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LUCA SIGNED

Laser and Ultrasound Co-Analyzer for thyroid nodules

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LUCA project word cloud

Explore the words cloud of the LUCA project. It provides you a very rough idea of what is the project "LUCA" about.

near euros positive probe diffuse 15 fnab fails false leads socio tc directed screening synergetic enabled procedure disciplinary acquisition function occurs thyroidectomies photonic diminishing infrared endocrinologists 5 joins concentrated 1 engineers limited shows point ultrasonics radiologists exclude palpable nodules modality implies comorbidities specificity spectroscopy women care cover components ultrasound biopsy resolved trans 19 trs diagnostic optical industry pathology fine morphology unnecessary participate surgeries hypothesize industrial device sensitivity needle action composition physicists combines hemodynamic aspiration millions followed data exploited thyroid chain photonics sub experts correlation men economic cancer time first suspicious neck savings tn medical tissue dcs 76 prevalence modal

Project "LUCA" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.luca-project.eu/
Total cost	3˙999˙334 €
EC max contribution	3˙628˙845 € (91%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2015
Funding Scheme	IA
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2020-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Castelldefels)	coordinator	1˙048˙730.00
2	POLITECNICO DI MILANO POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	689˙700.00
3	HEMOPHOTONICS SL HEMOPHOTONICS SL Organization address address: AVENIDA CARL FRIEDRICH GAUSS 3 OFICINA 346 MEDITERRANEAN TECHNOLOGY PARK city: CASTELLDEFELS postcode: 8860 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CASTELLDEFELS)	participant	402˙299.00
4	EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Organization address address: NEUTORGASSE 9/2 city: WIEN postcode: 1010 website: www.eibir.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	375˙000.00
5	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	353˙763.00
6	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	297˙178.00
7	IMV IMAGING FRANCE IMV IMAGING FRANCE Organization address address: 126 BOULEVARD DE LA REPUBLIQUE city: ANGOULEME postcode: 16000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ANGOULEME)	participant	273˙542.00
8	VERMON SA VERMON SA Organization address address: RUE GENERAL RENAULT 180 city: TOURS postcode: 37000 website: www.vermon.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOURS)	participant	188˙630.00

Map

Project objective

This is a trans-disciplinary project that joins endocrinologists (“end-users”), radiologists (“end-users”), physicists who are experts in medical photonics, engineers who are experts in photonics and ultrasonics and the industry to work towards a concentrated goal - to produce a novel, point-of-care, low-cost, screening device that combines two photonics systems (near-infrared diffuse correlation spectroscopy (DCS) and time-resolved spectroscopy (TRS)) with a multi-modal ultrasound (US) system and a probe that enables multi-modal data acquisition for the screening of thyroid nodules (TN) for thyroid cancer (TC). TN are a common pathology having a prevalence of palpable nodules around 5% in women and 1% in men, that increases to 19-76% with the use of neck US. In screening thyroid nodules, to exclude thyroid cancer which occurs in 5-15% of TN, the first step is the US followed by fine needle aspiration biopsy (FNAB) of suspicious nodules. The sensitivity and specificity of this process in thyroid cancer are limited, with a large number of non-diagnostic and false positive results that lead to unnecessary surgeries. A reduction in the number of surgeries with a point-of-care diagnostic procedure would have an important socio-economic impact, diminishing the number of thyroidectomies and the associated comorbidities. This implies savings of millions of euros per year. Evidence shows that multi-modal approaches that include hemodynamic information leads to better specificity while each modality on its own fails. We hypothesize that a new optical-ultrasound probe and integrated system enabled by the development of novel, key enabling photonic components and sub-systems to provide synergetic information on tissue morphology, composition and function will have a large impact in this field. Our action is directed by end-users who participate in the proposal and will be exploited by the industrial partners who cover the whole value-chain.

