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Antibodyomics SIGNED

Vaccine profiling and immunodiagnostic discovery by high-throughput antibody repertoire analysis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Antibodyomics project word cloud

Explore the words cloud of the Antibodyomics project. It provides you a very rough idea of what is the project "Antibodyomics" about.

context largely throughput quantitatively medicine standardized repertoire experimental sequences repertoires quantitative profiling lays phenotype summary revolution titers patterns first public tracing correction ngs progress vital big complete expand antibodies antibody advantage diversity discover fundamentally somatic lacking rational hypermutation immunodiagnostics clonal model bias foundation vaccine link time biological question group molecular subunit vaccination serum landscapes bioinformatic answer health data error accurate vaccines genotype generation sequencing wealth fundamental preliminary provides pipeline lineage discovery mouse

Project "Antibodyomics" data sheet

The following table provides information about the project.

Coordinator	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	1˙492˙586 €
EC max contribution	1˙492˙586 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-06-01 to 2021-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	coordinator	1˙492˙586.00

Map

Project objective

Vaccines and immunodiagnostics have been vital for public health and medicine, however a quantitative molecular understanding of vaccine-induced antibody responses is lacking. Antibody research is currently going through a big-data driven revolution, largely due to progress in next-generation sequencing (NGS) and bioinformatic analysis of antibody repertoires. A main advantage of high-throughput antibody repertoire analysis is that it provides a wealth of quantitative information not possible with other classical methods of antibody analysis (i.e., serum titers); this information includes: clonal distribution and diversity, somatic hypermutation patterns, and lineage tracing. In preliminary work my group has established standardized methods for antibody repertoire NGS, including an experimental-bioinformatic pipeline for error and bias correction that enables highly accurate repertoire sequencing and analysis. The overall goal of this proposal will be to apply high-throughput antibody repertoire analysis for quantitative vaccine profiling and discovery of next-generation immunodiagnostics. Using mouse subunit vaccination as our model system, we will answer for the first time, a fundamental biological question within the context of antibody responses - what is the link between genotype (antibody repertoire) and phenotype (serum antibodies)? We will expand upon this approach for improved rational vaccine design by quantitatively determining the impact of a comprehensive set of subunit vaccination parameters on complete antibody landscapes. Finally, we will develop advanced bioinformatic methods to discover immunodiagnostics based on antibody repertoire sequences. In summary, this proposal lays the foundation for fundamentally new approaches in the quantitative analysis of antibody responses, which long-term will promote the development of next-generation vaccines and immunodiagnostics.

Publications

List of publications.
year	authors and title	journal	last update
2018	Enkelejda Miho, Alexander Yermanos, CÃ©dric R. Weber, Christoph T. Berger, Sai T. Reddy, Victor Greiff Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00224	Frontiers in Immunology 9	2019-04-20
2017	Victor Greiff, CÃ©dric R. Weber, Johannes Palme, Ulrich Bodenhofer, Enkelejda Miho, Ulrike Menzel, Sai T. Reddy Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires published pages: 2985-2997, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1700594	The Journal of Immunology 199/8	2019-04-20
2018	Alexander Dimitri Yermanos, Andreas Kevin Dounas, Tanja Stadler, Annette Oxenius, Sai T. Reddy Tracing Antibody Repertoire Evolution by Systems Phylogeny published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02149	Frontiers in Immunology 9	2019-04-20
2018	Derek M Mason, CÃ©dric R Weber, Cristina Parola, Simon M Meng, Victor Greiff, William J Kelton, Sai T Reddy High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis published pages: 7436-7449, ISSN: 0305-1048, DOI: 10.1093/nar/gky550	Nucleic Acids Research 46/14	2019-04-20
2018	Cristina Parola, Daniel Neumeier, Sai T. Reddy Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering published pages: 31-41, ISSN: 0019-2805, DOI: 10.1111/imm.12838	Immunology 153/1	2019-04-20

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The information about "ANTIBODYOMICS" are provided by the European Opendata Portal: CORDIS opendata.