Explore the words cloud of the TRANSREGULON project. It provides you a very rough idea of what is the project "TRANSREGULON" about.
The following table provides information about the project.
Coordinator |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Organization address contact info |
Coordinator Country | Germany [DE] |
Total cost | 2˙496˙250 € |
EC max contribution | 2˙496˙250 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-AdG |
Funding Scheme | ERC-ADG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-07-01 to 2021-06-30 |
Take a look of project's partnership.
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1 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (Munich) | coordinator | 2˙496˙250.00 |
The regulation of gene transcription by RNA polymerase (Pol) II underlies cell differentiation and organism development, and its dysregulation causes many cancers. Transcription regulation occurs during initiation, when Pol II assembles with initiation factors on promoter DNA, but also during mRNA chain elongation, when Pol II pauses near the promoter before it restarts upon activation. Our previous ERC Advanced Grant ‘TRANSIT’ enabled us to provide molecular insights into yeast Pol II initiation and its regulation by the Mediator coactivator complex (Plaschka et al., Nature 2015; Sainsbury et al., Nature 2012, Lariviere et al, Nature 2012). Here, with our new proposal ‘TRANSREGULON’ we wish to open a new frontier and provide the structural basis for mammalian Pol II regulation during elongation. We will use an integrated structural biology approach combining X-ray crystallography, cryo-electron microscopy, and crosslinking, to obtain the first atomic structure of a mammalian Pol II enzyme (aim 1), the structure of the negative elongation factor NELF (aim 2), which is required for promoter-proximal pausing by mammalian Pol II, and the threedimensional architecture of the promoter-proximally paused Pol II complex (aim 3) containing the multiprotein pausing factors NELF and DSIF, and eventually also the pause release factor p-TEFb. This ground-breaking work will make the transition from yeast to human structural biology of transcription, will provide the molecular basis for a central mechanism of cellular regulation, and will advance structural biology methods for dissecting large and transient mammalian multicomponent complexes.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Gert-Jan Hendriks, Lisa A. Jung, Anton J. M. Larsson, Michael Lidschreiber, Oscar Andersson Forsman, Katja Lidschreiber, Patrick Cramer, Rickard Sandberg NASC-seq monitors RNA synthesis in single cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11028-9 |
Nature Communications 10/1 | 2019-08-29 |
2019 |
Salma Sohrabi-Jahromi, Katharina B Hofmann, Andrea Boltendahl, Christian Roth, Saskia Gressel, Carlo Baejen, Johannes Soeding, Patrick Cramer Transcriptome maps of general eukaryotic RNA degradation factors published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47040 |
eLife 8 | 2019-08-29 |
2017 |
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25637 |
eLife 6 | 2019-06-13 |
2017 |
Youwei Xu, Carrie Bernecky, Chung-Tien Lee, Kerstin C. Maier, Björn Schwalb, Dimitry Tegunov, Jürgen M. Plitzko, Henning Urlaub, Patrick Cramer Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex published pages: 15741, ISSN: 2041-1723, DOI: 10.1038/ncomms15741 |
Nature Communications 8 | 2019-06-13 |
2017 |
Saskia Gressel, Björn Schwalb, Tim Michael Decker, Weihua Qin, Heinrich Leonhardt, Dirk Eick, Patrick Cramer CDK9-dependent RNA polymerase II pausing controls transcription initiation published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.29736 |
eLife 6 | 2019-06-13 |
2017 |
Margaux Michel, Carina Demel, Benedikt Zacher, Björn Schwalb, Stefan Krebs, Helmut Blum, Julien Gagneur, Patrick Cramer TTâ€seq captures enhancer landscapes immediately after Tâ€cell stimulation published pages: 920, ISSN: 1744-4292, DOI: 10.15252/msb.20167507 |
Molecular Systems Biology 13/3 | 2019-06-13 |
2017 |
Benedikt Zacher, Margaux Michel, Björn Schwalb, Patrick Cramer, Achim Tresch, Julien Gagneur Accurate Promoter and Enhancer Identification in 127 ENCODE and Roadmap Epigenomics Cell Types and Tissues by GenoSTAN published pages: e0169249, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0169249 |
PLOS ONE 12/1 | 2019-06-13 |
2017 |
Stefano Malvezzi, Lucas Farnung, Claudia M. N. Aloisi, Todor Angelov, Patrick Cramer, Shana J. Sturla Mechanism of RNA polymerase II stalling by DNA alkylation published pages: 12172-12177, ISSN: 0027-8424, DOI: 10.1073/pnas.1706592114 |
Proceedings of the National Academy of Sciences 114/46 | 2019-06-13 |
2017 |
Ameet Shetty, Scott P. Kallgren, Carina Demel, Kerstin C. Maier, Dan Spatt, Burak H. Alver, Patrick Cramer, Peter J. Park, Fred Winston Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation published pages: 77-88.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.02.023 |
Molecular Cell 66/1 | 2019-03-18 |
2017 |
