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ChondUb SIGNED

Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ChondUb project word cloud

Explore the words cloud of the ChondUb project. It provides you a very rough idea of what is the project "ChondUb" about.

demographic    plays    excellence    age    ligases    population    cure    dr    arthritis    group    collaborations    acquire    laboratory    molecular    groups    diseases    pathogenesis    cell    mouse    record    roles    previously    characterise    independent    ubiquitin    cellular    arising    learning    ubiquitination    track    envisage    protein    characterised    combination    excellent    cancer    eular    immune    biology    complementary    surgery    craniofacial    differentiation    disease    signaling    leader    osteoarthritis    creative    fellowship    shown    signalling    dynamics    relief    form    chief    oa    elucidated    weissman    degradation    treatment    skills    ligase    career    centre    newcastle    joint    stem    supervision    aligned    poorly    young    uncover    prof    health    chondrogenesis    pain    university    national    drugs    techniques    opportunity    achievement    10    models    conduct    substrates    multidisciplinary    regulates    horizon2020    reinforce    cartilage    wwp2    performed    replacement    gt    uk   

Project "ChondUb" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://research.ncl.ac.uk/chondub/
 Total cost 171˙792 €
 EC max contribution 171˙792 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 171˙792.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00

Map

 Project objective

Osteoarthritis (OA), characterised by cartilage degradation, is the most common form of arthritis affecting >10% of the EU population over 60 years of age. The pathogenesis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been elucidated. Ubiquitination regulates most signalling pathways and cellular processes. Previously, I have shown that ubiquitination plays a role in OA development. Here I aim to identify and characterise WWP2 substrates using a combination of novel techniques. In addition, I will investigate the role of WWP2 and its substrates in cartilage biology with the goal to uncover molecular targets for OA treatment and other WWP2-related diseases. The project is aligned with the “Health, Demographic Change and Well-Being” and “Understanding disease” challenges of Horizon2020. The work will be performed under supervision of Dr Weissman, Chief of the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute (US) and at “EULAR Centre of Excellence” at Newcastle University (UK) under supervision of Prof Young. Dr Weissman has an excellent track record in ubiquitin ligases biology and development of drugs targeting them and Prof Young in cartilage biology and mouse models of OA. Therefore, both groups are highly complementary for this project and envisage future collaborations arising from this fellowship. During this multidisciplinary project I will acquire new knowledge and will reinforce my research skills by learning novel techniques. It is a great opportunity to conduct a creative and independent research facilitating achievement of my main career goal to become an independent research group leader.

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The information about "CHONDUB" are provided by the European Opendata Portal: CORDIS opendata.

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