis and repair, whilst its dysregulation is a common mechanism underlying chronic disease development during ageing. We focus on osteoporosis, osteoarthritis, neurodegeneration and sarcopenia as paradigm age-related, degenerative disorders. Using cutting-edge technology, we will (i) identify thyroid hormone dependent biomarkers for disease susceptibility in bone, cartilage, central nervous system and skeletal muscle, (ii) manipulate cell-specific thyroid hormone action in these tissues and (iii) develop cell-type specific modulators of thyroid hormone action. THYRAGE integrates cross-disciplinary expertise from clinical and basic scientists, endocrinologists, neuroscientists, gerontologists, and industry-based peptide scientists. These studies will identify and validate novel strategies for prevention and treatment of chronic age-related degenerative disease.
Deliverables
| Final plan for dissemination and exploitation of the project’s results | Documents, reports | 2019-05-30 19:01:01 |
| Establishment of the THYRAGE consortium website | Websites, patent fillings, videos etc. | 2019-05-30 19:01:05 |
| Establishment of external THYRAGE web site | Websites, patent fillings, videos etc. | 2019-05-30 19:01:03 |
Take a look to the deliverables list in detail: detailed list of THYRAGE deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Evie van der Spoel, Jungyeon Choi, Ferdinand Roelfsema, Saskia le Cessie, Diana van Heemst, Olaf M. Dekkers Comparing Methods for Measurement Error Detection in Serial 24-h Hormonal Data published pages: 347-363, ISSN: 0748-7304, DOI: 10.1177/0748730419850917 |
Journal of Biological Rhythms 34/4 | 2020-02-13 |
| 2019 |
Evie van der Spoel, Nicolien A. van Vliet, Diana van Heemst Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance published pages: 100964, ISSN: 1568-1637, DOI: 10.1016/j.arr.2019.100964 |
Ageing Research Reviews 56 | 2020-02-13 |
| 2019 |
Jeanâ€David Gothié, Pieter Vancamp, Barbara Demeneix, Sylvie Remaud Thyroid hormone regulation of neural stem cell fate: From development to ageing published pages: , ISSN: 1748-1708, DOI: 10.1111/apha.13316 |
Acta Physiologica 228/1 | 2020-02-13 |
| 2019 |
Serena Sagliocchi, Annunziata Gaetana Cicatiello, Emery Di Cicco, Raffaele Ambrosio, Caterina Miro, Daniela Di Girolamo, Annarita Nappi, Giuseppina Mancino, Maria Angela De Stefano, Cristina Luongo, Maddalena Raia, Ashley N. Ogawa-Wong, Ann Marie Zavacki, Simona Paladino, Domenico Salvatore, Monica Dentice The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress published pages: 101228, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101228 |
Redox Biology 24 | 2020-02-13 |
| 2019 |
Caterina Miro, Emery Di Cicco, Raffaele Ambrosio, Giuseppina Mancino, Daniela Di Girolamo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Maria Angela De Stefano, Cristina Luongo, Dario Antonini, Feliciano Visconte, Silvia Varricchio, Gennaro Ilardi, Luigi Del Vecchio, Stefania Staibano, Anita Boelen, Cedric Blanpain, Caterina Missero, Domenico Salvatore, Monica Dentice Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13140-2 |
Nature Communications 10/1 | 2020-02-13 |
| 2019 |
Pieter Vancamp, Jean-David Gothié, Cristina Luongo, Anthony Sébillot, Karine Le Blay, Lucile Butruille, Maurice Pagnin, Samantha J. Richardson, Barbara A. Demeneix, Sylvie Remaud Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-56156-w |
Scientific Reports 9/1 | 2020-02-13 |
| 2019 |
Victoria D. Leitch, Mary Jane Brassill, Sofia Rahman, Natalie C. Butterfield, Pattara Ma, John G. Logan, Alan Boyde, Holly Evans, Peter I. Croucher, Rachel L. Batterham, Graham R. Williams, J.H. Duncan Bassett PYY is a negative regulator of bone mass and strength published pages: 427-435, ISSN: 8756-3282, DOI: 10.1016/j.bone.2019.07.011 |
Bone 127 | 2020-02-13 |
| 2017 |
Remaud , Sylvie; Ortiz , Fernando ,; Perret-Jeanneret , Marine; Aigrot , Marie-Stéphane; Gothié , Jean-David; Fekete , Csaba; Kvárta-Papp , Zsuzsanna; Gereben , Balázs; Langui , Dominique; Lubetzki , Catherine; Angulo , Maria ,; Zalc , Bernard; Demeneix , Barbara Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.29996.001 |
\"eLife, eLife Sciences Publication, 2017, 6, pp.e29996. 〈10.7554/eLife.29996.001〉\" 1 | 2019-03-18 |
| 2018 |
G. R. Williams, J. H. D. Bassett Thyroid diseases and bone health published pages: 99-109, ISSN: 1720-8386, DOI: 10.1007/s40618-017-0753-4 |
Journal of Endocrinological Investigation 41/1 | 2019-03-18 |
| 2017 |
Nicolien A. van Vliet, Evie van der Spoel, Marian Beekman, P. Eline Slagboom, Gerard Jan Blauw, Jacobijn Gussekloo, Rudi G.J. Westendorp, Diana van Heemst Thyroid status and mortality in nonagenarians from long-lived families and the general population published pages: 2223-2234, ISSN: 1945-4589, DOI: 10.18632/aging.101310 |
Aging 9/10 | 2019-03-18 |
| 2017 |
J.D. Gothié, A. Sébillot, C. Luongo, M. Legendre, C. Nguyen Van, K. Le Blay, M. Perret-Jeanneret, S. Remaud, B.A. Demeneix Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism published pages: 1551-1561, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.08.003 |
Molecular Metabolism 6/11 | 2019-03-18 |
| 2019 |
Evie van der Spoel, Nicole Oei, Ricardo Cachucho, Ferdinand Roelfsema, Jimmy F.P. Berbée, Gerard J. Blauw, Hanno Pijl, Natasha M. Appelman-Dijkstra, Diana van Heemst The 24-hour serum profiles of bone markers in healthy older men and women published pages: 61-69, ISSN: 8756-3282, DOI: 10.1016/j.bone.2018.10.002 |
Bone 120 | 2019-03-18 |
| 2018 |
Nicolien A van Vliet, Raymond Noordam, Jan B van Klinken, Rudi GJ Westendorp, JH Duncan Bassett, Graham R Williams, Diana van Heemst Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study published pages: 1318-1325, ISSN: 0884-0431, DOI: 10.1002/jbmr.3426 |
Journal of Bone and Mineral Research 33/7 | 2019-03-18 |
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