Hauke S. Hillen, Andrey V. Parshin, Karen Agaronyan, Yaroslav I. Morozov, James J. Graber, Aleksandar Chernev, Kathrin Schwinghammer, Henning Urlaub, Michael Anikin, Patrick Cramer, Dmitry Temiakov Mechanism of Transcription Anti-termination in Human Mitochondria published pages: 1082-1093.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.09.035 |
Cell 171/5 | 2019-03-18 |
2017 |
Lucas Farnung, Seychelle M. Vos, Christoph Wigge, Patrick Cramer Nucleosome–Chd1 structure and implications for chromatin remodelling published pages: 539-542, ISSN: 0028-0836, DOI: 10.1038/nature24046 |
Nature 550/7677 | 2019-03-18 |
2017 |
Patrick Cramer Structural Molecular Biology—A Personal Reflection on the Occasion of John Kendrew\'s 100th Birthday published pages: 2603-2610, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2017.05.007 |
Journal of Molecular Biology 429/17 | 2019-03-18 |
2017 |
S. Schilbach, M. Hantsche, D. Tegunov, C. Dienemann, C. Wigge, H. Urlaub, P. Cramer Structures of transcription pre-initiation complex with TFIIH and Mediator published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24282 |
Nature | 2019-03-18 |
2018 |
Seychelle M. Vos, Lucas Farnung, Henning Urlaub, Patrick Cramer Structure of paused transcription complex Pol II–DSIF–NELF published pages: 601-606, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0442-2 |
Nature 560/7720 | 2019-03-18 |
2017 |
R. Kohler, R. A. Mooney, D. J. Mills, R. Landick, P. Cramer Architecture of a transcribing-translating expressome published pages: 194-197, ISSN: 0036-8075, DOI: 10.1126/science.aal3059 |
Science 356/6334 | 2019-03-18 |
2017 |
Christoph Engel, Tobias Gubbey, Simon Neyer, Sarah Sainsbury, Christiane Oberthuer, Carlo Baejen, Carrie Bernecky, Patrick Cramer Structural Basis of RNA Polymerase I Transcription Initiation published pages: 120-131.e22, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.03.003 |
Cell 169/1 | 2019-03-18 |
2017 |
Carlo Baejen, Jessica Andreani, Phillipp Torkler, Sofia Battaglia, Bjoern Schwalb, Michael Lidschreiber, Kerstin C. Maier, Andrea Boltendahl, Petra Rus, Stephanie Esslinger, Johannes Söding, Patrick Cramer Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes published pages: 38-49.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.02.009 |
Molecular Cell 66/1 | 2019-03-18 |
2018 |
Lucas Farnung, Seychelle M. Vos, Patrick Cramer Structure of transcribing RNA polymerase II-nucleosome complex published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07870-y |
Nature Communications 9/1 | 2019-03-18 |
2017 |
Hauke S. Hillen, Yaroslav I. Morozov, Azadeh Sarfallah, Dmitry Temiakov, Patrick Cramer Structural Basis of Mitochondrial Transcription Initiation published pages: 1072-1081.e10, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.10.036 |
Cell 171/5 | 2019-03-18 |
2017 |
Merle Hantsche, Patrick Cramer Conserved RNA polymerase II initiation complex structure published pages: 17-22, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2017.03.013 |
Current Opinion in Structural Biology 47 | 2019-03-18 |
2019 |
Jan Jakub Żylicz, Aurélie Bousard, Kristina Žumer, Francois Dossin, Eusra Mohammad, Simão Teixeira da Rocha, Björn Schwalb, Laurène Syx, Florent Dingli, Damarys Loew, Patrick Cramer, Edith Heard The Implication of Early Chromatin Changes in X Chromosome Inactivation published pages: 182-197.e23, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.11.041 |
Cell 176/1-2 | 2019-03-18 |
2018 |
Michael Lidschreiber, Ashley D Easter, Sofia Battaglia, Juan B RodrÃguez-Molina, Ana Casañal, Manuel Carminati, Carlo Baejen, Pawel Grzechnik, Kerstin C Maier, Patrick Cramer, Lori A Passmore The APT complex is involved in non-coding RNA transcription and is distinct from CPF published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky845 |
Nucleic Acids Research | 2019-03-18 |
2018 |
Seychelle M. Vos, Lucas Farnung, Marc Boehning, Christoph Wigge, Andreas Linden, Henning Urlaub, Patrick Cramer Structure of activated transcription complex Pol II–DSIF–PAF–SPT6 published pages: 607-612, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0440-4 |
Nature 560/7720 | 2019-09-05 |
2019 |
Goran Kokic, Aleksandar Chernev, Dimitry Tegunov, Christian Dienemann, Henning Urlaub, Patrick Cramer Structural basis of TFIIH activation for nucleotide excision repair published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10745-5 |
Nature Communications 10/1 | 2019-08-29 |
2019 |
Leonhard Wachutka, Livia Caizzi, Julien Gagneur, Patrick Cramer Global donor and acceptor splicing site kinetics in human cells published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.45056 |
eLife 8 | 2019-08-29 |
2017 |
Carrie Bernecky, Jürgen M Plitzko, Patrick Cramer Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp published pages: 809-815, ISSN: 1545-9993, DOI: 10.1038/nsmb.3465 |
Nature Structural & Molecular Biology 24/10 | 2019-09-05 |
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The information about "TRANSREGULON" are provided by the European Opendata Portal: CORDIS opendata.
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