ANaPSyS SIGNED

Project "ANaPSyS" data sheet

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 Partnership

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 Project objective

'Traditionally, natural products are classified into 'natural product families'. Within a family all congeners display specific structure elements, owing to their common biosynthetic pathway. This suggests a bio-inspired or 'collective synthesis', as has been devised by D: W. MacMillan. However, a biosynthetic pathway is confined to these structure elements, thus limiting synthesis with regard to structure diversification. In this research proposal the applicant exemplarily devises a strategic concept to overcome these limitations, by replacing the dogma of 'retrosynthetic analysis' with 'structure pattern recognition'. This concept is termed 'Artificial Natural Product Systems Synthesis — ANaPSyS', and aims to supersede the current 'logic of chemical synthesis' as a standard practice in this field. ANaPSyS exclusively categorizes natural products based on structural relationships — regardless of biogenetic origin. The structure pattern analysis groups natural products according to their shared core structure, and thereof creates a common precursor called 'privileged intermediate (PI)'. This intermediate is resembled in each of these natural products and is architecturally less complex. As a result every member of this natural product group can originate from a different natural product family and is obtained via this 'privileged intermediate', which serves as basis for the artificial synthetic network. With ANaPSyS a synthetic route is not restricted to a single target structure anymore (as in conventional synthesis). In comparison with bio-inspired synthesis, which is limited to a single natural product family, ANaPSyS enables the synthesis of a whole set of natural product families. With every synthesis accomplished, the network is upgraded — hence diversification leads to a rise in revenue. As a consequence, synthetic efficiency is drastically enhanced, therefore profoundly boosting and facilitating lead structure development. '

 Publications