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EDGE SIGNED

Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EDGE project word cloud

Explore the words cloud of the EDGE project. It provides you a very rough idea of what is the project "EDGE" about.

discoveries serving methodological immunodeficiency scientists ideally virology overcoming people basic innovative biopharmaceutical market discovery severe caused unmet mechanisms acquired generation innovation laboratories acquire vaccines expertises demand translate prepare platform biotech immunocompromised oriented esr health companies progress gaps cultural network hospitals treatments spread trained infections diseases edge theoretical stage outstanding disease combined calls education interactive educate herpesvirus skills brings clinics hence molecular broad context carry satisfactory bench immunology esrs academia handling interactions prevention sectors individuals cutting treatment safe obtain insights life basis children herpesviruses bedside industry multiple elderly

Project "EDGE" data sheet

The following table provides information about the project.

Coordinator	AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://edge-itn.eu
Total cost	3˙961˙943 €
EC max contribution	3˙961˙943 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	coordinator	580˙163.00
2	AARHUS UNIVERSITETSHOSPITAL AARHUS UNIVERSITETSHOSPITAL Organization address address: PALLE JUUL-JENSENS BOULEVARD 99 city: AARHUS postcode: 8200 website: http://www.en.auh.dk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS)	participant	580˙163.00
3	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	516˙122.00
4	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	510˙748.00
5	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	participant	498˙432.00
6	MEDIZINISCHE HOCHSCHULE HANNOVER MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 website: www.mh-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	498˙432.00
7	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	273˙287.00
8	JANSSEN VACCINES & PREVENTION BV JANSSEN VACCINES & PREVENTION BV Organization address address: ARCHIMEDESWEG 4 city: LEIDEN postcode: 2333 CN website: www.crucell.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	255˙374.00
9	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	249˙216.00

Map

Project objective

Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunodeficiency, and with the increasing numbers of elderly in Europe, there is now an unmet demand for improved treatments of herpesvirus infections. Combined with the progress in basic herpesvirus research, this calls for education of a new generation of scientists with strong research skills, advanced insights into disease mechanisms, and understanding of how industry brings innovative research into the market. In this application we propose an interactive education program for early stage researchers (ESR) in leading European laboratories, hospitals, and biotech companies. The focus will be on the virology and immunology of herpesvirus infections in the context of basic research as well as application of research-acquired knowledge. Our program will prepare the ESRs to manage goal-oriented interactions between academia, the clinics, and the biotech industry. The ESRs will acquire broad theoretical and methodological expertises involving several sectors to obtain the skills required for overcoming the cultural gaps From Bench to Bedside and From Discovery to Innovation. This can only be achieved through a network-based approach. We propose to develop a platform to educate the next generation of scientists to solve the outstanding problems in prevention and treatment of herpesvirus infections. The ESRs will be ideally trained to translate cutting-edge discoveries to novel products and to innovative treatment serving the European people, and hence to improve handling of present and emerging health challenges, as well as to foster the European biopharmaceutical industry sector.

Deliverables

List of deliverables.
Recruitment ESRs	Documents, reports	2019-05-31 11:52:24
Characterization of SLE phenotypes in mice â€“ and impact on CMV infection	Documents, reports	2019-05-31 12:00:46
Draft Periodic Report	Documents, reports	2019-05-31 12:00:52
Recruitment Manager	Documents, reports	2019-05-31 12:00:47
Mid-term review meeting	Documents, reports	2019-05-31 12:00:46
Patent and publications in int. journals starting	Documents, reports	2019-05-31 12:00:48
Communication of subject to high school students	Documents, reports	2019-05-31 12:00:49

Take a look to the deliverables list in detail: detailed list of EDGE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201847483	European Journal of Immunology	2019-07-08
2018	P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins published pages: 55-64, ISSN: 0161-5890, DOI: 10.1016/j.molimm.2018.05.025	Molecular Immunology 101	2019-07-08
2018	Patrique Praest, A. Manuel Liaci, Friedrich FÃ¶rster, Emmanuel J.H.J. Wiertz New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins published pages: , ISSN: 0161-5890, DOI: 10.1016/j.molimm.2018.03.020	Molecular Immunology	2019-07-08
2017	Benson Ogunjimi, Shen-Ying Zhang, Katrine B. SÃ¸rensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections published pages: 3543-3556, ISSN: 0021-9738, DOI: 10.1172/JCI92280	Journal of Clinical Investigation 127/9	2019-07-08

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The information about "EDGE" are provided by the European Opendata Portal: CORDIS opendata.