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BAC-STAR SIGNED

Bacterial Adhesion Control through Surface TArgeted Regulation

Total Cost €

EC-Contrib. €

Partnership

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BAC-STAR project word cloud

Explore the words cloud of the BAC-STAR project. It provides you a very rough idea of what is the project "BAC-STAR" about.

spectrum microscopy pathogen surface variety adhesin electrodes facilitates blotting gingival assays functionalization immunofluorescence investigations feedback tested kinetics nutrient expressed stress loop mixed interdisciplinary charge generates fundamental elisas adhesion gradually vivo bacteria clones ultimate mimic tissue culture specialised whilst surfaces roughness pathogens cells microbial host hydrophobicity knockouts fuel exchange electrogens interaction preventing strains base cell mutagenesis porosity bacterial pure assay osteoblast improvement create monitored genes framework shear flow entire transferability library antifouling directed implants engineering wild time modifications knockout adhesins composition materials expressing oral fluorescence ing recombinant complement plate human coli western interactions

Project "BAC-STAR" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Total cost	208˙400 €
EC max contribution	208˙400 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-12-18

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	coordinator	208˙400.00

Map

Project objective

Fundamental investigations of bacterial adhesion will create the knowledge base to advance surface engineering approaches. Directed mutagenesis of adhesin genes in several oral pathogens will be used to create a library of knockout strains. Recombinant adhesins will also be over-expressed in E.coli. Assays will be developed to test the interaction of the resulting strains (wild-type, knockouts, over-expressing E.coli clones) with a range of materials, covering the entire spectrum of surface properties with defined roughness, hydrophobicity, porosity, charge and composition. Adhesion kinetics will be monitored in real time, using flow cells to mimic the shear stress and nutrient exchange on implants in vivo. This will complement plate-based fluorescence adhesion assays, western blotting, immunofluorescence microscopy, and ELISAs. Adhesion trends will be tested with targeted surface modifications in pure and mixed culture, creating a feedback-loop for assay improvement with gradually specialised surface functionalization. The ultimate goal is to develop surfaces that promote the adhesion of host tissue, such as human osteoblast cells or gingival cells, whilst still preventing pathogen adhesion. Understanding the fundamental interactions of bacteria with surfaces facilitates the transferability of the results from this project to a variety of further applications (e.g. adhesion of electrogens to microbial fuel cell electrodes; antifouling surfaces etc.). My proposal therefore has the potential to be high impact research, and generates the framework for future interdisciplinary projects.

Publications

List of publications.
year	authors and title	journal	last update
2019	Nandini Chauhan, Daniel Hatlem, Marcella Orwick-Rydmark, Kenneth Schneider, Matthias Floetenmeyer, Barth van Rossum, Jack C. Leo, Dirk Linke Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA) published pages: 844-862, ISSN: 0950-382X, DOI: 10.1111/mmi.14195	Molecular Microbiology 111/3	2020-02-13

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The information about "BAC-STAR" are provided by the European Opendata Portal: CORDIS opendata.