Explore the words cloud of the CELLFUSION project. It provides you a very rough idea of what is the project "CELLFUSION" about.
The following table provides information about the project.
Coordinator |
UNIVERSITE DE LAUSANNE
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Project website | https://wp.unil.ch/martinlab/research/the-mechanisms-of-cell-cell-fusion/ |
Total cost | 1˙999˙955 € |
EC max contribution | 1˙999˙955 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Take a look of project's partnership.
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1 | UNIVERSITE DE LAUSANNE | CH (LAUSANNE) | coordinator | 1˙999˙955.00 |
Cell fusion is critical for fertilization and development, for instance underlying muscle or bone formation. Cell fusion may also play important roles in regeneration and cancer. A conceptual understanding is emerging that cell fusion requires cell-cell communication, polarization of the cells towards each other, and assembly of a fusion machinery, in which an actin-based structure promotes membrane juxtaposition and fusogenic factors drive membrane fusion. However, in no single system have the molecular nature of all these parts been described, and thus the molecular basis of cell fusion remains poorly understood.
This proposal aims to depict the complete fusion process in a single organism, using the simple yeast model Schizosaccharomyces pombe, which has a long track record of discoveries in fundamental cellular processes. These haploid cells, which fuse to generate a diploid zygote, use highly conserved mechanisms of cell-cell communication (through pheromones and GPCR signaling), cell polarization (centred around the small GTPase Cdc42) and fusion. Indeed, we recently showed that these cells assemble an actin-based fusion structure, dubbed the actin fusion focus. Our five aims probe the molecular nature of, and the links between, signaling, polarization and the fusion machinery from initiation to termination of the process. These are:
1: To define the roles and feedback regulation of Cdc42 during cell fusion 2: To understand the molecular mechanisms of actin fusion focus formation 3: To identify the fusogen(s) promoting membrane fusion 4: To probe the GPCR signal for fusion initiation 5: To define the mechanism of fusion termination
By combining genetic, optogenetic, biochemical, live-imaging, synthetic and modeling approaches, this project will bring a molecular and conceptual understanding of cell fusion. This work will have far-ranging relevance for cell polarization, cytoskeletal organization, cell signalling and communication, and cell fate regulation.
year | authors and title | journal | last update |
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2019 |
Ingrid Billault-Chaumartin, Sophie G. Martin Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins published pages: 3165-3176.e6, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.07.088 |
Current Biology 29/19 | 2019-11-07 |
2018 |
Daniela Gallo Castro, Sophie G. Martin Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction published pages: 4215-4229, ISSN: 0021-9525, DOI: 10.1083/jcb.201806016 |
The Journal of Cell Biology 217/12 | 2019-08-05 |
2018 |
Aleksandar Vještica, Laura Merlini, Pedro Junior Nkosi, Sophie G. Martin Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization published pages: 397-400, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0407-5 |
Nature 560/7718 | 2019-08-05 |
2018 |
Bita Khalili, Laura Merlini, Vincent Vincenzetti, Sophie G. Martin, Dimitrios Vavylonis Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks published pages: e1006317, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006317 |
PLOS Computational Biology 14/7 | 2019-08-05 |
2017 |
Omaya Dudin, Laura Merlini, Felipe O. Bendezú, Raphaël Groux, Vincent Vincenzetti, Sophie G. Martin A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion published pages: e1006721, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006721 |
PLOS Genetics 13/4 | 2019-06-18 |
2018 |
Laura Merlini, Bita Khalili, Omaya Dudin, Laetitia Michon, Vincent Vincenzetti, Sophie G. Martin Inhibition of Ras activity coordinates cell fusion with cell–cell contact during yeast mating published pages: 1467-1483, ISSN: 0021-9525, DOI: 10.1083/jcb.201708195 |
The Journal of Cell Biology 217/4 | 2019-06-18 |
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