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ENDYVE SIGNED

ENgineering DYnamic ViscoElasticity to study cell response

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ENDYVE project word cloud

Explore the words cloud of the ENDYVE project. It provides you a very rough idea of what is the project "ENDYVE" about.

differentiated viscoelastic characterised maturation dynamic screening initially biological time biochemical extracellular mechano albeit obtaining made scaffolding prior native drug preventing variant pluripotent disease progression ecm cues understating foetal vivo elastic crosslinking temporally enzyme cardiac provides regulation mediated finely stem enzymatic recapitulate static transduction cardiomyocyte societal biomechanical discrete substrate critical cells tissue biocompatible fibrosis implication substrates constant matrix mature human seeding effect stiff physical interactions engineering limiting date clinical vitro strategies endyve mechanical homeostasis generally aged tuneable viscoelasticity culture tumour infarcted levels first tissues exhibit neonatal ageing mimic cell pathophysiological

Project "ENDYVE" data sheet

The following table provides information about the project.

Coordinator	OPTICS11 BV Organization address address: DE BOELELAAN 1081 city: AMSTERDAM postcode: 1081 HV website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.researchgate.net/project/ENgineering-DYnamic-ViscoElasticity-to-study-cell-response-ENDYVE
Total cost	137˙999 €
EC max contribution	137˙999 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2018-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OPTICS11 BV OPTICS11 BV Organization address address: DE BOELELAAN 1081 city: AMSTERDAM postcode: 1081 HV website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	137˙999.00

Map

Project objective

In native tissues, the extracellular matrix (ECM) provides not only physical scaffolding to cells, but also biochemical and biomechanical cues affecting cell behaviour. ECM mechanical properties are critical in the regulation of cell behaviour during tissue development, homeostasis and disease via mechano-transduction. Albeit biological tissues generally exhibit a time variant (i.e. dynamic) viscoelastic behaviour that changes during development, ageing and disease, to date most of mechano-transduction studies have focused on static elastic properties only. The ENDYVE project aims at engineering tissue dynamic viscoelasticity typical of pathophysiological processes in-vivo to investigate its role on cell behaviour. Focusing on cardiomyocyte maturation, the viscoelastic properties of foetal, neonatal, aged and infarcted cardiac tissue will be characterised and used to design cell culture substrates with temporally tuneable mechanical properties that initially mimic foetal viscoelasticity and then can be made more stiff and less viscoelastic during cell culture via a second-step biocompatible enzymatic crosslinking to recapitulate dynamic changes of cardiac viscoelasticity in-vitro. First, stem cell cardiomyocyte behaviour will be investigated at discrete levels of constant viscoelasticity by seeding human induced pluripotent stem cells on substrates prior to and after enzyme-mediated crosslinking. Then the effect of dynamic changes in substrate viscoelasticity will be characterised during culture. Engineering dynamic viscoelasticity is a critical step towards a better understating of cell-ECM interactions and mechano-transduction, and could lead to the development of new strategies to finely control cell behaviour, with numerous potential societal and clinical implication, such as obtaining mature differentiated cells from stem cells for drug screening in vitro, or limiting, if not preventing, fibrosis and tumour progression.

Publications

List of publications.
year	authors and title	journal	last update
2018	G. Mattei, A. Ahluwalia A new analytical method for estimating lumped parameter constants of linear viscoelastic models from strain rate tests published pages: , ISSN: 1385-2000, DOI: 10.1007/s11043-018-9385-0	Mechanics of Time-Dependent Materials	2019-06-13
2017	Giorgio Mattei, Ludovica Cacopardo, Arti Ahluwalia Micro-Mechanical Viscoelastic Properties of Crosslinked Hydrogels Using the Nano-Epsilon Dot Method published pages: 889, ISSN: 1996-1944, DOI: 10.3390/ma10080889	Materials 10/8	2019-06-13

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