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ANaPSyS SIGNED

Artificial Natural Products System Synthesis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ANaPSyS project word cloud

Explore the words cloud of the ANaPSyS project. It provides you a very rough idea of what is the project "ANaPSyS" about.

regard relationships profoundly artificial anapsys logic privileged termed display conventional drastically classified pattern limited biogenetic overcome thereof restricted limiting consequence devises standard shared enhanced regardless natural architecturally structure chemical synthesis recognition intermediate congeners biosynthetic exclusively limitations categorizes diversification single family groups precursor hence anymore route leads owing structural retrosynthetic families group resembled creates devised synthetic network serves inspired pi confined basis exemplarily supersede strategic boosting upgraded macmillan accomplished core collective suggests revenue bio originate dogma efficiency origin replacing

Project "ANaPSyS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT KONSTANZ Organization address address: UNIVERSITATSSTRASSE 10 city: KONSTANZ postcode: 78464 website: www.uni-konstanz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.chemie.uni-konstanz.de/gaich/
Total cost	1˙497˙000 €
EC max contribution	1˙497˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT KONSTANZ UNIVERSITAT KONSTANZ Organization address address: UNIVERSITATSSTRASSE 10 city: KONSTANZ postcode: 78464 website: www.uni-konstanz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KONSTANZ)	coordinator	1˙497˙000.00

Map

Project objective

'Traditionally, natural products are classified into 'natural product families'. Within a family all congeners display specific structure elements, owing to their common biosynthetic pathway. This suggests a bio-inspired or 'collective synthesis', as has been devised by D: W. MacMillan. However, a biosynthetic pathway is confined to these structure elements, thus limiting synthesis with regard to structure diversification. In this research proposal the applicant exemplarily devises a strategic concept to overcome these limitations, by replacing the dogma of 'retrosynthetic analysis' with 'structure pattern recognition'. This concept is termed 'Artificial Natural Product Systems Synthesis — ANaPSyS', and aims to supersede the current 'logic of chemical synthesis' as a standard practice in this field. ANaPSyS exclusively categorizes natural products based on structural relationships — regardless of biogenetic origin. The structure pattern analysis groups natural products according to their shared core structure, and thereof creates a common precursor called 'privileged intermediate (PI)'. This intermediate is resembled in each of these natural products and is architecturally less complex. As a result every member of this natural product group can originate from a different natural product family and is obtained via this 'privileged intermediate', which serves as basis for the artificial synthetic network. With ANaPSyS a synthetic route is not restricted to a single target structure anymore (as in conventional synthesis). In comparison with bio-inspired synthesis, which is limited to a single natural product family, ANaPSyS enables the synthesis of a whole set of natural product families. With every synthesis accomplished, the network is upgraded — hence diversification leads to a rise in revenue. As a consequence, synthetic efficiency is drastically enhanced, therefore profoundly boosting and facilitating lead structure development. '

Publications

List of publications.
year	authors and title	journal	last update
2016	Sebastian KrÃ¼ger, Tanja Gaich Total Syntheses of Vellosimine, N -Methylvellosimine, and 10-Methoxyvellosimine and Formal Synthesis of 16-Epinormacusine B through a [5+2] Cycloaddition published pages: 4893-4899, ISSN: 1434-193X, DOI: 10.1002/ejoc.201600870	European Journal of Organic Chemistry 2016/28	2019-06-19
2019	Tanja Gaich, Christa Karoline Gisela Gerlinger Structure Pattern Based Total Synthesis published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201901308	Chemistry â€“ A European Journal	2019-08-05
2018	Tanja Gaich, Heiko Rebmann, Christa K. G. Gerlinger Gramâ€scale Total Syntheses of Sarpagine Alkaloids and nonâ€Natural Derivatives published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201805644	Chemistry â€“ A European Journal	2019-08-05
2018	Christa K. G. Gerlinger, Sebastian KrÃ¼ger, Tanja Gaich Total Synthesis of Parvineostemonine by Structure Pattern Recognition: A Unified Approach to Stemona and Sarpagine Alkaloids published pages: 3994-3997, ISSN: 0947-6539, DOI: 10.1002/chem.201800365	Chemistry - A European Journal 24/16	2019-05-09

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