Deliverables

List of deliverables.
Communication kit update	Documents, reports	2020-02-28 09:35:32
Report on the dissemination activity Y2	Documents, reports	2020-02-28 09:35:32
Fully functional LUCA system	Demonstrators, pilots, prototypes	2020-02-28 09:35:32
Report on the dissemination activity Y3	Documents, reports	2020-02-28 09:35:32
Data Management Plan_new	Open Research Data Pilot	2020-02-28 09:35:32
Approval by ethical committees	Documents, reports	2020-02-28 09:35:32
Project web site	Websites, patent fillings, videos etc.	2020-02-28 09:35:31
Provision of a optical-ultrasound phantom kit	Demonstrators, pilots, prototypes	2020-02-28 09:35:30
Dissemination material	Websites, patent fillings, videos etc.	2020-02-28 09:35:30
Project management and quality assurance plan	Documents, reports	2020-02-28 09:35:30
Project Presentation	Documents, reports	2020-02-28 09:35:31
Dissemination and communication plan	Documents, reports	2020-02-28 09:35:31
Data Management Plan	Documents, reports	2020-02-28 09:35:32
Report on the dissemination activity Y1	Documents, reports	2020-02-28 09:35:31
Video	Websites, patent fillings, videos etc.	2020-02-28 09:35:31

Take a look to the deliverables list in detail: detailed list of LUCA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Marco Renna, Mauro Buttafava, Anurag Behera, Marta Zanoletti, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Alberto Tosi Eight-Wavelength, Dual Detection Channel Instrument for Near-Infrared Time-Resolved Diffuse Optical Spectroscopy published pages: 1-11, ISSN: 1077-260X, DOI: 10.1109/jstqe.2018.2863570	IEEE Journal of Selected Topics in Quantum Electronics 25/1	2020-02-28
2018	Lorenzo Cortese, Giuseppe Lo Presti, Marco Pagliazzi, Davide Contini, Alberto Dalla Mora, Antonio Pifferi, Sanathana Konugolu Venkata Sekar, Lorenzo Spinelli, Paola Taroni, Marta Zanoletti, Udo M. Weigel, Sixte de Fraguier, An Nguyen-Dihn, Bogdan Rosinski, Turgut Durduran Liquid phantoms for near-infrared and diffuse correlation spectroscopies with tunable optical and dynamic properties published pages: 2068, ISSN: 2156-7085, DOI: 10.1364/BOE.9.002068	Biomedical Optics Express 9/5	2020-02-28
2018	Stanislaw Wojtkiewicz, Turgut Durduran, Hamid Dehghani Time-resolved near infrared light propagation using frequency domain superposition published pages: 41, ISSN: 2156-7085, DOI: 10.1364/boe.9.000041	Biomedical Optics Express 9/1	2020-02-28
2018	Sanathana Konugolu Venkata Sekar, Andrea Farina, Alberto Dalla Mora, Claus Lindner, Marco Pagliazzi, Mireia Mora, Gloria Aranda, Hamid Dehghani, Turgut Durduran, Paola Taroni, Antonio Pifferi Broadband (550â€“1350â€‰nm) diffuse optical characterization of thyroid chromophores published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27684-8	Scientific Reports 8/1	2020-02-28
2017	Mauro Buttafava, Edoardo Martinenghi, Davide Tamborini, Davide Contini, Alberto Dalla Mora, Marco Renna, Alessandro Torricelli, Antonio Pifferi, Franco Zappa, Alberto Tosi A Compact Two-Wavelength Time-Domain NIRS System Based on SiPM and Pulsed Diode Lasers published pages: 1-14, ISSN: 1943-0655, DOI: 10.1109/JPHOT.2016.2632061	IEEE Photonics Journal 9/1	2020-02-28
2016	E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, A. Dalla Mora Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems published pages: 73101, ISSN: 0034-6748, DOI: 10.1063/1.4954968	Review of Scientific Instruments 87/7	2020-02-28

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